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Tet further revealed: Studies track protein relevant to stem cells, cancer
Date:3/30/2011

CHAPEL HILL, N.C. Last year, a research team at the University of North Carolina at Chapel Hill discovered one way the protein Tet 1 helps stem cells keep their pluripotencythe unique ability to become any cell type in the body. In two new studies, the team takes a broad look at the protein's location in the mouse genome, revealing a surprising dual function and offering the first genome-wide location of the protein and its product, 5-hydroxymethylcytosinedubbed the "sixth base" of DNA.

UNC biochemist Yi Zhang, PhD, whose team conducted the studies, called the findings an important step in understanding the molecular mechanisms behind cell differentiation and the development of cancer. The findings appear in two recent papers, published March 30, 2011 online in Nature and in the April 1, 2011 issue of Genes & Development.

"There is no doubt that Tet proteins are relevant to cancer," said Zhang, Kenan distinguished professor of biochemistry and biophysics. Zhang is also an investigator of the Howard Hughes Medical Institute and a member of the UNC Lineberger Comprehensive Cancer Center. Tet proteins were initially discovered in leukemia as fusion proteins, which are commonly found in cancer cells, where they may function as oncoproteins.

In addition, Zhang said, "Tet is likely to be one of the important players for stem cell reprogramming." Learning to "reprogram" cells in the adult body to make them behave like stem cells has long been a goal for stem cell researchers; understanding how Tet proteins operate could help advance stem-cell based treatments.

Tet proteins are known to help stem cells stay pluripotent. Zhang's team analyzed Tet1's occupancy across the entire mouse embryonic stem cell genome. They found that the protein works by using a two-pronged approach to maintain the mouse embryonic stem cell state.

"On one hand, it silences the genes that are important for differentiation. On the othe
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Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

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