Navigation Links
The GenoMEL project identifies a new region of the genome associated with the risk of melanoma
Date:7/6/2009

Research is increasingly becoming a networked process. The big genome studies are a good example of the need to pool the efforts of gold standard centers around the world. Only in this way is it possible to achieve results as solid as those obtained by the GenoMEL project, which is funded by the European Commission to study the genetic and environmental risk factors for melanoma. The objective is to translate this knowledge into recommendations based on evidence and healthier habits. The latest results obtained by this project, to published Online on Sunday in the journal Nature Genetics, have found a link between the risk of melanoma and two regions associated with skin pigmentation and a new region of the genome. GenoMEL is led by Leeds University and the IDIBAPS - Hospital Clnic of Barcelona researchers Dr. Susana Puig and Dr. Josep Malvehy are the only Spanish authors of this article.

Single-nucleotide polymorphisms (SNPs) are small variations in the sequence of nucleotides that make up DNA and can be associated with many genetic diseases. The study published in Nature Genetics performs an exhaustive search for SNPs in a broad population sample. The study enrolled 4336 control subjects and 1650 patients with melanoma and probable unknown genetic susceptibility. That is, patients with familial melanoma, multiple melanoma or melanoma before the age of 40 years who do not present mutations in the familial melanoma genes. The study was later replicated in a sample of 1163 patients and 903 controls in order to increase the solidity of the results. The statistical studies identified three regions in the genome with variations that represent a risk of developing melanoma. Two of these regions form part of the genes TYR and MCR1, associated with skin pigmentation and sensitivity to sunlight; they had already been identified in previous studies as risk factors. The third region is on chromosome 9 and represents a new risk factor that needs to be studied in detail in future research.

One of the strengths of this study is the fact that it was able to identify risk factors for developing melanoma that are shared by a population from around Europe and Australia. The three identified regions with genetic variations have a similar effect in all population groups, despite genetic variability and the large differences in the level of exposure to sunlight, depending on place of origin. This type of study provides better information on the etiology of a complex disease. Further study is required in the context of big international collaborations in order to find the causes and combat the disease.


'/>"/>

Contact: lex Argem, Scientific editor
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

Related medicine news :

1. Wounded Warrior Project (WWP) Seeks to Provide Mind, Body and Spirit Healing for Combat Stress
2. Allegiant Professional Business Services Inc. Signs New Members to Its PPO Health Insurance Plan. Annual Revenues Projected to Increase by $5M.
3. Kiwanis International Pursuing Second Worldwide Service Project
4. Marathon and Partners Announce Dramatic Results of Malaria Control Project on Bioko Island in Equatorial Guinea
5. Cardin Calls on NIH to Utilize Small Businesses for Extramural Research Projects
6. Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta
7. First Lady Michelle Obama and California First Lady Maria Shriver Kick Off 2009 National Conference on Volunteering & Service with Playground Service Project
8. McGill University receives almost $63 million under CFI program to support 5 research projects
9. National Council on Aging and Medicare Diabetes Screening Project Launch New Program to Educate Seniors about Medicares Benefits for Diabetes Screening
10. Wounded Warrior Project (WWP) Expands Board of Directors
11. Medicare, NW Denver Partners Launch Care Transitions Project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... ... May 21, 2017 , ... Dental visits are often low ... you've seen a dentist, it's time for a dental checkup. The American Dental ... year. , Dental checkups are a relatively easy procedure that involves visually inspecting ...
(Date:5/19/2017)... , ... May 19, 2017 , ... ... health community, Queens University of Charlotte recently began recruitment efforts for the inaugural ... arms students with the skills, knowledge and expertise to approach and address the ...
(Date:5/19/2017)... ... May 19, 2017 , ... When Kyle Busch graduates from Kansas ... already appear on two major research studies that could impact the health of young ... Daggett, KCU alumnus and an orthopedic surgeon, alongside an international team trying to discover ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... The Hill ... to families and entrepreneurs throughout the California Central Valley, is announcing a joint charity ... raising community support for a local kid’s camp event. , The Boys and Girls ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... class of Beckman Young Investigators: , Victor Acosta, Ph.D. - University of New ... Dan Fu, Ph.D. - University of Washington, Erik Grumstrup, Ph.D. - Montana Stata ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... , May 15, 2017  Amy Baxter MD, ... industry leader in noninvasive pain relief, was awarded a ... magazine. Baxter was recognized at the MM&M Top ... New York City on May 10, 2017. ... the biopharma industry go "beyond the pill."  ...
(Date:5/12/2017)... , May 12, 2017  The China and Canada ... technology that consumes less water, energy and detergent, and features a ... product LaughingU, a shoebox-sized washing machine that washes and sanitizes women,s ... ... LaughingU, is compact, and does not require an external water inlet. ...
(Date:5/10/2017)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... quarter ended April 1, 2017 .   GAAP diluted ... to the prior year period as the sale of ... while non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue ... currency terms.  Excluding the effects of blood screening and ...
Breaking Medicine Technology: