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The International Meeting for Autism Research (IMFAR)
Date:5/14/2014

We approached this aim by employing a placebo-controlled, double-blind, crossover design with three months of treatment with IGF-1 and three months of placebo in random order, separated by a four week wash-out period. Results provide evidence that IGF-1 is safe, well tolerated, and associated with significant improvement in social impairment as measured by the Aberrant Behavior Checklist Social Withdrawal subscale and in repetitive behaviors as measured by the Repetitive Behavior Scale. This study establishes the feasibility of IGF-1 treatment in PMS and contributes pilot data from the first controlled treatment trial in the syndrome. It also provides proof of concept to advance knowledge about developing targeted treatments for additional causes of ASD associated with impaired synaptic development and function.

Neural responsivity to tactile and auditory sensory stimuli in youth with and without ASD -- S. Green; D. Beck-Pancer ;L. M. Hernandez; J. J. Wood; J. D. Rudie; M. Dapretto and S. Y. Bookheimer, UCLA.

The extreme sensitivity to sensory stimuli often exhibited by children with autism may be caused by heightened responses in areas of the brain that process sensory stimuli and regulate emotion, according to a recent study at UCLA. Children with autism often avoid or become extremely upset in response to sensory stimuli, such as noisy environments or scratchy clothing. This condition is known as sensory over-responsivity (SOR) but until now, very little was known about why SOR occurs. In this study, first author Shulamite Green, M.A., along with senior authors Mirella Dapretto , Ph.D. and Susan Bookheimer, Ph.D., of UCLA, examined how children and adolescents with and without autism spectrum disorders responded to sensory stimuli in this case, noisy environmental sounds and being rubbed with a scratchy fabric while in a brain scanner. They found that the brains of youth with autism activate much more strongly in response to the slightl
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Contact: Adam Pockriss
apockriss@rubenstein.com
212-843-8286
Rubenstein Associates, Inc.
Source:Eurekalert

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