Navigation Links
The TET1 enzyme steers us through fetal development and fights cancer
Date:4/13/2011

To ensure normal fetal development and prevent disease, it is crucial that certain genes are on or off in the right time intervals. Researchers in Professor Kristian Helin's group at BRIC, University of Copenhagen, have now shown how the TET1 enzyme controls the activity of our genes. The results are just published in the journal Nature.

Control of our genes

The complete human genetic code was mapped in 2000. However, it has become clear that the genetic code itself only in part can answer how an individual develops and is protected against disease. What is detrimental is also how our genes are controlled what genes are on or off at certain times. This is in part regulated by specific cellular enzymes that can attach small chemical groups, methyl groups, to our DNA:

-The methyl groups can turn off the gene that lies in a stretch of DNA where it is added. TET1 is another type of enzyme that can fine tune the signals that control gene activity by changing the methyl groups which thereafter are removed, says Kristian Helin.

TET1 controls fetal development

Kristine Williams, Jesper Christensen and Marianne Terndrup Pedersen are the 3 key persons in the Helin laboratory at BRIC contributing with the new results:

-Our most important finding is that TET1 acts like a safe guard and prevents that methyl groups are attached to genes that needs to be active for normal growth and development of our cells. That is crucial for normal fetal development, says PhD student Kristine Williams. Selected genes needs to be active in the stem cells of our body, before the cells are specialized to one of the more than 200 specialized cell types that exist in our body. Other genes need only to be active in specialized cell types as for example liver cells, muscle cells or nerve cells.

When cancer cells develop

The results also contribute to the understanding of what goes wrong when some cel
'/>"/>

Contact: Kristian Helin
kristian.helin@bric.ku.dk
453-532-5668
University of Copenhagen
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Investigators discover enzyme essential for healthy lung development
2. Newly discovered role for enzyme in neurodegenerative diseases
3. Enzyme helps prepare lung tissue for metastatic development
4. Heart Enzymes May Predict Outcome After Bypass Surgery
5. Breathing easy: LSU biochemists offer first 3-D model of asthma-causing inflammation enzyme
6. Princess Margaret Hospital researchers identify a key enzyme that affects radiation response
7. Chaperone enzyme provides new target for cancer treatments
8. Virus might fight brain tumors better if armed with bacterial enzyme, study shows
9. Enzyme inhibition or removal may prevent or treat ischemic retinopathy
10. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
11. UH physicists study behavior of enzyme linked to Alzheimers, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The TET1 enzyme steers us through fetal development and fights cancer
(Date:12/25/2014)... (PRWEB) December 25, 2014 The short film ... was created in honor of a true 9/11 hero, Welles ... film festivals including the 24 hours of Nuremberg International Short ... Bangladesh. , Actress, screenwriter and director Luciana Lagana ... this film together with her husband, Gregory Graham ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
(Date:12/25/2014)... When head lice hits a home or school, parents ... rid of it while keeping it from taking over the ... the solution right in their neighborhood: Lice Troopers . ... full spectrum head lice screening and treatment services to families ... Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... with complex chronic illnesses can receive effective, less expensive care ... easy access to a team of dedicated health care professionals, ... become seriously ill and need either hospitalization or a trip ... enhanced medical home clinic at the University of Texas in ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- Overeating is common during the ... in moderation, an expert says. "Don,t arrive at a ... if you know you,ll be attending a party, but deprivation ... lead dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., ... eat healthy during the day and even to have a ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3
... ... partnership agreement with Agog Creative Group to become the exclusive distribution ... spoken-word audio products. The Relaxation Company products include the clinically proven ... over one million copies. The Relaxation Company products will be distributed ...
... may one day allow pilots to peer through fog and ... surgery. Developed by Princeton engineers, the method relies on ... light that would typically make the image unrecognizable, such as ... In their experiments, the researchers restored an obscured image into ...
... The secret to job satisfaction is an overall sense of ... If you,re unhappy in life, you,re unlikely to find satisfaction ... studies conducted between 1967 and 2008. , All of the ... which is also known as subjective well-being. , "We used ...
... ... for Autism” for Easter Seals , ... IL (Vocus) April 2, 2010 -- Ever feel compelled to help a cause you believe in, ... the fight for families with autism so they can get the care, guidance and support they ...
... ... Bill’s new book reveals the insider secrets of the new work selection ... best work positions much easier, much faster and more completely than ever ... business conditions that best match business owners so both employees and owners ...
... ... students with an in-depth yoga teacher training and career resource guide to provide insight ... , ... (PRWEB) April 2, 2010 -- Natural Healers, the Internet’s premier resource for alternative medicine ...
Cached Medicine News:Health News:Sounds True Announces Licensing Partnership with The Relaxation Company, Becomes Market-Leader in Benefit-Oriented Sound Healing Music 2Health News:Sounds True Announces Licensing Partnership with The Relaxation Company, Becomes Market-Leader in Benefit-Oriented Sound Healing Music 3Health News:Engineers turn noise into vision 2Health News:Engineers turn noise into vision 3Health News:Those Who Enjoy Life More Likely to Be Happy at Work 2Health News:Autism May Not Affect Every Family, But Every Family Can Affect Autism 2Health News:Autism May Not Affect Every Family, But Every Family Can Affect Autism 3Health News:Autism May Not Affect Every Family, But Every Family Can Affect Autism 4Health News:Go to Play Every Day & Call it Work: Finally-The Book to Get the Best Jobs For Everyone 2Health News:Yoga Teacher Training Guide Launches on Natural Healers 2Health News:Yoga Teacher Training Guide Launches on Natural Healers 3Health News:Yoga Teacher Training Guide Launches on Natural Healers 4
(Date:12/24/2014)... BARBARA, Calif. , Dec. 23, 2014 In ... Junior Doctors, Association of Sierra Leone , ... Sierra Leone for the treatment of local health ... While a new dedicated Ebola care center was constructed ... virus, the facility is not available for local Sierra Leonean ...
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ... corporate offices in Aliso Viejo , ... due to the tremendous growth and worldwide expansion, a ... of patented SnoreRx, the anti snore cure have exceeded ... said, "We are now in 23 countries and ...
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a ... of epilepsy, today announced it will participate in the 33 ... 14, 2015, in San Francisco . ... Officer, will speak at 11:00 AM Pacific Time.  A live ... on the Investor Relations link on the Cyberonics home page ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2
... 20, 2012 Reportlinker.com announces that ... available in its catalogue: ... Europe Market Size, Segment And Country ... http://www.reportlinker.com/p0797078/Nutraceuticals-Product-Market-Western-Europe-Market-Size-Segment-And-Country-Analysis-And-Forecasts-2007-2017.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Nutraceutical   ...
... 2012 CooperVision, a leading global contact lens manufacturer, ... Awards with a "Best of" award for excellence ... with the company on its new brand strategy and ... highest worldwide recognition of its kind. CooperVision,s ...
Cached Medicine Technology:Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 2Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 3Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 4CooperVision Wins 2012 REBRAND 100® Global Award 2
... critical patients more waveforms, 12-Lead ECG, ... package and cardiac output bundled into ... with your patients., We use quick-action ... which means less time spent looking,through ...
... Nylon Finger Traps for optimum patient comfort. ... patients skin with a firm grip. ISI Nylon ... traction system when used with the ISI Digi ... Nylon Finger Traps are available in non-sterile packs ...
... The ApexPro FH ... spread spectrum wireless infrastructure ... WMTS for dependable communication ... FH offers scalability of ...
Spacelabs offers an approach that allows your telemetry and step-down units to configure systems to meet their telemetry requirements. Our modular telemetry system data are integrated into the depart...
Medicine Products: