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Thalidomide Added to Standard Therapy Prolongs Overall Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
Date:12/9/2007

- Data Demonstrate 17.6 Month Overall Survival Advantage in Elderly Myeloma

Patients when Thalidomide Is Added to Standard Therapy

- Data Presented at the 49th American Society of Hematology Meeting

ATLANTA, Dec. 9 /PRNewswire-FirstCall/ -- Pharmion Corporation (Nasdaq: PHRM) today announced final data from a randomized, double-blind, placebo-controlled Phase 3 trial demonstrating that the addition of Thalidomide to standard treatment improves survival by 17.6 months in patients over age 75 newly diagnosed with multiple myeloma compared to standard treatment, consisting of melphalan-prednisone (MP), alone. These data, along with results from 12 additional studies of Thalidomide, are being presented at the 49th Annual Meeting and Exposition of the American Society of Hematology (ASH) in Atlanta.

"These data further demonstrate that the addition of Thalidomide to standard first-line therapy for patients with multiple myeloma, even relatively elderly patients, can provide a significant overall survival benefit," said Patrick J. Mahaffy, president and chief executive officer of Pharmion. "Data from this study are fully consistent with those previously announced and which form the basis of the Company's current marketing authorization application with the European regulatory authorities."

The Phase 3 dual-arm randomized study compared overall survival in patients receiving standard therapy of melphalan and prednisone plus placebo (MP-placebo) or standard therapy plus Thalidomide (MP-T). A total of 232 patients were randomized to one of the two treatment arms and 229 were analyzed for the presentation. In the analysis, the median overall survival in the MP-T arm was 45.3 months, compared to 27.7 months for the MP-placebo (p=0.033 log-rank test). Median progression-free survival was significantly higher in the MP-T arm, 24.1 months, compared to 19 months for the MP-placebo arm (p=0.001).

Though increased rates of peripheral
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SOURCE Pharmion Corporation
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