Navigation Links
The RNA drug revolution -- a new approach to gene therapy
Date:1/23/2008

New Rochelle, NY, January 23, 2008RNA interference (RNAi) represents an innovative new strategy for using small RNA molecules to silence specific genes associated with disease processes, and a series of review articles describing the state-of-the-art and potential therapeutic applications of RNAi and microRNAs will begin with two review papers in the January 2008 issue (Volume 19, Number 1) of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. The papers are available free online.

At least six clinical trials using RNA interference (RNAi) have been approved, with many more coming down the pipeline, according to the Editorial by Mark A. Kay, MD, PhD, an Associate Editor of Human Gene Therapy and the Dennis Farrey Family Professor in Pediatrics and Professor of Genetics at Stanford University School of Medicine. One thing is clear, adds Kay, small RNAs as a therapeutic platform are here to stay.

The excitement surrounding RNAi and the two main approaches to delivering RNA-based therapeuticsas mature siRNA molecules or as short hairpin RNAs (shRNAs)relates to the discovery of native microRNA molecules in human cells and their intrinsic ability to block the expression of a target gene. siRNA therapeutic strategies in development aim to harness the cells natural RNAi pathway and specifically silence a mutant or dysregulated gene.

Traditionally, gene therapy has focused on supplying a normal copy of a faulty gene, whereas RNAi turns off a problematic gene. These contrasting approaches share some of the same techniques and challenges, including delivery of a therapeutic gene or siRNA into cells.

Human Gene Therapy will publish a series of review papers in four consecutive issues focusing on a range of topics related to therapeutic applications of small RNAs. The series begins in the January issue with a paper entitled, Behind the Scenes of a Small RNA Gene-Silencing Pathway, by Gregory Ku, MD, PhD, and Mich
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Local Oncology Group Leads Online Effort to Revolutionize Cancer Care
2. Join the Vitamin D Revolution: How to Get 30 Minutes of Daily Sunshine for Optimal Health
3. VIDEO from Medialink and Revolution Health: RevolutionHealth.com Launches Resolutions 2.0
4. UCLA Program Aims to Revolutionize Kidney Transplants
5. Prescription for an electronic revolution?
6. Informed Medical Communications Sells Consumer Internet Division to Revolution Health
7. Chinas Anti-Aging Revolution
8. New Low-Impact Cosmetic Surgery Treatments Revolutionizing Industry
9. ILC Dover Launches Revolutionary ArmorFlex (R) Pharmaceutical Product Contact Film
10. The Homeopathic Revolution
11. Six Olympic Legends Battling Chronic Diseases Lead Revolution in Advancing Pharmacy Care as Medco Launches the Tour of Champions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Dennis Thompson HealthDay Reporter ... news about the experimental Ebola vaccine that U.S. officials are ... shows a precursor of that vaccine produced a safe and ... the vaccine, when given to more than 100 Ugandans in ... blood cells that could potentially protect a person against infection ...
(Date:12/24/2014)... -- Longer and colder body cooling does not reduce the ... a lack of oxygen, a new study finds. The ... -- called hypoxic ischemic encephalopathy -- can be reduced by ... for 72 hours, experts say. Research has shown that ... this study examined if the same would be true in ...
(Date:12/24/2014)... News) -- Though most patients with obsessive-compulsive disorder (OCD) ... 10 percent to 20 percent have a form of ... say. However, patients with this so-called "refractory OCD" ... of brain surgery that disables certain brain networks believed ... between patients most likely to benefit from the surgery, ...
(Date:12/24/2014)... TUESDAY, Dec. 23, 2014 (HealthDay News) -- If you ... off if you are not treated by a cardiologist, ... actually improved when cardiologists left town for annual professional ... with cardiac arrest who were admitted to a teaching ... days, but 70 percent died when these meetings were ...
(Date:12/22/2014)... December 22, 2014 As part ... senior care service in San Diego and ... of its senior care team with ongoing online ... Golden Care is provided by Caregiverlist®. Caregiverlist® ... caregivers with the most reliable eldercare options, highest ...
Breaking Medicine News(10 mins):Health News:Early Study Offers Hope for an Ebola Vaccine 2Health News:Early Study Offers Hope for an Ebola Vaccine 3Health News:Early Study Offers Hope for an Ebola Vaccine 4Health News:Greater Cooling of Oxygen-Deprived Infants Fails to Improve Survival 2Health News:Scans May Spot People Who'll Benefit From Surgery for OCD 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 3Health News:Golden Care Partners with Nationally Recognized Caregiver Training Service 2
... The Madras Institute of Trauma (MIOT) deserves to be called ... minimally invasive surgery (MIS) for all kinds of surgeries. // ... that provides 40 fold magnification of a specific body ... liver, cardiac bypass, surgical excision of brain tumor, spinal injury ...
... cell research in the state with the approval of 61% ... have impeded the initiative. // ,The officials now ... will be initiated. Zach Hall, president of the California Institute ... would commence the project as soon as possible. ...
... head of Psycho and Geriatrics Ward at the Punjab Institute of ... their relatives after they have been declared mentally fit by doctors. ... such patients who have completely recovered but no place to go. ... members they say that these patients are of no use and ...
... rushing off at lunch breaks, coughing up ?4,500 for Jiffy ... for such breast implant operations//, and is getting into the ... Kirkham was one of the first to be on their ... by her mom and a student loan. She said: ...
... buster, pain reliever, sleep-inducer, hair conditioner and wrinkle remover, ... guessing! Intimate sex with your partner can provide the much ... NHS helpline says "Forget about jogging round the block or ... fact, good bout of 'sexercise'." ,The NHS site ...
... has spent the last two decades in chains in a ... Pradesh//. His family said that Mansharam did not move at ... ,His brother Bhogchand says that Mansharam was chained to a ... "We spent a lot of money to get him treated ...
Cached Medicine News:Health News:Any Form Of Minimally Invasive Surgery- Name It & They Do It! 2Health News:Momentum of Stem cell research impeded by legal challenges 2Health News:Is mental illness a social stigma? 2
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... decision support to healthcare providers for behavioral health ... has secured $30 million in equity financing from ... C. Drosos , President and Chief Executive Officer. ... adoption and development of Assurex Health,s GeneSight ...
(Date:12/24/2014)... RALEIGH, N.C. , Dec. 23, 2014  Endo ... ENDP ) (TSX: ENL), and BioDelivery Sciences ... that they have submitted a New Drug Application (NDA) ... and Drug Administration (FDA).  Buprenorphine HCl Buccal Film is ... to require daily, around-the-clock, long-term opioid treatment and for ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... 4, 2011 Novo Nordisk announced today the ... application (app) to assist in the diagnosis of ... Kessler, MD, Professor of Medicine and Pathology and ... Lombardi Comprehensive Cancer Center. Coags Uncomplicated features a ...
... 4, 2011 /PRNewswire-Asia-FirstCall/ – Lotus Pharmaceuticals, Inc. (OTC Bulletin ... a fast-growing, profitable developer, manufacturer and seller of medicine ... today announced that it will add two additional stories ... which is currently under construction and is scheduled to ...
Cached Medicine Technology:Novo Nordisk Creates First Mobile Application to Help Doctors Diagnose Bleeding Disorders 2Lotus Pharmaceuticals to Expand Construction of Beijing Facility 2Lotus Pharmaceuticals to Expand Construction of Beijing Facility 3
... pacemaker family, which includes the world's ... the most advanced pacemaker technology available, ... the first and only U.S. commercially ... fibrillation (AF). The AF Suppression algorithm ...
... the real-time monitoring surveillance of a ... tools. Moreover, the Information Center is ... so that monitoring data can be ... radiology images, archived data, lab results, ...
... system uses catheters that are controlled ... console. The console processes the refrigerant, ... tip of the catheter, creates cryogenic ... an easy-to-use touch-screen interface. From this ...
... tasks and delivers consistently reliable ... and ensure testing accuracy in ... automated reticulocyte counts and three-dimensional ... sensitivity, specificity and efficiency in ...
Medicine Products: