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The Helmholtz Association and Inserm create 2 joint research laboratories in France
Date:5/27/2011

d out by the team of Julien Marie, which demonstrated that growth factor TGF β could be a key molecule. The researchers from Inserm together with research groups of the DKFZ want to study the mechanisms of the TGF β activity involved in controlling the immune system. Employing some unique and powerful tools, they will use animal models and human samples obtained by biopsy to examine the cellular and molecular mechanisms by which TGF β makes it possible for tumour cells to escape control of the autoimmune system and recommend targets for therapeutic potential.

Julien Marie is a junior group leader at Inserm. Since 2010, he is the head of the ATIP-Avenir team "TGF-beta and immune evasion" at Lyons. After a three-year postdoctoral position at Seattle, he returned in 2006 to France under a young investigator grant by ANR (Agence Nationale de la Recherche).In 2010, he was awarded by the Bettencourt-Schuller Foundation a Coup d'lan prize for medical research.

At Marseilles, a second scientific project aims to endlessly renew specialized cells without the use of stem cells.

In most cases, once cells have acquired a specialized function (for example: neurons in the brain, muscle cells, macrophages in the immune system, etc.), they cease to divide and normally remain "locked" in this state until death. A team of scientists directed by Michael Sieweke has, however, achieved multiplication of murine macrophages, in vitro, by genetic modification. Moreover, once these modified cells are injected back into the animal, they behave normally; they do not form tumours and are entirely capable to carrying out the tasks expected of adult macrophages, such as ingestion of bacteria and secretion of chemical products to kill them. The collaboration with scientists of the MDC in Berlin will allow new experiments in order to better understand these phenomena which support specialist cell renewal without the involvement of stem cells.

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Contact: Priscille Riviere
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

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