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Testing pain killers on humans could save money and speed the arrival of new drugs
Date:11/8/2012

del should be predictive for the particular clinical setting," says Ltsch, who works in the Institute of Clinical Pharmacology at the Goethe-University.

They found that overall, human experimental pain models were able to predict how well a drug worked in patients better than previously realised. "Not using these pain models in drug development seems to be unjustified in fact they should be used routinely in drug development programmes," says Oertel, who works in the Fraunhofer Project Group for Translational Medicine and Pharmacology (TMP), an initiative supported by the Hessian Excellence Initiative ("LOEWE") that runs at the junction between pharmacological research in academia and in the pharmaceutical industry.

The process isn't simple though as not every model can predict every clinical setting. "However, by analysing the way that drugs work in experimental and clinical settings, we identified that different sets of experimental pain models, rather than single models, may be best suited to provide cost-effective yet predictive studies in analgesic drug development," says Ltsch.

"It is difficult and unusual to undertake truly translational research in pharmacology. Here, Jrn Ltsch and Bruno G. Oertel have focused on experiments on humans to bridge the gap between animal research and clinical pharmacology. The review examines how well clinical analgesia is predicted by human experimental pain models, with a view to guiding model selection in phase I studies. The authors identify important disparities between drug effects on experimental and clinical pain. This will help inform thinking on the refinement of human and animal models of pain, ultimately helping the pharmaceutical industry bridge the translational gap in the pain field," says Editor-in-Chief of the British Journal of Pharmacology, Professor Ian McGrath.

More work is needed before this approach is fully ready to use, but the researchers believe this could l
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Contact: Ben Norman
Sciencenewsroom@wiley.com
44-012-437-70375
Wiley
Source:Eurekalert

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