Navigation Links
The assembly of protein strands into fibrils
Date:4/11/2010

The Atomic Force Microscope depicts on its screen the few nanometer thick and few micrometer long fibers as white flexible sticks, crisscrossing the surface on which they are deposited. The very peculiar property of these proteins lies in fact that they can self assemble into complex ribbon-like twisted fibers.

Researchers at ETH Zrich, EPF Lausanne and University of Fribourg have teamed up to take Atomic Force Microscopy images of the fibers and to analyze them using concepts from polymer physics and theoretical modeling. This combination of expertise has lead them to propose a set of general rules governing the assembly of filaments into thicker and twisted ribbon like fibers. Their results are published in the current issue of the scientific journal "Nature Nanotechnology". "The model that we propose is extremely precise in its predictions", says Raffaele Mezzenga, Professor of Food and Soft Materials Sciences at the ETH Zrich. "Up to now there was no such exact and general model for the formation of Amyloid fibers", continues Giovanni Dietler, Professor of Physics of Living Matter, at the EPF Lausanne.

The structure of the Amyloid fibers as it was unveiled by the experiments, surprised the researchers. Single proteins build the long filaments and subsequently the filaments assemble side by side to form the ribbon-like twisted fibers.

Mezzenga explains that the ribbon-like structure is the logic consequence of the strong charge carried by the building blocks of the fibers. In fact, the single proteins feel a strong mutual repulsion preventing them to pack and the ribbon structure is the only one that permits to limit this repulsion. Presently one missing information in the present model, is the exact nature of the short range attraction between the building blocks that drives in the first place the assembly among the protein filaments. Scientists agree that along the filaments there are charge-less domains of hydrophobic characte
'/>"/>

Contact: Giovanni Dietler
giovanni.dietler@epfl.ch
41-216-930-446
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Advocates Rally Southland Assembly Health Committee Members to Pass AB 1694
2. Flexible Assembly Systems Announces New Torque Calculator App for the iPhone
3. Wednesday, Dec. 2: News From the 95th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago
4. Leukemia-related protein 16 and colorectal carcinoma
5. Caltech scientists uncover structure of key protein in common HIV subgroup
6. UD team develops new method for producing proteins critical to medical research
7. Proteins in unroasted coffee beans may become next-generation insecticides
8. Protein in Breast Tumors May Predict Chemo Response
9. Tumors Use a Protein to Hide From Immune System
10. Newly identified proteins critical to FA pathway DNA repair function
11. Proteins may point to alcohol use test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... ... University of Pittsburgh Cancer Institute (UPCI) scientists recently led a panel ... tests that better incorporate personalized medicine into diagnosing the condition. , Their clinical ... in the July issue of the scientific journal Thyroid . The American ...
(Date:7/6/2015)... York, NY (PRWEB) , ... July 06, 2015 ... ... their health care from nurses or midwives, yet there is a large gap ... nursing and midwifery research required to improve health outcomes and reduce unnecessary or ...
(Date:7/6/2015)... ... July 06, 2015 , ... doTERRA, the leading global essential oils company, ... Most recently, Jowers held the position as Director of the Hinckley Institute at the ... decade building the institute, Jowers states that he was ready for a new challenge, ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... & Associates has once again teamed up with Family Emergency Shelter Coalition (FESCO) ... move toward self-sufficiency. FESCO was created especially to provide emergency services and support ...
(Date:7/6/2015)... Los Angeles, CA (PRWEB) , ... July 06, 2015 , ... ... now offering patients the opportunity to achieve their ideal appearance through comprehensive treatment solutions. ... discuss their goals with the doctor and receive a plan that resolves each of ...
Breaking Medicine News(10 mins):Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 2Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 3Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 4Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 5Health News:Columbia Nursing Nairobi Summit: Setting a Clinical Research Agenda for Africa 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 3Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 4Health News:Carlson & Associates Insurance Agency and Nonprofit Family Emergency Shelter Coalition (FESCO) Initiate New Charity Campaign in Alameda County, CA to Provide for Homeless 2Health News:Carlson & Associates Insurance Agency and Nonprofit Family Emergency Shelter Coalition (FESCO) Initiate New Charity Campaign in Alameda County, CA to Provide for Homeless 3Health News:Los Angeles Plastic Surgeon, Dr. Paul Nassif, is Now Offering Comprehensive Facial Plastic Surgery Procedures 2
... Have Improved Benefits for Prevention, Mental,Health and ... INDIANAPOLIS, June 12 Today a minority ... protect and improve,Medicare for the 44 million ... for Patients and Providers Act, which would ...
... Have Improved Benefits for Prevention, Mental,Health and Low-Income ... 12 Today a minority of the,U.S. Senate ... the 44 million Americans who depend on it. ... would have improved Medicare,s,prevention, mental health, and low-income ...
... the lung condition by 25%, Chinese study says ... people suffering from chronic obstructive pulmonary disease (COPD), ... of symptoms, Chinese researchers report. , COPD ... usually brought on by smoking, for which there,s ...
... DAYTON, Ohio, June 12 Robbins & Myers, Inc.,(NYSE: ... its third quarter fiscal,2008 financial results for the period ... June 30, 2008. A live webcast of the conference ... with Peter C. Wallace, President,and Chief Executive Officer, and ...
... be Listed on the NASDAQ Capital Market, OAKLAND, ... Heart Corporation (the "Company") announced today that the,Company has ... Stock Exchange. The Company,s business moved primarily to the,United ... trades occur on,the NASDAQ Capital Market. The common shares ...
... voted 54,to 39 in favor of S. 3101, ... 2008. However, that did not achieve the 60 ... that provide,prompt payment of Medicare Part D prescription ... cuts for generic prescription,drugs. In response Bruce T. ...
Cached Medicine News:Health News:AARP Indiana Key Vote News Alert: AARP Dismayed by Senate Vote to Block Medicare Improvement Bill 2Health News:AARP Indiana Key Vote News Alert: AARP Dismayed by Senate Vote to Block Medicare Improvement Bill 3Health News:AARP Disappointed by U.S. Senate Vote to Block Medicare Improvement Bill 2Health News:AARP Disappointed by U.S. Senate Vote to Block Medicare Improvement Bill 3Health News:Anti-Mucus Drug Slows Symptoms of COPD 2Health News:Anti-Mucus Drug Slows Symptoms of COPD 3Health News:WorldHeart Announces Voluntary Delisting from the Toronto Stock Exchange 2
(Date:7/6/2015)... July 6, 2015 Mauna ... the multidisciplinary confocal laser endomicroscopy platform, announced today ... Ministry of Health, Labor and Welfare ... solution, the AQ-Flex 19 miniprobe.   ... 19 miniprobe is comprised of a fiber-optic microscope ...
(Date:7/6/2015)... , July 6, 2015  Protiviti, a global consulting ... Internal Auditing around the World publication ( www.protiviti.com/iaworld ... and reported on the evolution of the internal audit ... the globe as a means to providing senior executives ... this strategic business function. The 2015 edition ...
(Date:7/6/2015)... June 29, 2015 Research ... the "Pharmaceutical Grade Sodium Chloride Market by Applications, ... report to their offering. The pharmaceutical ... CAGR of 6.9% between 2014 and 2019 in terms ... 690 KT by 2019. The report on ...
Breaking Medicine Technology:Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3New Edition of Internal Auditing Around the World from Protiviti Explores Changes and Trends 2Global Pharmaceutical Grade Sodium Chloride Market Report 2015 2Global Pharmaceutical Grade Sodium Chloride Market Report 2015 3
... BEVERLY HILLS, Calif., June 27, 2011 OXIS International, ... Paris: OXI) today announced that it has named former ...  The Company,s Board now has four members, including three ... bring an executive of Ken,s caliber to the OXIS ...
... 27, 2011 Columbia Laboratories, Inc. (Nasdaq: CBRX ... today announced that the U.S. Food and Drug Administration (FDA) ... PROCHIEVE ® (progesterone gel) for the reduction of risk ... in the mid-trimester of pregnancy. The acceptance of the NDA ...
Cached Medicine Technology:OXIS International Names Former Wal-Mart Executive Ken Eaton to Board of Directors 2OXIS International Names Former Wal-Mart Executive Ken Eaton to Board of Directors 3Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 2Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 3Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 4
... to quality patient care., ,S/5 Anesthesia ... to anesthesia delivery. As part of the ... features, electronically controlled gas delivery and agent ... to create a truly integrated system. The ...
... Tegagel hydrogel wound filler and ... are amorphous hydrogel dressings specially formulated ... that has been shown to enhance ... formula meets clinical needs for management ...
... SS is a complete physician preference card ... management system for all the supply management ... preference card system combined with a broad ... entire case cart and operating suite supply ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
Medicine Products: