Navigation Links
The Cancer Genome Atlas completes detailed ovarian cancer analysis
Date:6/29/2011

support the existence of four distinct subtypes of the disease, based on the patterns seen in the transcription of RNA from DNA. They also support the existence of four related subtypes based on the patterns of DNA methylationa chemical reaction in which a small molecule called a methyl group is added to DNA, changing the activity of individual genes. These patterns likely reflect the functional changes associated with ovarian serous adenocarcinoma, but are not strongly associated with survival duration.

Mutations in BRCA1 and BRCA2 genes, which are associated with some forms of breast cancer, also confer increased risk for ovarian cancer. In this study, approximately 21 percent of the tumors showed mutations in these genes. Analysis of these tumors confirmed observations that patients with mutated BRCA1 and BRCA2 genes have better survival odds than patients without mutations in these genes. Importantly, investigators identified that the mechanism by which the BRCA1 and BRCA2 genes become defective also relates to survival. If either of the BRCA1 and BRCA2 genes is mutated, there is improved survival duration. However, if BRCA1 activity is instead reduced by methylation, there is no improved survival duration.

"The integration of complex genomic data sets enabled us to discover an intricate array of genomic changes and validate one specific change that occurs in the vast majority of all ovarian cancers," said lead author Paul T. Spellman, Ph.D., Lawrence Berkeley Lab, Berkeley, Calif. "Significantly, we have also found new information regarding the role that the BRCA1 and BRCA2 genes play in determining survival."

In this latest study, the TCGA researchers built upon the approach they used in 2008 to characterize the genome of gliobastoma multiforme, the most common form of brain cancer.


'/>"/>

Contact: NCI Office of Media Relations
NCIPressOfficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Two of Washington D.C.’s most ... through food and dining. , Recently named “the next big thing” in the ... known for telling the whole story behind food and reclaiming culinary traditions on the ...
(Date:9/1/2015)... ... September 01, 2015 , ... SC&H Group, a leading audit, tax, and ... a “Best of the Best” firm in the U.S., as well as being ranked ... the Best” in the U.S., selected exclusively on performance in specific areas of financial ...
(Date:9/1/2015)... ... , ... METTLER TOLEDO is pleased to announce that the ... EasySampler data is automatically transferred to, and reported with, the referring chemical synthesis ... EasySampler fully automates the sampling process including sampling capture, quench at ...
(Date:9/1/2015)... ... September 01, 2015 , ... Mercy Health (formerly Catholic Health Partners) ... of its monthly Mercy Health: Helping You Be Well videos to prostate cancer awareness. ... , In a concise video on Mercy Health’s YouTube channel, Mercy Health experts ...
(Date:9/1/2015)... ... 01, 2015 , ... Ogawa’s new massage chairs tout innovative functionality that change ... than ever before. With the goal of bringing wellness to the world, Ogawa introduces ... , As in its name, the Ogawa Refresh aims to “refresh” ...
Breaking Medicine News(10 mins):Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 3Health News:New Mercy Health Video Explains Most-Common Cancer Found in Men 2Health News:Ogawa World USA Releases New Massage Chairs to the US 2Health News:Ogawa World USA Releases New Massage Chairs to the US 3
... , TUESDAY, Feb. 1 (HealthDay News) -- Many black ... interaction stressful and don,t feel physicians give them enough useful ... suggests. The findings stem from a series of focus ... result: doctors are viewed as coming up short when it ...
... cancer cells dodge the immune system and promote tumor growth, ... disease. While comparable mechanisms to avoid the immune system have ... study tested human breast tumor cells, putting researchers closer to ... The study, published in the journal Cancer Research , ...
... targeted breast biopsies for patients with early breast cancer, ... from undergoing a second breast cancer surgery, a new ... undergo a sentinel lymph node biopsy to determine if ... author of the study. Ultrasound, on its own, ...
... , TUESDAY, Feb. 1 (HealthDay News) -- Finally some good ... with their parents behave better, have stronger mental health and ... study. Researchers at Brigham Young University,s School of Family ... to 16. They found that the most popular video games ...
... screening for breast cancer delivers consistent rates of cancer detection ... study published online and in the April print edition of ... than mammography at identifying suspicious areas of the breast, it ... lesions, which can result in additional testing and false-positive results ...
... published a new international multidisciplinary classification of lung adenocarcinoma, ... The new classification is published in the February ... the official publication of the International Association for the ... rapid advances in lung adenocarcinoma affecting clinical, radiologic, pathologic, ...
Cached Medicine News:Health News:Study Examines Reasons Some Black Men Avoid Doctors 2Health News:Breast cancer cells outsmart the immune system and thrive 2Health News:Breast cancer cells outsmart the immune system and thrive 3Health News:Microbubble ultrasound and breast biopsies 2Health News:Girls Win When They Play Video Games With Parents: Study 2Health News:Repeat MRI screening for breast cancer results in fewer false positives 2Health News:Lung societies unveil new international classification of lung adenocarcinoma 2
(Date:9/1/2015)... -- Within just two years after reaching a milestone ... 3,000 employees worldwide. This increase is reflecting a ... delivery market and SHL,s effective commitment, productivity and ... design and manufacturing of auto injectors and pen ... a lean supply chain, strong partnerships, and more. ...
(Date:9/1/2015)... , Aug. 31, 2015 Research ... addition of the "Introduction to Veterinary Pharmacovigilance ... their offering. This course has ... good introduction to those concerned with Veterinary Pharmacovigilance. ... personnel who reqire a better understanding of veterinay ...
(Date:9/1/2015)... 2015 - The ... egistry data presented at ESC Congress ... the evolution of manag ing AF in ... -   The first-ever two-year outcomes from the Global Anticoagulant ... expose that all-cause death was the most frequent major event in more than ...
Breaking Medicine Technology:SHL Group Reaches Major Milestone of 3000 Employees 2Introduction to Veterinary Pharmacovigilance Seminar (London, UK - September 23-24) 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9
... 2012  Before purchasing electronic health records software ... management features, supported architectures and the ONC-ATCB certification ... consists of health information compiled from multiple health-oriented ... contains a patient,s medical information from one organization, ...
... Inc. (NYSE: PRX ) announced today that it will ... 2012 at 9:00 AM EST to review results for the fourth ... results on February 28, 2012 before the market opens. ... website at www.parpharm.com . Dial-in Information ...
Cached Medicine Technology:Let FindTheBest Help You Choose The Best Electronic Health Record Software 2
Anterior Interbody fusion with proven clinical performance. Large hole design. Request info fda status for sale....
... images are transmitted through sorted ... picture and transmit it to ... flexoscopes are designed for rough, ... repaired at low cost if ...
The flexible endoscope was mainly developed for the pure neuroendoscopy. Due to the working channel it is ideal suitable for therapeutic indications e.g. subdural hematomas, cysts or intraventricular...
The original Zeppelin High-Speed Motordrill System has been developed to rapidly cut bone, plastic and metal with utmost precision. 120-150 psi - 90.000 rpm - 90g - autoclavable at <134 C....
Medicine Products: