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The Lancet: New oral drug regimens cure hardest-to-treat hepatitis C
Date:7/27/2014

90% of previously untreated patients and 82% who were intolerant of, or who had been treated unsuccessfully using standard regimens, were cured. No differences in response were seen in individuals who had characteristics such as being male, older, African American race, or having advanced liver diseasethat are recognised as predictors of poor response to treatment.

According to Professor Manns, "The efficacy and safety of 24 weeks of daclatasvir plus asunaprevir represents a huge improvement on the first generation of protease inhibitor based triple therapies for HCV genotype 1b infection (up to 48 weeks of boceprevir or telaprevir in combination with PEG/RBV). This new all-oral interferon and ribavirin-free combination could provide a more effective, safer, shorter, and simpler treatment option for those traditionally hard-to-cure patients with cirrhosis or those who have failed to respond to existing therapies."[3]

In the COSMOS study, a team of US and European researchers led by Professor Eric Lawitz from the Texas Liver Institute, University of Texas Health Science Center in San Antonio, USA, randomly assigned 167 individuals with HCV genotype 1a and 1b to receive a 12-week or 24-week course of once-daily sofosbuvir plus simeprevir with or without ribavirin. After just 12 weeks of treatment without ribavirin, 93% of participants (including those with cirrhosis and previous non-responders to interferon-based treatment) were curedwith no detectable virus in their blood 3 months after treatment had stopped. Neither extending treatment to 24 weeks or adding ribavirin provided any clear benefit. The 12-week sofosbuvir plus simeprevir regimen was well tolerated with less than 2% of participants reporting serious adverse events or discontinuing treatment due to an adverse event.

According to Professor Lawitz, "We saw a cure rate of about 93% with only 12 weeks of treatment using an all-oral regimen that did not include interferon or ribaviri
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Contact: Professor Michael P Manns
manns.michael@mh-hannover.de
49-511-532-3305
The Lancet
Source:Eurekalert

Page: 1 2 3

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