Navigation Links
The Lancet: 1 in 3000 blood donors in England infected with hepatitis E

The first systematic analysis of hepatitis E virus (HEV) transmission by blood components indicates that about 1 in 3000 donors in England have HEV in their plasma. The findings, published in The Lancet, suggest that around 1200 HEV-containing blood components (eg, red cells, platelets, and fresh frozen plasma) are likely to be transfused every year in England.

The study retrospectively screened 225 000 individual blood donations collected in south east England between Oct, 2012 and Sept, 2013 for HEV RNA. 79 donors were found to be currently infected with genotype 3 HEV (that can spread directly from animals to humans)a prevalence of about 1 in 2848. The 79 donations had been used to prepare 129 blood components, 62 of which had been transfused. Follow-up of 43 exposed recipients showed transmission had occurred in 18 (42%) patients.

"HEV genotype 3 infections are widespread in the English population, including blood donors. We estimate that between 80 000 and 100 000 human HEV infections are likely to have occurred in England during the year of our study", principal investigator Professor Richard Tedder from the Blood Borne Virus Unit at Public Health England, explained.

"Although rarely causing any acute illness, hepatitis E infections may become persistent in immunosuppressed patients, putting them at risk of future chronic liver disease, and a policy is needed to identify these persistently infected patients and provide them with appropriate antiviral treatment. However, our study indicates that the overall burden of harm resulting from transfusion-transmitted HEV is slight. Although on a clinical basis alone there appears no pressing need at this time for blood donations to be screened, a broader discussion over harm mitigation is now required."*

Writing in a linked Comment, Professor Jean-Michel Pawlotsky from Hpital Henri Mondor, Universit Paris-Est, Crteil, France, calls for the systematic screening of blood components for hepatitis E infection to be introduced in areas where HEV is endemic, such as the European Union.

He writes, "Despite[the] high prevalence, the high rate of transmission by infected blood or blood products, the non-negligible morbidity and mortality related to HEV infection (especially in patient populations exposed to blood or blood product transfusion), and the lack of efficient antiviral therapy, Hewitt and colleagues surprisingly conclude that "there seems no pressing need to move rapidly with the introduction of donation screening"The potential clinical results of blood-borne HEV infection should not be downplayed; in particular, the risk of serious complications and death exists. Thus, on the basis of Hewitt and colleagues' and other studies, I believe that systematic screening of blood components for markers of hepatitis E infection should be implemented in areas where HEV is endemic (eg, the European Union), based on HEV RNA detection. No doubt this position will be debated and, whatever the experts think, a political decision will have to be made. I suspect that pooled HEV RNA testing will become obligatory in blood banks soon."

Contact: Professor Richard Tedder
The Lancet

Related medicine news :

1. The Lancet: China halves tuberculosis prevalence in just 20 years
2. The Lancet: UK has one of the highest death rates for children in western Europe
3. The Lancet: Midwifery matters more than ever
4. The Lancet: New trial suggests cheaper drugs for common heart attack procedure could improve outcomes and save health budgets millions
5. The Lancet: Sierra Leone researchers call for improved health surveillance and communication around Ebola crisis
6. Infection Might Raise Blood Clot Risk for Older Adults: Study
7. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
8. Common Blood Pressure Drug Safe for Heart Failure: Study
9. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
10. High Blood Pressure May Be Especially Lethal for Blacks
11. Changes in gene expression may help explain high blood pressure in pregnancy
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation ... research and serving the lymphoma community through a comprehensive series of education programs, ... Hope; A Commitment to Cure last night at the Mandarin Oriental in New ...
(Date:10/13/2015)... — , ... ... Association of America (MOAA) will hold its 2015 annual meeting ... a free military career fair; informational seminars; a luncheon featuring ... the Joint Chiefs of Staff; and the Community Heroes Award ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Vision Group ... Vision of San Diego, California. With brands including The LASIK Vision Institute and TLC ... making it the nationwide leader in laser vision correction. , Global Laser Vision will ...
(Date:10/13/2015)... ... October 13, 2015 , ... PhyMed Healthcare Group , ... its partnership with WPC Healthcare , a provider of predictive analytics solutions ... data into an aggregated data repository necessary to perform reporting and analytics on ...
(Date:10/13/2015)... Texas (PRWEB) , ... October 13, 2015 , ... Symposium ... for the 19th annual Dallas Cosmetic Symposium to be held March 2nd and 3rd, ... place immediately afterwards, draws plastic surgeons and cosmetic physicians from around the world. , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... YORK , Oct. 13, 2015 Pomerantz ... filed against Amicus Therapeutics, Inc. ("Amicus" or the "Company")(NASDAQ: ... filed in United States District Court, District of ... a class consisting of all persons or entities who ... 1, 2015 inclusive (the "Class Period"). This class action seeks ...
(Date:10/13/2015)... , Oct. 13, 2015  Vitamin Angels – ... and mothers in need of nutritional support - announced ... by the United Nations (UN). The UN,s newly established ... – are a recent follow up to the Millennium ... deadline for completion. The new 17 Global Goals intend ...
(Date:10/13/2015)... , Oct. 13, 2015   Generational Equity ... middle-market businesses, is pleased to announce the acquisition of ... in Largo, Florida , by Meridian ... on September 11, 2015. Florida ... --> Florida . To learn ...
Breaking Medicine Technology: