Navigation Links
Testosterone-regulated genes may affect vaccine-induced immunity
Date:12/23/2013

WHAT:

A new study has identified a link between certain genes affected by testosterone and antibody responses to an influenza vaccine. The findings, published in Proceedings of the National Academy of Sciences, suggest that testosterone levels may partially explain why men often have weaker responses to vaccines than women. The study, led by researchers at Stanford University, was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health.

Previous research has shown that men typically experience more severe viral and other microbial infections than women, who tend to mount stronger immune responses to infections and vaccinations. In the new study, researchers analyzed the antibody responses of 53 women and 34 men of various ages to the 2008-2009 seasonal influenza vaccine. Compared to the men, the women produced antibodies that in laboratory tests could more effectively neutralize the influenza virus.

To explain this difference, the scientists searched for patterns in gene expression, or the degree to which specific genes are turned on or off. They found that men with weak vaccine responses tended to have high expression levels of a certain cluster of genes involved in the metabolism of lipids (fats). Previous studies have suggested that testosterone may regulate the expression of many of these genes. The researchers found that men with high levels of testosterone and elevated expression of the gene cluster had weaker antibody responses to the vaccine than women and men with low testosterone. These results suggest that testosterone may suppress immune responses to vaccines by altering expression patterns of specific genes, but further research is needed to determine the mechanism.


'/>"/>

Contact: Press Office
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers ID Genes That May Determine Mental Illness
2. 2 repressor genes identified as essential for placental development
3. Genes Associated With Autism Also Related to Schizophrenia
4. Genes Might Cause Some to Shun Pork
5. Blond Genes May Vary Around the World
6. Mystery of the missing breast cancer genes
7. Living longer - variability in infection-fighting genes can be a boon for male survival
8. Genes Might Be Key to Parkinsons Spread
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Study Ties Genes to Lower Urinary Tract Symptoms, Prostate Cancer Risk
11. Obesity genes may influence food choices, eating patterns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... MA (PRWEB) , ... August 17, 2017 , ... ... will come together on September 19, 2017 for Anti-Infectives Rx. This off-the-record networking ... B. Martin Conference Center at Harvard Medical School. , Industry leaders and decision ...
(Date:8/17/2017)... City, Utah (PRWEB) , ... August 17, 2017 , ... ... share how to efficiently and effectively grow a dental practice in a competitive market ... hours of dental C.E. that could just transform you and your practice.” says Daniel ...
(Date:8/17/2017)... ... August 17, 2017 , ... The 2017 ... and healthcare systems to interact with their GPO and supplier partners. This year, ... BCN, CVAHP, System Director of Clinical Value Analytics, have been invited to present ...
(Date:8/17/2017)... ... August 17, 2017 , ... Aeroflow Healthcare today announced ... America’s fastest growing private companies. Inc. magazine ranked Aeroflow Healthcare #2450 on its ... , The Inc. 5000 represents the most comprehensive study of American entrepreneurial ...
(Date:8/17/2017)... Prairie, Minnesota (PRWEB) , ... August 17, 2017 , ... ... business publication has ranked the multichannel growth agency among the fastest-growing private companies in ... the tens of thousands of companies that have applied to the Inc. 5000 ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... FLINT, Mich. , July 31, 2017  Diplomat Pharmacy, ... companies in southeast Michigan by ... feature ranks private and public companies by three-year revenue growth. ... To view the complete list, ... Crain,s Fast 50 is an incredible triumph," said Phil ...
(Date:7/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: ... quarter ended June 30, 2017, and updated its financial ... For the fiscal third quarter, Hill-Rom reported ... per diluted share in the prior-year period. These results ... per diluted share primarily related to the non-cash write-down ...
(Date:7/27/2017)... July 27, 2017  West Pharmaceutical Services, Inc. (NYSE: ... for the second-quarter 2017 and updated financial guidance for ... Second-Quarter 2017 Highlights Reported net sales ... the prior-year quarter. Net sales at constant currency (organic) ... EPS was $0.51, compared to $0.60 in the prior-year ...
Breaking Medicine Technology: