Navigation Links
Tests in mice identify compound that may keep survivors of brain aneurysms from succumbing to stroke
Date:10/1/2013

Johns Hopkins researchers, working with mice, say they have identified a chemical compound that reduces the risk of dangerous, potentially stroke-causing blood vessel spasms that often occur after the rupture of a bulging vessel in the brain.

They say their findings offer clues about the biological mechanisms that cause vasospasm, or constriction of blood vessels that reduces oxygen flow to the brain, as well as potential means of treating the serious condition in humans.

When an aneurysm essentially a blister-like bulge in the wall of a blood vessel bursts, blood spills into the fluid-filled space that cushions the brain inside the skull. If a patient survives a ruptured aneurysm, between 20 and 40 percent of the time, this brain bleed, called a subarachnoid hemorrhage, will lead to an ischemic stroke within four to 21 days, even when the aneurysm is surgically clipped.

"We're a long way from applying this to humans, but it's a good start," says Johns Hopkins neurosurgery resident Tomas Garzon-Muvdi, M.D., M.Sc., one of the authors of the study led by Rafael J. Tamargo, M.D., and described in the October issue of the journal Neurosurgery.

To conduct their experiments, Garzon-Muvdi and his colleagues took blood from mouse leg arteries and injected it behind their necks to mimic what happens in a subarachnoid hemorrhage. Then they gave the mice a compound called (S)-4-carboxyphenylglycine (S-4-CPG), a placebo or nothing at all. The mice given S-4-CPG developed less vasospasm, looked better and were more active than those in the other two groups.

The scientists also found concentrations of the drug in the brains of the mice, showing that it was able to cross the often impermeable blood-brain barrier. The researchers chose the compound because it is similar to drugs that have been used in stroke research in rodents. It is not approved for any use in humans.

Garzon-Muvdi explains that when blood ves
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Physician Groups Call for Fewer Medical Tests
2. Range of diagnostic spinal fluid tests needed to differentiate concurrent brain diseases
3. URMC clinical trial tests new regimen for hypertension
4. Smell Tests Dont Predict Alzheimers, Study Finds
5. Are Post-Angioplasty Stress Tests Unnecessary?
6. OSHAs Safety Tests Protect Workers at Little Cost: Study
7. Gene Tests May Not Drive Patients to More Medical Care
8. Better tests for sleeping sickness
9. U.S. Advisers Say No to Routine PSA Tests for Prostate Cancer
10. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
11. Super-sensitive tests could detect diseases earlier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Low market concentration, low price volatility, high ... the market for packaging design services. These factors foster ... indicating a moderate level of buyer power. “This level ... equal amount of leverage during negotiations,” according to IBISWorld ... exist for packaging design services . Buyers need ...
(Date:8/20/2014)... August 20, 2014 First Choice ... emergency rooms in the United States, named Richard Daniels, ... FM 685 facility. , “We are pleased to ... director of our second facility in Pflugerville,” said Dr. ... Emergency Room. , Dr. Daniels received his undergraduate ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 Kowa ... Expo West show to debut the new SL-17 portable ... a 20,000 lux white LED source controlled by an ... examination rooms. The SL-17 uses commercially available AAA rechargeable ... the previous SL-15 design requiring batteries designed specifically for ...
(Date:8/20/2014)... 20, 2014 This agreement will ... software defined networking, high availability cloud enablement, service, ... Resellers, while allowing OPEN-V to sell storageFOUNDRY’s expanding ... to work with OPEN-V on this distribution agreement ... manager distribution channels at storageFOUNDRY. "Nautilus is a ...
(Date:8/19/2014)... in Houston, Texas, is pleased to announce it is now ... with old fillings that need replacing, will benefit from the ... teeth. , From now on any cavities will be repaired ... amalgam free. Even though amalgam fillings have been deemed as ... children over the age of six, they do contain mercury ...
Breaking Medicine News(10 mins):Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 4Health News:First Choice Emergency Room Announces Dr. Richard Daniels as Medical Director of the Pflugerville – FM 685 Facility 2Health News:Kowa Optimed (Booth MS13043) to Debut New Portable Slit Lamp at 2014 Vision Expo West in Las Vegas, Nevada 2Health News:storageFOUNDRY and Open-V OzoneStack Announce Bilateral Distribution Agreement 2Health News:storageFOUNDRY and Open-V OzoneStack Announce Bilateral Distribution Agreement 3Health News:Midtown Dentistry Announces It Is Now an Amalgam-Free Office 2
... Sudden Cardiac Arrest,Association (SCAA) has appointed Chris Chiames as ... Chris join SCAA as we begin to implement our,strategic ... our goal of,eliminating preventable sudden cardiac arrest deaths (SCA) ... SCAA Board of Directors.,"Advancements in medical technology and treatment ...
... Sept. 7 With safety issues making,headlines, ... rugged,regulatory landscape. Organizations are relying on their ... affect production. Proper,staffing of quality roles is ... and a study by pharmaceutical benchmarking leader ...
... Employees Start! Lacing Up Their Walking Shoes -, ... fight against sedentary lifestyles by participating in the,American ... promote,walking and other healthy habits in the workplace. ... a Start! "walkforce" team to,participate in today,s Wilmington ...
... BELLEVILLE, ON, Sept. 7 /PRNewswire-FirstCall/ - Bioniche ... Canadian,biopharmaceutical company, today announced that it has ... Economic Development (RED) Program of the,Ontario Ministry ... grant,announced by the Honourable Leona Dombrowsky, Minister ...
... be compromised by new provisions enabling commercial companies to ... , A study, led by the Centre for International ... that, as a result of changes to how ... to provide patients with integrated and comprehensive services. , ...
... This week, American Red,Cross President and CEO, Mark W. ... of Operations Support., In this role, Sean will ... and Diversity, Finance and Information Technology to,ensure optimal integration ... of business., "The Red Cross will benefit from ...
Cached Medicine News:Health News:Corporate and Political PR Pro to Lead Sudden Cardiac Arrest Association 2Health News:Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance 2Health News:AstraZeneca Leads Local Walking Movement 2Health News:AstraZeneca Leads Local Walking Movement 3Health News:AstraZeneca Leads Local Walking Movement 4Health News:Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine 2Health News:Care reforms raise concerns over patient access to GP services 2Health News:Sean P. McLaughlin Joins Red Cross as Chief of Operations Support 2
(Date:8/19/2014)...  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will webcast management ... and Regeneron will host an IR Thematic Conference Call on Alirocumab ... 2014 , Baird 2014 Healthcare Conference at 4:05 ... , Citi,s 9 th Annual Biotech Conference at ... , Morgan Stanley Global Healthcare Conference at 8:45 ...
(Date:8/19/2014)... Luoxis Diagnostics, Inc. , a ... MKT: AMPE), today announced an upcoming presentation at ... American Academy of Surgical Trauma (AAST) and Clinical ... Philadelphia, Pennsylvania that will be held ... from a recently completed five-year prospective clinical trial ...
(Date:8/19/2014)... ALBANY, New York , August 19, 2014 /PRNewswire/ ... " Surgical Navigation Systems Market (Neurosurgical Navigation Systems, ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2014 ... valued at USD 218.5 million in 2013 and is ... 2014 to 2020, to reach an estimated value of ...
Breaking Medicine Technology:Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 2Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 2Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 4Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 5Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 6Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 7Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 8Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 9
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: