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The BioProcess International September Issue - Now Available in Print, Digital and Mobile App Editions
Date:9/30/2013

New York, NY (PRWEB) September 30, 2013

BioProcess International (BPI) announces the publication of the BioProcess International September 2013 issue featuring the following articles and special reports:

Focus on Regenerative Medicine

The components used to make a cell- and tissue-based product can vary greatly in source, complexity, and manufacturing. Ancillary materials can have a profound effect on the expansion, differentiation, or activity of a cell or tissue product and thus significantly affect its quality attributes. Ensuring the quality of a cell- or tissue-based therapeutic requires rigorous evaluation of the components used in its manufacture. As the authors report in this article, USP test specifications and physical reference standards can help.

Special Report: Protein A

Because of the inherent and engineered variations in therapeutic antibody structures, there is no “one-size-fits-all” when it comes to techniques for MAb purification. The closest anything has come to this is evidenced by the success of protein A affinity chromatography, which has become the workhorse for antibody production. But it is not the perfect solution. Some experts refer to new alternatives as “disruptive,” while predicting that protein A will continue to be used for commercial-scale MAb purification throughout the foreseeable future. In this article, Blanca Lain looks at the history of protein A in MAb purification (also drawing on responses from a BPI survey) and explores various perspectives on its continued role in bioprocessing as well as potential alternatives.

BPI Lab: Spectroscopy

Well known for its utility in raw-materials testing, spectroscopy has extended itself throughout bioprocess development in various forms (e.g., NMR , Raman, and FTIR). In this article, senior technical editor Cheryl Scott explores the history, commonly used methods, and many applications of spectroscopy in bio
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