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The University of California at San Francisco Medical Center Pioneers System-wide Adoption of Masimo Rainbow SET Technology

One of the nation's top five hospitals, UCSF converts to Masimo SET pulse

oximetry and leverages revolutionary new noninvasive measurement


IRVINE, Calif., Feb. 13 /PRNewswire-FirstCall/ -- Masimo, the inventor of Pulse CO-Oximetry and Measure-Through-Motion & Low Perfusion Pulse Oximetry, today announced the completion of UCSF Medical Center's system-wide implementation of Masimo SET pulse oximetry and the Masimo Rainbow SET technology platform-establishing UCSF Medical Center as the first hospital to implement Masimo Rainbow SET capabilities system-wide.

Initially, UCSF Medical Center performed an extensive pulse oximetry comparison and thorough evaluation spanning virtually every department and found that Masimo SET's obtained accurate and reliable oxygen saturation measurements under difficult conditions, including patient motion and low perfusion, as the chief reason for conversion to Masimo SET. Also, as part of the evaluation, UCSF clinicians utilized new Masimo Rainbow SET technology to noninvasively and continuously measure physiologic and hemodynamic components that were previously only available by invasive tests. As a result, UCSF decided to expand the adoption of Masimo technologies beyond pulse oximetry to include the noninvasive patient monitoring capabilities of the Masimo Rainbow SET technology platform.

UCSF Medical Center, a 600-bed hospital and academic medical center, is among the top five hospitals in the nation according to U.S. News and World Report. UCSF Medical Center, which also includes the 180-bed UCSF Children's Hospital, Mount Zion for outpatient care and specialized programs, and more than 60 outreach clinics, is also home to the only nationally-designated Comprehensive Cancer Center and the only nationally designated Center of Excellence in Women's Health in Northern California.

"Previously, low perfusion and patient motion were two of our toughest challenges and the biggest obstacles to obtaining the accurate and reliable SpO2 measurements we rely on to guide our treatment decisions," said Patricia Roth, MD, Medical Director of Anesthesia Operating Room Support Services, Associate Professor of Anesthesia & Perioperative Care, UCSF Medical Center, San Francisco, California. "Masimo SET provides continuous, accurate oxygen saturation measurements that reflect a patient's true status -- even during low perfusion and motion. In addition, Masimo adhesive sensors have proven to be more robust, allowing us to use just one sensor from Pre-Op, OR (Operating Room) and PACU (Post-Anesthesia Care Unit) through to the general care floor or ICU (Intensive Care Unit), while Masimo SET Perfusion Index (PI) and Pleth Variability Index (PVI) measurements have exciting potential clinical applications and added value."

In addition to their system-wide standardization on Masimo SET pulse oximetry, UCSF also wanted to ensure that every site within their system was Rainbow-enabled -- allowing UCSF clinicians to utilize advanced Masimo Rainbow SET technology and revolutionary new noninvasive measurement capabilities throughout their network facilities. Masimo Rainbow SET is an upgradable noninvasive blood constituent monitoring platform capable of measuring blood constituents that previously required invasive procedures. Masimo Rainbow SET's first application is Pulse CO-Oximetry, the first and only technology platform capable of continuously and noninvasively measuring Carboxyhemoglobin (SpCO(TM)) and Methemoglobin (SpMet(TM)), in addition to Oxyhemoglobin (SpO2), Perfusion Index (PI), Pleth Variability Index (PVI(TM)) and pulse rate.

By quickly and accurately determining levels of SpCO and SpMet -- two critical dyshemoglobins proven to increase morbidity and mortality in a broad range of clinical settings -- clinicians can accurately determine their patients' true oxygenation status. PVI provides a continuous and noninvasive quantified measurement of changes in the perfusion index that may compromise cardiac function and affect systemic circulation, with potential clinical applications for noninvasive hypovolemia detection and fluid responsiveness monitoring. These new noninvasive measurement capabilities, unique to the Masimo Rainbow SET technology platform, allow for more precise and timely diagnosis and treatment.

Joe E. Kiani, CEO and Chairman of Masimo, stated; "UCSF Medical Center is recognized throughout the world for offering pioneering treatments. From becoming the first in the world to successfully perform surgery on a baby still in the womb to developing life-saving treatments for premature infants whose lungs aren't fully developed, UCSF is now pioneering the application of new noninvasive measurements enabled by the Masimo Rainbow SET technology platform to help advance the care they deliver now and into the future. This combination of innovative medicine, advanced technology and compassionate care is what makes UCSF a world leader in healthcare. We are proud of our pioneering partnership with UCSF."

About Masimo

Masimo (Nasdaq: MASI) develops innovative monitoring technologies that significantly improve patient care -- helping solve "unsolvable" problems. In 1995, the company debuted Measure-Through Motion and Low Perfusion pulse oximetry, known as Masimo SET, and with it virtually eliminated false alarms and increased pulse oximetry's ability to detect life-threatening events. More than 100 independent and objective studies demonstrate that Masimo SET provides the most trustworthy SpO2 and pulse rate measurements even under the most difficult clinical conditions, including patient motion and low peripheral perfusion. In 2005, Masimo introduced Masimo Rainbow SET, a breakthrough noninvasive blood constituent monitoring platform that can measure many blood constituents that previously required invasive procedures. Rainbow SET continuously and noninvasively measures Carboxyhemoglobin (SpCO(TM)) and Methemoglobin (SpMet(TM)), Pleth Variability Index (PVI(TM)), in addition to Oxyhemoglobin (SpO2), Perfusion Index (PI) and pulse rate, allowing early detection and treatment of potentially life-threatening conditions. Founded in 1989, Masimo has the mission of "Improving Patient Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications." Additional information about Masimo and its products may be found at

Forward Looking Statements

This press release may include forward-looking statements. These forward-looking statements are based on current expectations about future events affecting us and are subject to uncertainties and factors, all of which are difficult to predict and many of which are beyond our control, including: risks related to our assumption that UCSF Medical Center's standardization to Masimo technologies will serve to provide substantially increased revenues for the company and risks related to our assumption that Masimo SET and Masimo Rainbow SET will deliver a sufficient level of clinical improvement over alternative pulse oximetry and patient monitoring systems to allow for rapid adoption of the technology, as well as other factors discussed in the "Risk Factors" section of our quarterly report on Form 10-Q for the quarter ended September 29, 2007, filed with the Securities and Exchange Commission on November 1, 2007. Although we believe that the expectations reflected in our forward-looking statements are reasonable, we do not know whether our expectations will prove correct. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. We do not undertake any obligation to update, amend or clarify these forward- looking statements or the risk factors contained in our quarterly report on Form 10-Q for the quarter ended September 29, 2007, whether as a result of new information, future events or otherwise, except as may be required under the federal securities laws.

Masimo, SET, Signal Extraction Technology, Improving Outcomes and Reducing Cost of Care by Taking Noninvasive Monitoring to New Sites and Applications, Rainbow, SpCO, SpMet, PVI and Pulse CO-Oximeter are trademarks or registered trademarks of Masimo Corporation.

SOURCE Masimo Corporation
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