Navigation Links
The GenoMEL project identifies a new region of the genome associated with the risk of melanoma
Date:7/6/2009

Research is increasingly becoming a networked process. The big genome studies are a good example of the need to pool the efforts of gold standard centers around the world. Only in this way is it possible to achieve results as solid as those obtained by the GenoMEL project, which is funded by the European Commission to study the genetic and environmental risk factors for melanoma. The objective is to translate this knowledge into recommendations based on evidence and healthier habits. The latest results obtained by this project, to published Online on Sunday in the journal Nature Genetics, have found a link between the risk of melanoma and two regions associated with skin pigmentation and a new region of the genome. GenoMEL is led by Leeds University and the IDIBAPS - Hospital Clnic of Barcelona researchers Dr. Susana Puig and Dr. Josep Malvehy are the only Spanish authors of this article.

Single-nucleotide polymorphisms (SNPs) are small variations in the sequence of nucleotides that make up DNA and can be associated with many genetic diseases. The study published in Nature Genetics performs an exhaustive search for SNPs in a broad population sample. The study enrolled 4336 control subjects and 1650 patients with melanoma and probable unknown genetic susceptibility. That is, patients with familial melanoma, multiple melanoma or melanoma before the age of 40 years who do not present mutations in the familial melanoma genes. The study was later replicated in a sample of 1163 patients and 903 controls in order to increase the solidity of the results. The statistical studies identified three regions in the genome with variations that represent a risk of developing melanoma. Two of these regions form part of the genes TYR and MCR1, associated with skin pigmentation and sensitivity to sunlight; they had already been identified in previous studies as risk factors. The third region is on chromosome 9 and represents a new risk factor that needs to be studied in detail in future research.

One of the strengths of this study is the fact that it was able to identify risk factors for developing melanoma that are shared by a population from around Europe and Australia. The three identified regions with genetic variations have a similar effect in all population groups, despite genetic variability and the large differences in the level of exposure to sunlight, depending on place of origin. This type of study provides better information on the etiology of a complex disease. Further study is required in the context of big international collaborations in order to find the causes and combat the disease.


'/>"/>

Contact: lex Argem, Scientific editor
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

Related medicine news :

1. Wounded Warrior Project (WWP) Seeks to Provide Mind, Body and Spirit Healing for Combat Stress
2. Allegiant Professional Business Services Inc. Signs New Members to Its PPO Health Insurance Plan. Annual Revenues Projected to Increase by $5M.
3. Kiwanis International Pursuing Second Worldwide Service Project
4. Marathon and Partners Announce Dramatic Results of Malaria Control Project on Bioko Island in Equatorial Guinea
5. Cardin Calls on NIH to Utilize Small Businesses for Extramural Research Projects
6. Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta
7. First Lady Michelle Obama and California First Lady Maria Shriver Kick Off 2009 National Conference on Volunteering & Service with Playground Service Project
8. McGill University receives almost $63 million under CFI program to support 5 research projects
9. National Council on Aging and Medicare Diabetes Screening Project Launch New Program to Educate Seniors about Medicares Benefits for Diabetes Screening
10. Wounded Warrior Project (WWP) Expands Board of Directors
11. Medicare, NW Denver Partners Launch Care Transitions Project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: