Navigation Links
The 'Bear' Facts on Obesity and Diabetes
Date:8/5/2014

TUESDAY, Aug. 5, 2014 (HealthDay News) -- The ways grizzly bears deal with hibernation and fluctuating weight might offer valuable new clues to human obesity and diabetes, new research suggests.

The study authors note that the tissues of obese people with type 2 diabetes become dangerously insensitive to insulin, the hormone that helps control the level of sugar in the blood.

However, unlike people, insulin levels in grizzly bears do not change, the researchers found. Instead, the bears' cells seem to be able to control their ability to respond to insulin.

In fact, in the fall -- when grizzly bears are most obese -- they are also the most sensitive to insulin, says a team led by Dr. Kevin Corbit, of the drug maker Amgen, Inc.

According to Corbit's group, this happens because the activity of a key protein found in fat cells, called PTEN, is shut down.

In fact, weeks into hibernation, grizzly bears develop a "natural" state of diabetes that is cured when they wake up in the spring, according to the study, which is published Aug. 5 in the journal Cell Metabolism.

During hibernation, grizzly bears also store the fuel their bodies need to survive the winter in fat tissue. In other obese animals however, fat builds up in the liver and muscles, Corbit's team pointed out.

The bear findings are "in contrast to the common notion that obesity leads to diabetes in humans," Corbit said in a journal news release. In fact, the finding suggests that obesity and diabetes "may exist naturally on opposite ends of the metabolic spectrum," he said.

Corbit stressed that these findings have yet to be borne out in humans. However, "we believe that these and other data do support a more comprehensive and perhaps holistic approach to caring for patients with diabetes and/or obesity," he said.

His team believes that the mechanisms that lead to obesity in some people -- such as lower levels of PTEN -- might also protect them from diabetes. On the other hand, what leads other people to develop diabetes might also protect them from becoming obese.

"This more sophisticated understanding of the relationship between diabetes and obesity should enable researchers not only to develop therapies targeting these mechanisms, but also to identify the appropriate patients to whom these therapies should be targeted," Corbit said.

More information

There's more on type 2 diabetes at the American Diabetes Association.

SOURCE: Cell Press, news release, Aug. 5, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. People May Eat More When Headlines Bear Bad News
2. Backs bear a heavy burden
3. Dr. Polo to Offer Much-Anticipated, New Gummy Bear Implants for Superior Breast Augmentation and Breast Reconstruction
4. BeardedEagle Presents Pay It Forward Friday in Oklahoma City, OK
5. Certified ScrumMaster May 9-10 in Houston presented by BeardedEagle
6. FDA Approves New “Gummy Bear” Breast Implants, But Albany Plastic Surgeon Urges Caution
7. PMI-ACP Exam Prep Boot Camp May 22-24 in Tampa Presented by BeardedEagle
8. ChopChop Children's Food Magazine Wins Coveted Beard Award
9. Obese students childbearing risk varies with high school obesity rates
10. Golf Tournament at The Bear’s Club Raises $1.3 Million for South Florida Foundation
11. Premier Plastic Surgery Arts Now Offers Gummy Bear Implants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The 'Bear' Facts on Obesity and Diabetes
(Date:5/27/2016)... ... May 27, 2016 , ... ... in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation ... providing proof of successfully certified products, services and staff. , Validation Center is ...
(Date:5/26/2016)... ... 26, 2016 , ... Intalere, the healthcare industry leader in ... inaugural Member Conference at the Paris Hotel in Las Vegas, Nev., May 17-20, ... America’s healthcare providers. , The conference was highlighted by the announcement of the ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia ... negative impact on long-term patient survival, reports a team of UPMC researchers in ... week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... An April ... American families. , The 550 employees of Sun Health Senior Living (SHSL) ... Aetna that reduces their doctor and prescription copays for the year, while holding the ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute ... a six-week smoking cessation class starting June 6 at their clinic in downtown Tampa. ... . , Additionally, the Lung Institute has created a free downloadable 4 Week ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... H1 2016"market research report that provides an overview ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:5/24/2016)... Cirujanos holandeses han puesto en ... médicos a compartir sus mejores prácticas por el mundo ... médicos de Europa, África, Asia ... aplicación, que combina la transmisión en vivo con mensajería ... Educación   "Imagine un médico de Medicines ...
(Date:5/24/2016)... 24, 2016   , ... in overall bowel cleansing and superiority in ... leansing of the ascending ... , Norgine B.V. today announced new positive data from ... ascorbate bowel preparation) versus standard 2 litre PEG with ascorbate. The ...
Breaking Medicine Technology: