Navigation Links
Test of maturity for stem cells
Date:5/6/2008

This release is available in German.

Stem cells are extremely versatile: They can develop in 220 different ways, transforming themselves into a correspondingly diverse range of specialized body cells. Biologists and medical scientists plan to make use of this differentiation ability to selectively harvest cardiac, skin or nerve cells for the treatment of different diseases. However, the stem cell culture techniques practiced today are not very efficient. What proportion of a mass of stem cells is transformed into which body cells" And in what conditions" We need devices that keep doing the same thing and thus deliver statistically reliable data, says Professor Gnter Fuhr, director of the Fraunhofer Institute for Biomedical Engineering IBMT in St. Ingbert.

Two prototypes of laboratory devices for stem cell differentiation enable the complex careers of stem cells to be systematically examined for the first time ever. These devices are the result of the international project CellPROM Cell Programming by Nanoscaled Devices which was funded by the European Union to the tune of 16.7 million euros and coordinated by the IBMT. The type of cell culture used until now is too far removed from the natural situation, says CellPROM project coordinator Daniel Schmitt for in the body, the stem cells come into contact with solute nutrients, messenger RNAs and a large number of different cells. Millions of proteins rest in or on the cell membranes and excite the stem cells to transform themselves into specialized cells. We want to provide the stem cells in the laboratory with a surface that is as similar as possible to the cell membranes, explains Daniel Schmitt. To this end, the consortium developed a variety of methods by which different biomolecules can be efficiently applied to cell-compatible surfaces.

In the two machines MagnaLab and NazcaLab the stem cells are brought into contact with the signal factors in a pre-defined manner. In MagnaLab, several hundred cells grow on culture substrates that are coated with biomolecules. In NazcaLab, large numbers of individual cells, washed around by a nutrient solution, float along parallel channels where they encounter micro-particles that are charged with signal factors. We use a microscope and a camera to document in fast motion how individual cells divide and differentiate, says Schmitt. The researchers demonstrated on about 20 different cell models that the multi-talents can be stimulated by surface signals to transform themselves into specialized cells.


'/>"/>

Contact: Daniel Schmitt
daniel.schmitt@ibmt.fraunhofer.de
49-689-498-0120
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related medicine news :

1. Researchers aim to prevent global prematurity and stillbirths
2. Researchers Aim to Prevent Global Prematurity and Stillbirths
3. Ohio Prematurity Caucus Forming to Meet Challenge
4. EGFR protects cancer cells from starvation via a kinase-independent mechanism
5. Unexpected role: EGFR protects cancer cells from starving
6. Mothers and Offspring Can Share Cells Throughout Life
7. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
8. Destruct triggers may be jammed in tumor cells, UF geneticists say
9. Mouse Adult Stem Cells Developed into Heart and Blood Cells
10. Specialized white blood cells coordinate first responders to viral infection
11. Embryonic Stem Cells Turned Into Three Types of Heart Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Test of maturity for stem cells
(Date:3/24/2017)... ... March 24, 2017 , ... ... at the same time by providing Prehospital Trauma Life Support (PHTLS) course scholarships ... world’s premier prehospital trauma education developed in cooperation with the American College of ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... from third world countries to hospitals in the United States, it’s a threat ... on the current obstacles facing infection prevention and offers strategies for the healthcare ...
(Date:3/24/2017)... , ... March 24, 2017 , ... The Radiology ... Quest Awards . The annual awards, now in their 12th year, are among the ... the winners. , In 2016, the awards were retooled to recognize achievements in both ...
(Date:3/24/2017)... ... March 24, 2017 , ... Texas Physical Therapy Specialists (TexPTS) ... found at 9618 Huebner Road. The clinic is the group’s 7th location in San ... Dr. Ali Higgins, PT, will provide care from the clinic, which opened March 22, ...
(Date:3/24/2017)... MI (PRWEB) , ... March 24, 2017 , ... ... assistance, financial planning, and related services to families and business owners across eastern ... aimed at feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... The global wound care market was worth $24,482.9 ... of 6.7% during 2016-2022 Among the various wound care products ... the global market in 2015. Among the various applications, surgical wound segment ...
(Date:3/24/2017)... March 24, 2017   The Accreditation Council ... medical affairs in the pharmaceutical industry has appointed ... of a newly formed scientific advisory board. Dr. ... form the first ever medical affairs think tank ... information about the ACMA, please visit  www.medicalaffairsspecialist.org .  ...
(Date:3/24/2017)... YORK , March 24, 2017 FinancialBuzz.com News ... Medical cannabis products ... View Research, Inc., projects that the global medical cannabis market will reach ... is a major market for the new growing industry. By ... place to legally buy and sell medical cannabis. More conservative states like ...
Breaking Medicine Technology: