Test for hormones in blood not reflective of hormones in breast tissue; breast c...(e breast lead to breast cancer Llanos s...),Health

Date:4/22/2009

e breast lead to breast cancer," Llanos says. The researchers asked 15 women who were undergoing breast reduction surgery to participate in the study, and then collected three samples of discarded tissue from each breast, as well as blood, and extensive epidemiological data.

They first assessed whether levels of these hormones were the same in each of the three tissue samples taken from the women, which represented different areas of the breast. "We found that the hormones were distributed in the same way across the breast, which is a good thing to know because it means that a tissue biopsy taken from one part of the breast will likely represent the breast as a whole," says Llanos.

They then tested the blood to see if levels of the hormones matched those found in the breast tissue, and found that leptin, adiponectin, and IGFBP-3 correlated, whereas IGF-1 did not. But even that may be misleading, Llanos says, because hormone levels may differ between a woman's two breasts. "Breast cancer usually develops in a single breast, so it is not clear that looking at these hormones in the blood is sufficient," she says.

"If we want to know what is occurring in the breast, then we have to go to the tissue itself," Llanos says. "Measuring blood would be more convenient, but our study shows that, alas, this may not be accurate."

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Contact: Karen Mallet km463@georgetown.edu 215-514-9751 Georgetown University Medical Center Source:Eurekalert

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