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The International Meeting for Autism Research (IMFAR)
Date:5/14/2014

ore likely to show signs of autism by age 2 than children with little or no repetitive behavior. Though some degree of repetitive behavior is expected in healthy early development, significantly elevated repetitive behavior at 12 months age may be a 'red flag' for autism. It is notable that we found differences using a simple, 5-10 minute parent report. This suggests that parents are able to detect these behaviors early on, making restricted and repetitive behavior a good potential target for early screening and intervention programs.

The use of high density EEG to investigate circuit miswiring in infants at risk for autism -- C. A. Nelson; A. R. Levin; M. F. Shi and H. Tager-Flusberg, Boston Children's Hospital; Harvard; Boston University.

Autism spectrum disorder (ASD) is a complex, highly heritable disorder that involves primary impairments in language and communication. The disorder is heterogeneous and long-term outcomes vary considerably. In large scale studies of infants with an older sibling with the disorder, it has been estimated that approximately 1:5 such infants will eventually be diagnosed with an ASD. Despite this elevated risk, distinguishing which infants will go on to develop an ASD from those who will not remain challenging.

In our longitudinal study of "infant sibs," we operate from the premise that autism reflects altered neural connectivity. Examining neural circuitry in living children is challenging. In our work we have made use of the recording of the electroencephalogram (EEG) as a way to infer the development of neural circuitry. We report that at different ages, using different analytic routines and different elements of the EEG, we are able to consistently distinguish high risk from low risk infants and in some cases, distinguish infants who subsequently develop an ASD from those who do not. For example, we have reported that gamma activity from 6 to18 months distinguishes high from low risk infants,
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Contact: Adam Pockriss
apockriss@rubenstein.com
212-843-8286
Rubenstein Associates, Inc.
Source:Eurekalert

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