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The RNA drug revolution -- a new approach to gene therapy
Date:1/23/2008

ael McManus, PhD, from the University of California, San Francisco, which presents the current understanding of microRNA mechanisms of action and the potential for applying this knowledge to the development of RNAi-based treatments.

In the review by Anton McCaffrey, PhD, and Rebecca Marquez, MA, entitled, Advances in Micro-RNAs: Implications for Gene Therapists, the authors discuss the likelihood that microRNAs, which are believed to regulate as many as one-third of all human gene transcripts (or messenger RNAs), are implicated in many human diseases. Using gene therapy to manipulate microRNA levels represents an attractive new approach for controlling gene expression and identifying targeted and effective therapeutics.

"The concept of using RNA as a therapeutic product is quite attractive and adds an important new dimension to the field of nucleic acid based therapeutics including gene therapy. Mark Kay, Associate Editor of Human Gene Therapy, has organized an exciting series of reviews summarizing the state of the art of this emerging field," says James M. Wilson, MD, PhD, Editor-in-Chief, and Head of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, in Philadelphia.


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Contact: Vicki Cohn
vcohn@liebertpub.com
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

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