Navigation Links
Texas researcher: Peaches inhibit breast cancer metastasis in mice
Date:3/25/2014

COLLEGE STATION Lab tests at Texas A&M AgriLife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.

AgriLife Research scientists say that the mixture of phenolic compounds present in the peach extract are responsible for the inhibition of metastasis, according to the study, which was this month published in the Journal of Nutritional Biochemistry.

"Cancer cells were implanted under the skin of mice with an aggressive type of breast cancer cells, the MDA-MB-435, and what we saw was an inhibition of a marker gene in the lungs after a few weeks indicating an inhibition of metastasis when the mice were consuming the peach extract," said Dr. Luis Cisneros-Zevallos, a food scientist for AgriLife Research in College Station. "Furthermore, after determining the dose necessary to see the effects in mice, it was calculated that for humans it would be equivalent to consuming two to three peaches per day."

This is very important because it can be translated into something that is also beneficial for people, he added.

This work builds upon previous work at AgriLife Research released a few years ago, which showed that peach and plum polyphenols selectively killed aggressive breast cancer cells and not the normal ones, Cisneros-Zavallos said.

The previous work as well as the present one was conducted by Cisneros-Zevallos, Dr. David Byrne, both with AgriLife Research; Dr. Weston Porter, Texas A&M University department of veterinary physiology and pharmacology; and then-graduate student Giuliana Noratto, who is now on the faculty at Washington State University.

In the western hemisphere, breast cancer is the most common malignant disease for women, he said. In the U.S. last year, the American Cancer Society estimated about 232,340 new cases of invasive breast cancer among women.

Most of the complications and high mortality associated with breast cancer are due to metastasis, Cisneros-Zevallos pointed out.

"The importance of our findings are very relevant, because it shows in vivo the effect that natural compounds, in this case the phenolic compounds in peach, have against breast cancer and metastasis. It gives opportunity to include in the diet an additional tool to prevent and fight this terrible disease that affects so many people," he said.

The study was conducted using the peach variety Rich Lady. However, according to Cisneros-Zevallos, most peach fruit share similar polyphenolic compounds but might differ in content. The study also determined that the underlying mechanism by which peach polyphenols are inhibiting metastasis would be by targeting and modulating the gene expression of metalloproteinases.

"In general, peach fruit has chemical compounds that are responsible for killing cancer cells while not affecting normal cells as we reported previously, and now we are seeing that this mixture of compounds can inhibit metastasis," said Cisneros-Zevallos. "We are enthusiastic about the idea that perhaps by consuming only two to three peaches a day we can obtain similar effects in humans. However, this will have to be the next step in the study for its confirmation."

Cisneros-Zevallos continues testing these extracts and compounds in different types of cancer as well as in diabetes studies in vitro and in vivo to understand the molecular mechanisms involved.


'/>"/>

Contact: Kathleen Phillips
ka-phillips@tamu.edu
979-845-2872
Texas A&M AgriLife Communications
Source:Eurekalert  

Related medicine news :

1. UTMB receives $3.2 million to continue collaborative research on cancer in Texas
2. Verb Spins Out of the University of Texas at Austin
3. The Texas Pain Relief Group (TPRG) and Physicians Partners of America (PPOA) Announce the Opening of Clinics in Plano and Hurst
4. Texas Children’s Hospital West Campus Recognized as Top Children’s Hospital by The Leapfrog Group
5. First Choice Emergency Room Opens 26th Facility in La Porte, Texas
6. Woodbolt International Named One of the ‘Best Companies to Work for in Texas’
7. Appilicious's Plan4Life Day Planner App Is Selected by University of Texas McCombs School of Business’ Graduate Development Program
8. Obesity Algorithm Now Available to Help Physicians Treat & Care for Patients; Dr. Jenny Seger and BMI of Texas Announce Support for ASBP’s New Tool
9. Richard Scrushy to Speak at the Healthcare Financial Management Association, Texas Gulf Coast Winter Institute
10. First Choice Emergency Room Names Dr. Michael Romanko Medical Director of La Porte, Texas Facility
11. Fill Texas Dental Jobs Now Before the Year-End Rush
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Texas researcher: Peaches inhibit breast cancer metastasis in mice
(Date:1/24/2017)... ... January 24, 2017 , ... ... technology offering, Processing Assurance Control Equipment (PACE), at the International Production and Processing ... PeroxyChem’s booth will highlight the new technology that is used in poultry processing ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... to the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by ... 12th year in 2017. The entrepreneurs will showcase their businesses on February 6, ...
(Date:1/24/2017)... ... , ... Bellus Medical, a leader in medical aesthetics, today announced that Marek ... Dr. Dobke will provide physician oversight for in-house clinical studies and hands-on device training, ... and Associate Professor of Surgery at UC San Diego Health and is a board ...
(Date:1/24/2017)... ... 2017 , ... Inspiration, Community & Mentorship – Top Students ... Fordham Institute’s High Stakes for High Achievers offer recommendations for how ... high-achieving students as a subgroup and reporting their results separately. Top students and ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... unveiled its latest award-winning bottles, designed specifically to optimize the drinking experience for ... Agua is renowned for introducing the world’s first untouched bottled water purposed exclusively ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... and PUNE, India , January 24, ... by Allied Market Research, titled, "Acidity Regulators Market - ... market for acidity regulators was valued at $4,456 million in 2015, ... a CAGR of 7.96% from 2016 to 2022. Asia-Pacific ... to maintain its lead, followed by North America ...
(Date:1/24/2017)... SAN FRANCISCO , January 24, 2017 ... reach a value of USD 3.8 billion by 2025, ... Inc. The market growth can be attributed to the ... awareness about early diagnosis of micro calcifications in breast ... Cancer Foundation, CDC, and Breast Cancer Organization are promoting ...
(Date:1/24/2017)... For today, Stock-Callers.com scans the following Biotechnology companies: ... Inc. (NASDAQ: ALDR ), BioDelivery Sciences International Inc. ... EGLT ). These equities are part of the Healthcare ... , 2017, with the NYSE Health Care Index dropping about ... 500 also were down 0.3% as a group. These stocks ...
Breaking Medicine Technology: