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The Interplay of Kinase Broad Profiling and Phenotypic Screening Discussed in DiscoverX Webinar
Date:11/9/2016

Kinases play important roles in many biological signaling pathways, as an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. Kinase inhibitors are, therefore, potentially found as actives in typical phenotypic screens.

DiscoverX is sponsoring a free webinar on the interplay of kinase broad profiling and phenotypic screening, which will provide details on the design of the Janssen kinase inhibitor broad profiling project and its impact on general early kinase drug discovery projects.

The team at Janssen Research & Development will be sharing two examples during this webinar, the mouse embryonic stem cell stemness assay, run in collaboration with Dundee DSTT, and the literature reported splicing corrector assay of pre-Lamin A. They will share results of how kinase inhibitor broad profiling and chem-bioinformatic analyses developed in the IMI OpenPhacts consortium can impact target deconvolution after phenotypic screening. The outcomes of these analyses are lists of potential kinase targets for further biological validation.

DiscoverX has arranged for Dr. Edgar Jacoby, senior principal scientist in computational chemistry at Janssen Research & Development, to be the presenter during this webinar.

Jacoby received his doctorate in computational chemistry from RWTH Aachen University, before doing post-doctoral work in molecular biophysics at Harvard Medical School and the University of Chicago. In 2013, he joined Janssen Research & Development as a senior principal scientist in computational chemistry. Prior to joining Janssen Research & Development, Jacoby worked at Servier doing research framework in molecular modeling. He has also worked at the Combinatorial Chemistry Group at Novartis Central Technologies as lab head for the in-silico design of combinatorial compound libraries, as well as led the Molecular and Library Informatics Group in the Novartis Center of Proteomic Chemistry in Basel from 2002 to 2012.

LabRoots will host the webinar December 7, 2016, beginning at 9:00 a.m. PT, 12:00 p.m. ET. To learn more about this event, or to register for free, click here.

About DiscoverX
DiscoverX Corporation, headquartered in Fremont, CA, USA, is a leader in the design, manufacture and sale of biochemical and cell-based assays for the drug discovery & life science markets. This industry-leading portfolio of products and services, under the KINOMEscan®, PathHunter® and BioMAP® brands, are used to aid life science research and enable rapid development of safe and effective biologic and small molecule drugs, by improving research productivity, effectiveness of screening, lead optimization & bioanalytical campaigns, as well as providing predictive tools that deliver physiologically relevant insights on drug molecules from early discovery through pre-clinical development. DiscoverX embodies an innovative approach to creating life science tools that have been widely adopted across the globe in pharmaceutical, biotechnology and academic laboratories.

About LabRoots
LabRoots is the leading scientific social networking website and producer of educational virtual events and webinars. Contributing to the advancement of science through content sharing capabilities, LabRoots is a powerful advocate in amplifying global networks and communities. Founded in 2008, LabRoots emphasizes digital innovation in scientific collaboration and learning, and is a primary source for current scientific news, webinars, virtual conferences, and more. LabRoots has grown into the world’s largest series of virtual events within the Life Sciences and Clinical Diagnostics community.

Read the full story at http://www.prweb.com/releases/2016/11/prweb13819545.htm.


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