Navigation Links
The Cancer Genome Atlas reports first results, Johns Hopkins Kimmel Cancer Center collaborates
Date:9/8/2008

The Cancer Genome Atlas (TCGA) has reported results from its first comprehensive study which focused on the deadly brain cancer glioblastoma.

The findings are reported in the Sept. 4, 2008, advance edition of Nature.

The TCGA team, comprised of more than 100 investigators from seven cancer centers and research institutions throughout the country, analyzed 601 genes in tumor samples from 91 glioblastoma multiforme (GBM) patients.

Investigators at the Johns Hopkins Kimmel Cancer Center and University of Southern California, members of the TCGA team, studied 2000 genes.

They reported findings on the MGMT gene, first linked to GBM in 1998 by Johns Hopkins investigators who found it was altered by a cellular process known as methylation. In 2002, they discovered that the gene alteration makes brain cancer cells more responsive to anticancer drugs known as alkylating agents.

While brain cancer patients with the MGMT alteration respond better to the commonly-used alkylating agent temozolomide, the new TCGA research found that treatment also appears to cause mutations in other genes, known as mismatch repair genes, essential to DNA repair. These mutations, they believe, lead to recurrence of the cancer, and these recurrent tumors contain unusually high numbers of gene mutations, making them resistant to treatment.

The investigators stress that treatment with temozolomide and radiation therapy is still the most effective therapy for glioblastoma patients.

"These current findings should help us devise new therapies that minimize the role MGMT plays in cancer recurrence," says Stephen Baylin, M.D., deputy director of the Johns Hopkins Kimmel Cancer Center and director of this portion of the TCGA study.

Brain cancer affects more than 21,000 people in the United States each year. GBM is the most common and lethal form of brain cancer, with most patients surviving just 14 months from the time of diagnosis.

The TCGA is funded by the National Cancer Institute (NIH) and National Human Genome Research Institute. The program began in 2006 to accelerate understanding of the molecular basis of cancer through full-scale, systematic studies of the human gene changes involved in all types of cancer. GBM is the first cancer studied under the program. A report of the complete findings from the study can be found on the National Cancer Institute's Web site.

"This type of comprehensive, coordinated analysis of unprecedented multidimensional data is made possible by advanced technologies utilized by teams of scientists driven to solve complex questions," said NCI director John E. Niederhuber, M.D. in a NIH statement. "It will now fall to a dedicated cadre of laboratory scientists to turn this important information into new life-saving therapies and diagnostics for cancer."


'/>"/>

Contact: Vanessa Wasta
mehlva@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... ... in Newburgh, New York, has recently begun offering three new minimally invasive procedures ... best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited to bring microneedling, ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has ... Dr. Talei has come up with a proprietary technique that he calls the ... that have dropped. For all ages, patients can expect to look refreshed, rejuvenated, and ...
(Date:6/23/2017)... ... 2017 , ... MD Now Urgent Care opened its newest location ... and marks the urgent care center's eighth location in Miami-Dade county. , The center's ... mall. The new clinic offers a wide array of services to patients ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus ... from 9 am to 3 pm to present to graduate students exciting new and ... an original curriculum project led by The Health Improvement Service of the Western Health ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... financial planning to families and business owners in North Central West Virginia, is ... provide services to differently abled residents in the region. , The Stepping Stones ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... , June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: ... call and webcast on Friday, July 28, 2017, beginning at ... Call Audio Only Dial-in information: To participate in the conference ... dial into the call at least 10 minutes prior to ... is 34090339.  Webcast: ...
(Date:6/16/2017)... June 16, 2017  Exactly 50 years ago today, the ... later became known as the San Francisco "Summer of Love."  ... unveiling two radical innovations in strategic market research portals that ... marks the beginning of Northern Light,s "Summer of Love (For ... ...
(Date:6/14/2017)... , June 14, 2017  In 2016, Embodied ... Startups pitch competition and came away with $25,000 ... is described by Forbes as "entering the life of ... Association as teaching "empathy to medical professionals in an ... was recently named a finalist for the Department of ...
Breaking Medicine Technology: