Navigation Links
Testosterone Therapy May Help Men With Heart Failure
Date:8/24/2009

Injections of male hormone boosted cardiac performance in Italian study

MONDAY, Aug. 24 (HealthDay News) -- Injections of the male hormone testosterone increased blood-pumping ability and heart muscle strength in men with heart failure, Italian researchers report.

"From our study, it appears that testosterone supplementation is useful for both patients with low and normal testosterone levels, although the improvements are greater in those with low levels," said Dr. Ferdinando Iellamo, an assistant professor of internal medicine at the University of Rome Tor Vergata, and lead author of a report in the Sept. 1 issue of the Journal of the American College of Cardiology.

Use of testosterone for heart failure, the progressive loss of the ability to pump blood throughout the body, has been controversial in some cases. About one of every four men with chronic heart failure has evidence of testosterone deficiency, as production of the hormone declines with age. Few studies of testosterone therapy in heart failure have been done in the United States, but several have been reported in Europe.

The Italian study included 70 elderly men with heart failure, all of whom had low testosterone levels. All received standard heart failure therapy, but half also received injections of 1,000 milligrams of long-acting testosterone at the start, and again at six and 12 weeks. A series of examinations -- electrocardiograms, exercise tests and assessments of muscle strength -- showed improvements in the men who received the hormone treatment but not in those who didn't.

It's not possible to specify the timing and dosage of testosterone therapy for men with heart failure, Iellamo said.

"There is no current guideline," he said. "However, our study indicates that long-acting testosterone at the dose and intervals we employed [to date used only in patients with hypogonadism] is safe and well-tolerated in patients with heart failure."

The study was not designed to determine whether testosterone therapy would prolong survival of men with heart failure, Iellamo said. "Future large trials are needed to appropriately evaluate the outcome," he said.

Such a multi-center trial is in the early planning stage, Iellamo noted. Meanwhile, his group is studying the effects of testosterone therapy in women. "Preliminary results seem promising," he added.

Men with heart failure who are tempted to try testosterone therapy on their own should avoid the temptation, he said. "It is absolutely contraindicated that patients choose testosterone, as well as all drugs, on their own," Iellamo said. The warning is especially important for men with high levels of prostate-specific antigen, an indicator of prostate cancer risk, he noted.

"This study confirms our previous finding for a beneficial effect of testosterone in men with moderate chronic heart failure, improving functional exercise capacity and insulin resistance," said Dr. T. Hugh Jones, a consultant endocrinologist at the University of Sheffield in England.

Jones and his colleagues have reported two studies with positive results, one using testosterone injections, the other using a hormone-delivering skin patch.

"Historically, testosterone-replacement therapy has been contraindicated in men with chronic heart failure," Jones said. "This was due to the fluid retention observed with older forms of testosterone preparation. This study, along with our studies, show that testosterone is safe in these patients and has a benefit on the underlying condition."

But the case for testosterone therapy in heart failure is far from proven, he said. "Now, longer-term studies evaluating effects on survival, quality of life and longer-term safety need to be done to establish if this treatment should be used routinely in the treatment of heart failure in men," Jones said.

More information

Heart failure and its treatment are described by the U.S. National Library of Medicine.



SOURCES: Ferdinando Iellamo, M.D., assistant professor, internal medicine, University of Rome Tor Vergata; T. Hugh Jones, M.D., consultant endocrinologist, University of Sheffield, England; Sept. 1, 2009, Journal of the American College of Cardiology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Risky Business: New Study Explores Role of Gender, Testosterone in Financial Risk Aversion
2. Blood-Sugar Spikes Send Testosterone Levels Down
3. Men with Low Testosterone See Multiple Doctors Before Being Diagnosed; Many Dissatisfied with Current Treatment Options
4. FDA Orders Label Warning for Testosterone Gels
5. Testosterone Injections Offer Hope for Male Contraceptive
6. Injectable testosterone may provide effective male contraception
7. Testosterone Undecanoate Achieves and Maintains Normal Testosterone Levels in Hypogonadal Men With Five Injections Per Year, New Data Show
8. Male Hormone Replacement Company Renewman.com Critical of MLB for Testosterone Abuse Publicity
9. Womens Testosterone Patch May Not Work
10. Prostate cancer drug reduces testosterone levels in as little as 3 days
11. Study shows testosterone improves sexual well-being in post-menopausal women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Testosterone Therapy May Help Men With Heart Failure
(Date:5/3/2016)... ... May 04, 2016 , ... Safety ... global construction firms representing the Construction Industry Safety Initiative (CISI) and the Incident ... purpose: to inspire everyone in the industry to be leaders in safety. Statistics ...
(Date:5/3/2016)... ... May 04, 2016 , ... The National Association ... into its VIP Woman of the Year Circle. She is recognized with this prestigious ... professional women, boasting more than 850,000 members and over 200 operating Local Chapters. , ...
(Date:5/3/2016)... ... May 03, 2016 , ... According to an article ... issues related to medical care in the hospital setting, which include excessive wait ... hospital staff. Commenting on this article, the founder of House Call Doctor Los ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... 2016 Champion Award to Charles D. Pulido, R.Ph., Co-Founder of NCPDP and member ... Ph.D., Pharmacy Advisor and Health IT Specialist, Office of the National Coordinator for ...
(Date:5/3/2016)... Redondo Beach, CA (PRWEB) , ... May 03, 2016 , ... ... together online to help cancer patients and their families move toward recovery and is ... the focus of today's Dr. Carol Francis Talk Radio show considering medical ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... YORK , May 2, 2016 Kalorama ... EMR (Electronic Medical Records) market in a recent white ... sales, vendor switches, Increased physician usage, a growing market are ... were noted in Kalorama,s report EMR 2016: ... report marks Kalorama,s seventh complete study of the EMR ...
(Date:5/2/2016)... NEW YORK , May 2, 2016 /PRNewswire/ ... Series B financing of Graybug Vision, Inc. Graybug ... to developing therapies that may transform care for ... and glaucoma.  Graybug Vision,s technology was first developed ... out into a startup venture. ...
(Date:5/2/2016)... LAWRENCEVILLE, N.J. , May 2, 2016 /PRNewswire/ ... drug development company, today announced data from the ... dose escalating clinical trial (the OVATION Study) combining ... of care for the treatment of newly-diagnosed patients ... chemotherapy followed by interval debulking surgery.  In the ...
Breaking Medicine Technology: