Market Will be Driven by Increasing Use of Established Agents That Include Avastin, Erbitux, Rituxan/MabThera, According to a New Report from Decision
WALTHAM, Mass., June 10 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that the monoclonal antibodies (MAbs) drug market will more than double to $16.7 billion in 2016, driven by the increasing use of currently available therapies that include Roche/Genentech/Chugai's Avastin, Bristol-Myers Squibb/ImClone/Merck KGaA's Erbitux, Genentech/Biogen Idec/Chugai's Rituxan / Roche's MabThera.
The new Pharmacor report entitled Antibody Therapies in Oncology finds that the major driving force behind market growth of the MAbs drug class through 2016 will be the label expansion of currently approved MAbs into other patient populations as well as approvals in new indications in the United States, France, Germany, Italy, Spain, United Kingdom and Japan. In 2006, Avastin held approvals in non-small-cell lung cancer and colorectal cancer -- since that time, of the cancers covered in the report, it has gained approval for breast cancer and renal cell carcinoma and is expected to be approved for prostate cancer and ovarian cancer. Avastin's applicability across multiple tumor types, even if it sees only limited patient share in some indications, is key to its success.
While not as successful as Avastin in terms of revenue generation or its use across as many tumor types, Erbitux generates significant sales in colorectal cancer and squamous cell carcinoma of the head and neck. Also, Erbitux is expected to be approved for the treatment of non-small-cell lung cancer, which will dramatically boost its sales. Lastly, although the use of Rituxan/MabThera in non-Hodgkin's lymphoma has reached saturation in many of the subtypes of the disease, this agent is forecasted to gain approval for chronic lymphocytic leukemia, allowing for increased prescribing in Europe where the cost-constrained environment limits off-label use.
Market sales will also be driven by the introduction of four new MAbs by 2016: Genmab/GlaxoSmithKline's ofatumumab for non-Hodgkin's lymphoma and chronic lymphocytic leukemia, Medarex/Bristol-Myers Squibb's ipilimumab for malignant myeloma, Genmab's zanolimumab for T-cell lymphoma, and Genentech/Roche/Chugai's pertuzumab for breast cancer.
"These emerging MAbs will contribute significant sales by 2016," said Clair Gricks, Ph.D., analyst at Decision Resources, "They will provide new therapeutic options for patients with currently limited choices or will improve the efficacy of established agents when used in combination. The majority of market growth, however, will be driven by label expansions and increased uptake of currently marketed MAbs."
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