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The Surgeons of Los Angeles Colon and Rectal Surgical Associates are Now Offering Exparel for Use in Local Anesthesia During Anorectal Operations


Los Angeles Colon and Rectal Surgical Associates is pleased to be able to offer the latest development in anesthesia and postoperative pain control to its patients in Los Angeles – Exparel®, a new type of drug delivery system for colorectal patients.

The use of an intra-operative local anesthetic, in the form of microsomal bupivicaine, will be of great benefit to large numbers of patients undergoing most forms of anorectal surgery. The operative site can be extremely uncomfortable after the procedures have been completed. The need for strong opioid pain medications is common, and these medications will often require that a regular dose be taken several times a day. The use of microsomal bupivicaine reduces this reliance on other pain medications, and makes the period of time immediately after surgery considerably more comfortable for the patient. Dr. Gary Hoffman, a senior physician at Los Angeles Colon and Rectal Surgeons, has stated, “Anorectal procedures in particular, can be quite painful during this recovery period, and microsomal bupivicaine promises to be an important adjunct in pain control and relief.”

Clinical Use During Anorectal Operations

“We have been very happy with our results to date,” said Dr. Gary Hoffman in Los Angeles. “Our results are bolstered by well-designed studies and trials supporting the use of this anesthetic delivery system. The system is effective and patient response has been positive. Our preliminary results echo the strong results seen in several institutions. Microsomal bupivicaine works because the delivery system is composed of microvesicles, or small bubbles if you will, which contain the anesthetic bupivicaine, which is delivered to the precise location where it is needed. It then diffuses slowly into the tissues, over 72 hours, and provides extended post-operative relief.”

About Exparel®, A New Type of Delivery System

Exparel® is a local anesthetic and delivery system injected into the affected area at the beginning of a medical operation. The anesthetic drug bupivicaine is used in conjunction with the delivery system known as DepoFoam®, and has been clinically proven to be safe and effective. The bupivicaine is surrounded by DepoFoam® in the form of microvesicles, and the use of Exparel® in this manner has been shown to reduce the need for opioid pain medications post-operatively. The anesthetic may be effective for up to 72 hours after injection.

The difference between microsomal bupvicaine and other types of local anesthetic injections is the manner in which it is delivered. While injections are used for the majority of local anesthestic drugs, the vesicles that contain the medication provide a slow release that leads to prolonged pain relief. Exparel® has been shown to be most effective when injected directly into the site of the operation, and often leads to an increase in the length of time before opioid pain relief is needed. Studies have shown the median time before opioids are used with normal local anesthesia is 1.2 hours. With Exparel®, this time increases to almost 15 hours, thus reducing the risks associated with opioid use. Additionally, administering Exparel® has reduced the amount of supplemental oral pain medication.

About Los Angeles Colon and Rectal Surgical Associates
Los Angeles Colon and Rectal Surgical Associates was formed in 1957, and provides patients with focused diagnostic, compassionate medical and surgical treatment. The doctors specialize in the diagnosis and treatment of various diseases that affect the colon, rectum, and anus, such as colon cancer, hemorrhoids, and colon polyps.

Los Angeles Colon and Rectal Surgical Associates hosts a website,, which provides comprehensive information to help patients find helpful information. It has many pages that serve as a guide for people looking to learn more about the care offered by LACRSA. Additional information about the physicians is also found on the website. For convenience, there are downloadable forms available on the website for patients looking to schedule an appointment. LACRSA serves Los Angeles, Beverly Hills, Santa Monica, West Hollywood, Culver City, and all other parts of Southern California. The doctors also treat patients from many areas of the United States as well as international patients.

For more information or to see whether microsomal bupivicaine (Exparel®) would be suitable for you, contact Los Angeles Colon and Rectal Surgical Associates for an evaluation.

Los Angeles Colon and Rectal Surgical Associates
9400 Brighton Way, Suite 307
Beverly Hills, CA 90210
+1 (310) 273-2310

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