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The Results From a Clinical Trial Led by the Montreal Heart Institute Demonstrate That Drug Reduces Inflammation in Patients With Serious Cardiovascular Disease
Date:11/10/2008

nt inhibition of Leukotriene B4 (LTB4) production at 12 weeks. The secondary endpoint of change from baseline in urine Leukotriene E4 (LTE4) also showed significant inhibition at all dose levels.

A statistically significant reduction from baseline as compared to placebo was observed in high-sensitivity C-reactive protein (hs-CRP) levels in the highest dose group of patients treated for 24 weeks. Significant reductions in hs-CRP levels were not observed in the ACS trial in patients treated for 12 weeks, perhaps due in part to variability in the level of hs-CRP at the baseline as a result of recent heart attack or unstable angina.

About Atherosclerosis and Inflammation

Atherosclerosis is the result of chronic inflammation and the build-up of plaque in arterial blood vessel walls. Plaque consists of inflammatory cells, cholesterol and cellular debris. Atherosclerosis, depending on its severity and the location of the artery it affects, may result in blockage in certain

vessels and can cause a rupture of inflamed plaque tissue, leading to MACE such as heart attack and stroke, which are leading causes of death worldwide.

About VIA-2291

VIA-2291 is designed to complement current standard of care therapies that treat cardiac risk factors, such as statins, antiplatelet and blood pressure medications. VIA-2291 is initially targeted to address the secondary prevention market for patients who have already suffered a major adverse cardiac event, but eventually could be beneficial to the broader 15.8 million patients in the U.S. who have coronary artery disease. VIA-2291 has been tested in more that 1,300 patients in clinical trials.

About the Montreal Heart Institute

Founded in 1954 by Dr. Paul David, the Montreal Heart Institute constantly aims for the highest standards of excellence in the cardiovascular field through its leadership in prevention, ultra-specialized care, training of professionals, clinical and fundamenta
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SOURCE Montreal Heart Institute
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