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Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
Date:12/9/2007

neuropathy, neutropenia, and depression were observed in the MP-T arm of the study, no significant differences in rates of deep venous thrombosis or somnolence were found between the treatment arms. Toxicities in the MP-T arm were considered acceptable in this very elderly population.

"While the MP-T treatment regimen has become a standard treatment for newly diagnosed patients with multiple myeloma up to 75 years of age, those older than 75 represent more than 20 percent of myeloma patients, and are frequently excluded from large-scale clinical trials," said Cyrille Hulin, M.D., on behalf of the Intergroupe Francophone du Myelome and a principal investigator of the trial. "These are the first data to demonstrate the therapeutic benefit of the addition of thalidomide to MP for patients over age 75, which together with other recent data, demonstrate that MP-T therapy should become the reference treatment for all patients older than 65 years with newly-diagnosed multiple myeloma."

Pharmion submitted an application to the European Medicines Agency (EMEA) in January 2007 for a marketing authorization application for Thalidomide Pharmion in combination with melphalan and prednisone as first line treatment of patients with untreated multiple myeloma, aged 65 years or older or ineligible for high dose chemotherapy.

Thalidomide Data at ASH

Date / Time / Location: December 9, 2007; 4:30-6:00 p.m.; Rooms C303-C305, Georgia World Congress Center
Session: Myeloma: Firstline Phase III Trials in Multiple Myeloma

-- Oral Presentation - 4:30 p.m.: Velcade-Thalidomide-Dexamethasone (VTD)

vs Thalidomide-Dexamethasone (TD) in Preparation for Autologous Stem-

Cell Transplantation (ASCT) in Newly Diagnosed Multiple Myeloma

(Abstract #73).

-- Oral Presentation - 5:00 p.m.: Melphalan-Prednisone-Thalidomide (MP-T)

Demonstrates a Significant Survival Advantage in Elderly Patients .75

years wi
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SOURCE Pharmion Corporation
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