Navigation Links
Testosterone isn't the help some hoped for when women go through menopause early

CLEVELAND, Ohio (January 29, 2014)With plummeting hormone levels, natural menopause before age 40 can put a damper on women's mental well being and quality of life. But bringing testosterone back up to normal may not bring them the boost some hoped for, found a new study published online today in Menopause, the journal of The North American Menopause Society (NAMS).

Before age 40, ovaries stop functioning in about 1% of women without some obvious genetic abnormality to blame, bringing on an early menopause. Called "primary ovarian insufficiency" or POI, the condition can spell not only infertility and other physical problems but also depression and decreased quality of life. Adding back lost estrogen and progesterone helps. But ovaries normally produce testosterone, too, which has mental and physical effects. Adding it back, some thought, could be helpful.

But studies looking at adding testosterone for women who lose ovarian function for other reasons, such as after natural menopause or hysterectomy, haven't yielded consistent results. So these investigators looked at the mood and quality of life data from women with POI in a study done at the National Institutes of Health Clinical Center in Bethesda, MD, where women underwent a year of hormone therapy that included testosterone. In the randomized, double-blind, placebo controlled study, 61 women used placebo patches and 67 women used patches that delivered 150 micrograms of testosterone a day, similar to the Intrinsa patch that was rejected by FDA as a treatment for low sexual desire in women.

After 12 months, testosterone levels were back up to normal for the women who got the treatment. The investigators saw no detrimental effects of testosterone, but they found no significant improvement either in measurements of quality of life, self esteem and mood compared with placebo.

Bringing testosterone back to normal doesn't help these aspects of life, suggesting that it's something other than testosterone that plays a role in mood problems for women with POI, concluded the researchers.

But there are still unknowns. The study didn't measure depression and sexual function specifically, so the investigators couldn't draw conclusions about the effects of normalizing testosterone on those problems. Having some effect on desire may take raising testosterone to higher-than-normal levels, according to some studies, although that poses questions about safety.

"This study makes an important contribution toward understanding what testosterone can and cannot do. With all the hype about testosterone and aging, it is important that the public have the facts," says NAMS Executive Director Margery Gass, MD.


Contact: Eileen Petridis
The North American Menopause Society (NAMS)

Related medicine news :

1. Testosterone-regulated genes may affect vaccine-induced immunity
2. How to Increase Testosterone Levels Naturally Discussed in New Video by Diet Recommendations
3. A New “11 Ways To Increase Testosterone” Article Helps Men Boost Testosterone Levels Naturally – V-kool
4. Hysterectomized women may benefit from testosterone
5. Testosterone Therapy Safety a Top Priority at AAG Health
6. Study finds testosterone therapy may reduce risk of cardiovascular disease
7. Global Testosterone Market 2012 - 2016 : Worldwide Industry Latest Market Share,Investment Trends, Growth, Size,Trends , Strategy And Forecast Research Report 2016
8. The Complete Testosterone Solution: Review Examining Dan Robey's New Fitness System Released
9. Now Offers the Customers a Discount of 50% With the Purchase of Men’s Health Formula Pro Testosterone
10. ANY LAB TEST NOW® Launches New Pre-Testosterone Replacement Therapy and Continued Testosterone Replacement Therapy Lab Testing Panels
11. Pro Testosterone: The Secret to Endless Youthfulness and Vigor Finally Revealed
Post Your Comments:
(Date:11/25/2015)... ... ... In an ongoing Clinical Study conducted by an independent physician, Andrew Gostine, ... evaluating the efficacy of its product and its disinfection protocol. This study is taking ... 2014 through October 2015 at a 360-bed, acute-care, academic medical center located in Chicago, ...
(Date:11/25/2015)... ... November 25, 2015 , ... In ... nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for pulmonary hypertension ... Pioneers, nominated by the public, will receive special recognition throughout 2016 as part ...
(Date:11/25/2015)... ... 25, 2015 , ... Many people know of the common symptoms of low ... dry skin. But many people who find their cholesterol levels and weight are creeping ... thyroid, especially if they don’t have any of the other symptoms. , Thyroid hormone ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bunion ... in an early celebration of the early holiday shopping season. Starting Wednesday November ... (normally $33.95 ea). Black Friday promotional pricing is in addition to any automatic ...
(Date:11/24/2015)... ... ... New patients who wish to seek treatment for missing teeth can now ... Mississauga, ON practice. Dr. Williams has been providing dental service for over 34 years, ... teeth can lead to a variety of complications if they are not replaced quickly, ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 2015  Thanks to a donor with a personal ... Center,s Sister Diane Grassilli Center for Women,s Health now ... San Francisco . Fred ... with a gift of $617,320 that allowed the Center ... Tomosynthesis and Whole Breast Ultrasound. Tomosynthesis, three-dimensional (3-D) mammography ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" ... announced today that the first patient has been enrolled ... a treatment for metastatic castration-resistant prostate cancer ("mCRPC"). ... --> the United States ... Phase 1/2 clinical trial, ESSA intends to demonstrate the ...
(Date:11/24/2015)... PUNE, India , November 24, 2015 ... new market research report "Spine Biologics Market by Product Type ... Type (Anterior Cervical Discectomy and Fusion, Posterior Lumbar Interbody Fusion), ... by MarketsandMarkets, the global market was valued at $1.90 Billion ... 2020, at a CAGR of 4.4% during the forecast period ...
Breaking Medicine Technology: