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The Lancet: 1 in 3000 blood donors in England infected with hepatitis E
Date:7/27/2014

The first systematic analysis of hepatitis E virus (HEV) transmission by blood components indicates that about 1 in 3000 donors in England have HEV in their plasma. The findings, published in The Lancet, suggest that around 1200 HEV-containing blood components (eg, red cells, platelets, and fresh frozen plasma) are likely to be transfused every year in England.

The study retrospectively screened 225 000 individual blood donations collected in south east England between Oct, 2012 and Sept, 2013 for HEV RNA. 79 donors were found to be currently infected with genotype 3 HEV (that can spread directly from animals to humans)a prevalence of about 1 in 2848. The 79 donations had been used to prepare 129 blood components, 62 of which had been transfused. Follow-up of 43 exposed recipients showed transmission had occurred in 18 (42%) patients.

"HEV genotype 3 infections are widespread in the English population, including blood donors. We estimate that between 80 000 and 100 000 human HEV infections are likely to have occurred in England during the year of our study", principal investigator Professor Richard Tedder from the Blood Borne Virus Unit at Public Health England, explained.

"Although rarely causing any acute illness, hepatitis E infections may become persistent in immunosuppressed patients, putting them at risk of future chronic liver disease, and a policy is needed to identify these persistently infected patients and provide them with appropriate antiviral treatment. However, our study indicates that the overall burden of harm resulting from transfusion-transmitted HEV is slight. Although on a clinical basis alone there appears no pressing need at this time for blood donations to be screened, a broader discussion over harm mitigation is now required."*

Writing in a linked Comment, Professor Jean-Michel Pawlotsky from Hpital Henri Mondor, Universit Paris-Est, Crteil, France, calls for the systematic screening of blood c
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Contact: Professor Richard Tedder
richard.tedder@phe.gov.uk
44-020-832-76014
The Lancet
Source:Eurekalert

Page: 1 2

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