Navigation Links
Test gives insight into prognosis in patients with plasma cell malignancies, finds Mayo Clinic study
Date:10/24/2007

ROCHESTER, Minn. -- A new Mayo Clinic study due to be presented at the annual meeting of the American Society of Human Genetics in San Diego this week shows that a chromosome test called FISH is better than conventional methods in identifying chromosomal genetic abnormalities associated with plasma cell malignancies. This improved chromosomal analysis may help physicians better assess a patients prognosis and likelihood to respond to a given treatment.

Plasma cell proliferative disorders, or PCPD, account for approximately 10 percent of all blood born cancers that range from the very slow-growing smoldering myeloma to a very aggressive plasma cell leukemia.

The study will be presented by Ryan Knudson of the Mayo Clinic Cytogenetics Laboratory at 6:30 p.m., CDT, Wednesday, Oct. 24.

FISH, which stands for fluorescence in situ hybridization, detected chromosomal abnormalities in 67 percent of 1,548 patients with suspected PCPD. Conventional chromosomal analysis detected abnormalities in only 10 percent of the same patients. The FISH test is designed to detect genetic abnormalities in plasma cells whereas other conventional methods typically looks within any cell type that is present, says the lead author of the study, Rhett Ketterling, M.D., a Mayo Clinic pathologist and geneticist who specializes in chromosomes and chromosomal abnormalities.

This test is a marked improvement over conventional chromosomal analysis and has become readily accepted into the diagnostic algorithm in patients with PCPD at Mayo Clinic and at other leading academic institutions, Dr. Ketterling says.

The test should be applied to patients diagnosed with PCPD, particularly multiple myeloma, to determine the presence of genetic abnormalities that could offer insight into prognosis, he states.

Our results show that a targeted plasma-cell specific FISH analysis is an important method for detecting common genetic abnormalities typically se
'/>"/>

Contact: Amy Reyes
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. WHO Gives Its Approval For Bird Flu Test Kit
2. Microchip gives blind a chance of sight
3. Microchip gives blind a chance of sight
4. Combined scan gives exact cancer diagnosis
5. Tennis gives protection against heart disease lifelong
6. Camera gives hope for detection of breast cancer
7. Pancreas transplant gives hope to type 2 diabetes
8. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
9. Gene Therapy Gives Hope For Patients With Muscular Dystrophy
10. FDA gives “black box warning” against three asthma drus
11. Statins Gives New Hope for Increased Survival Rate of Heart Failure Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... March 31, 2015 Effective April, 1 ... be moving his practice with North Texas Obstetrics & ... pursue his progressive approach to women’s healthcare. With 17 ... Dr. Eisenberg ensures this move will not interrupt the ... resources to open his practice to new patients. , ...
(Date:3/31/2015)... If you or someone you love ... from Irritable Bowel Syndrome (IBS), you will want to ... Lifetime Television® at 7:30am EDT/PDT on either Wednesday, April ... an informative health segment featuring interviews with Board Certified ... MD and Medical Scientist Victoria Jaison, PhD. To learn ...
(Date:3/31/2015)... March 31, 2015 First Choice ... emergency rooms in the United States, announced that it ... , “I am pleased to announce that we are ... in Haslet,” said Dr. James M. Muzzarelli, Executive Medical ... Choice Emergency Room is revolutionizing the delivery of emergency ...
(Date:3/31/2015)... With nationwide predictions of major floods due ... the pineapple express, the OPP is urging its insureds ... FEMA , "Protecting Your Business" 09/23/2014, provides alarming statistics ... your business. , Here are 3 statistics that every ... of small businesses never reopen their doors after a ...
(Date:3/30/2015)... Fl (PRWEB) March 31, 2015 AlignLife ... Hamtaee has recently opened his AlignLife clinic. As part ... offering of chiropractic, rehabilitation and nutritional consulting for all ... AlignLife is based on the expertise and compassion of ... pass a rigorous evaluation process and an extensive training ...
Breaking Medicine News(10 mins):Health News:Plano OBGYN Dennis Eisenberg, MD Joins North Texas Obstetrics & Gynecology Associates in Plano, Texas 2Health News:EnteraGam® to Be Featured on The Balancing Act® Airing on Lifetime Television® 2Health News:EnteraGam® to Be Featured on The Balancing Act® Airing on Lifetime Television® 3Health News:EnteraGam® to Be Featured on The Balancing Act® Airing on Lifetime Television® 4Health News:First Choice Emergency Room to Open New Facility in Haslet, Texas 2Health News:3 Statistics Every Business Owner Should Know About Flood Waters and Flood Insurance, from the Optometric Protector Plan® 2
... Kirsten Vangsness, Nanny 911,s Nanny Stella, ,Notes From the Underbelly, star ... the industry,s most fun ... fundraiser, LOS ANGELES, March ... 5th from 1pm - 4pm at the Loews Santa,Monica Hotel. The event will ...
... WetFeet Co-founder and CEO Gary Alpert to Lead Company,s Partnership ... ... Caring.com is pleased to,announce the arrival of Gary Alpert ... be responsible for the company,s,partnership and content licensing programs., ...
... Md., March 26 An annual analysis,to help ... that need,quality improvement now includes important information such ... mental illness and the number,of specialist doctors., ... factors" - are part,of the 2007 State Snapshots ...
... Researchers Strive to Help Caregivers of Dementia Patients Through ... T ) today,announced a $49,993 grant to the ... funding will be used to examine a,computer-integrated system for ... million adults in the nation provide care to someone,suffering ...
... Over 700 Frontline Clinicians Committed to ... March 26 The American Headache ... Medicine (AOAAM), American,Society of Pain Educators ... (IMDHA), National Fibromyalgia Research,Association (NFRA), National ...
... Rally for the Concerns of General Dentists and Their ... General Dentistry,s,(AGD) second annual advocacy conference, A Great Dentist ... 60 AGD constituent,leaders and member general dentists from 30 ... applied these sophisticated skills to more,than 100 Congressional offices ...
Cached Medicine News:Health News:Celebrities From All Walks of Life Put Their Best Foot Forward for the Fourth Annual Open Toe Shoe Party 2Health News:Caring.com Adds Vice President of Business Development 2Health News:AHRQ's 2007 State Snapshots Provide Broader Portraits of State-By-State Health Care Performance 2Health News:AHRQ's 2007 State Snapshots Provide Broader Portraits of State-By-State Health Care Performance 3Health News:AT&T Announces Grant to Center on Aging-University of Miami Miller School of Medicine 2Health News:AT&T Announces Grant to Center on Aging-University of Miami Miller School of Medicine 3Health News:National Pain Organizations Converge at PAINWeek(TM) 2008 2Health News:National Pain Organizations Converge at PAINWeek(TM) 2008 3Health News:AGD Advocacy Conference Connects General Dentists with Congress 2
(Date:3/30/2015)... N.Y., March 30, 2015  Uroplasty, Inc. (NASDAQ: ... ) shareholders have voted at the special meeting ... the previously announced agreement and plan of merger ... pleased with the outcome of today,s special meetings, ... groups for approving the merger agreement," said ...
(Date:3/30/2015)... , March 30, 2015 Perrigo Company plc ... of "Quality Affordable Healthcare Products®," today announced that it ... N.V. ("Omega") in a cash and equity transaction valued ... €1.3 billion in debt. Sellers are Marc Coucke ... of Waterland.    "The combination ...
(Date:3/30/2015)... -- A team of Chinese and US scientists has ... that plays a critical role in thrombosis, or blood ... features, which challenge the conventional concepts of drug action ... door for future drug discovery. In a ... the researchers at Shanghai Institute of Materia Medica ...
Breaking Medicine Technology:Uroplasty and Vision-Sciences Shareholders Approve Merger Agreement 2Uroplasty and Vision-Sciences Shareholders Approve Merger Agreement 3Uroplasty and Vision-Sciences Shareholders Approve Merger Agreement 4Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 2Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 3Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 4Perrigo Company plc Completes Acquisition Of Omega Pharma Invest N.V., Creating A Top Five Global OTC Company 5New Molecular Structures Challenge Conventional Concepts of Drug Action at Receptors 2New Molecular Structures Challenge Conventional Concepts of Drug Action at Receptors 3New Molecular Structures Challenge Conventional Concepts of Drug Action at Receptors 4New Molecular Structures Challenge Conventional Concepts of Drug Action at Receptors 5New Molecular Structures Challenge Conventional Concepts of Drug Action at Receptors 6
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
Medicine Products: