Navigation Links
The GenoMEL project identifies a new region of the genome associated with the risk of melanoma
Date:7/6/2009

Research is increasingly becoming a networked process. The big genome studies are a good example of the need to pool the efforts of gold standard centers around the world. Only in this way is it possible to achieve results as solid as those obtained by the GenoMEL project, which is funded by the European Commission to study the genetic and environmental risk factors for melanoma. The objective is to translate this knowledge into recommendations based on evidence and healthier habits. The latest results obtained by this project, to published Online on Sunday in the journal Nature Genetics, have found a link between the risk of melanoma and two regions associated with skin pigmentation and a new region of the genome. GenoMEL is led by Leeds University and the IDIBAPS - Hospital Clnic of Barcelona researchers Dr. Susana Puig and Dr. Josep Malvehy are the only Spanish authors of this article.

Single-nucleotide polymorphisms (SNPs) are small variations in the sequence of nucleotides that make up DNA and can be associated with many genetic diseases. The study published in Nature Genetics performs an exhaustive search for SNPs in a broad population sample. The study enrolled 4336 control subjects and 1650 patients with melanoma and probable unknown genetic susceptibility. That is, patients with familial melanoma, multiple melanoma or melanoma before the age of 40 years who do not present mutations in the familial melanoma genes. The study was later replicated in a sample of 1163 patients and 903 controls in order to increase the solidity of the results. The statistical studies identified three regions in the genome with variations that represent a risk of developing melanoma. Two of these regions form part of the genes TYR and MCR1, associated with skin pigmentation and sensitivity to sunlight; they had already been identified in previous studies as risk factors. The third region is on chromosome 9 and represents a new risk factor that needs to be studied in detail in future research.

One of the strengths of this study is the fact that it was able to identify risk factors for developing melanoma that are shared by a population from around Europe and Australia. The three identified regions with genetic variations have a similar effect in all population groups, despite genetic variability and the large differences in the level of exposure to sunlight, depending on place of origin. This type of study provides better information on the etiology of a complex disease. Further study is required in the context of big international collaborations in order to find the causes and combat the disease.


'/>"/>

Contact: lex Argem, Scientific editor
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

Related medicine news :

1. Wounded Warrior Project (WWP) Seeks to Provide Mind, Body and Spirit Healing for Combat Stress
2. Allegiant Professional Business Services Inc. Signs New Members to Its PPO Health Insurance Plan. Annual Revenues Projected to Increase by $5M.
3. Kiwanis International Pursuing Second Worldwide Service Project
4. Marathon and Partners Announce Dramatic Results of Malaria Control Project on Bioko Island in Equatorial Guinea
5. Cardin Calls on NIH to Utilize Small Businesses for Extramural Research Projects
6. Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta
7. First Lady Michelle Obama and California First Lady Maria Shriver Kick Off 2009 National Conference on Volunteering & Service with Playground Service Project
8. McGill University receives almost $63 million under CFI program to support 5 research projects
9. National Council on Aging and Medicare Diabetes Screening Project Launch New Program to Educate Seniors about Medicares Benefits for Diabetes Screening
10. Wounded Warrior Project (WWP) Expands Board of Directors
11. Medicare, NW Denver Partners Launch Care Transitions Project
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric music video in ... footage and sound in the timeline and write in the lyrics to any song. ProLyric ... back out. Each line of the text can be added modularly for optimal control. ProLyric ...
(Date:6/25/2017)... ... , ... With a heatwave currently bearing down on Northern California pushing temperatures to the maximum, ... ready is easy with laser hair removal. , The process of summer waxing and ... when all you want to do is get out, dive in and cool off. There ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman and ... in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency dental ... dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with most ...
(Date:6/23/2017)... Alexandria, VA (PRWEB) , ... June 23, 2017 ... ... short of what is needed and will ultimately do significant harm to people ... care to everyone. , "While it leaves in place the Affordable Care ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America (MOAA) ... of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves as ... brings an intimacy with the issues and challenges veterans face with the VA. Following ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 6, 2017  Diplomat Specialty Infusion Group, a brand of Diplomat ... its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound intravenous ... low level of pollutants. "Our ... and better serve our Iowa patients," said ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings (NH), ... Recommended Solutions (VRS), and KD Pharma Group have decided ... Holdings by KD Pharma Group. KD Pharma Group will ... option to acquire the entire company. "We ... They are committed to growing the NH companies by ...
(Date:5/26/2017)... DUBLIN , May 26, 2017  Endo International plc ... Campanelli , President and CEO, will represent the Company in ... Global Healthcare Conference on Tuesday, June 13, 2017 at 10:40 ... held at Terranea Resort in Rancho Palos Verdes, ... archive for the event will be available on the Company,s ...
Breaking Medicine Technology: