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Test May Predict Moms Who Will Deliver Prematurely
Date:7/21/2009

Analysis of amniotic and cervical fluids yields clues to early birth

TUESDAY, July 21 (HealthDay News) -- Testing for a panel of proteins in amniotic and cervical fluids might enable doctors to identify women who are in danger of giving birth prematurely.

No such test exists now. If perfected, such a tool could supplement a test now available that can determine which women face a lower risk of delivering early.

"It is a breakthrough since it will provide a high positive predictive value," said Dr. Bo Jacobsson, who is with the perinatal center at Sahlgrenska University Hospital in Gothenburg, Sweden, and senior author of a study on the test. But its effectiveness will need confirming in a prospective study, he added.

The study is reported in the August issue of Obstetrics & Gynecology.

"It's very exciting. There's no question this could be very helpful, but the problem is these are really preliminary findings," said Dr. Marjorie Greenfield, associate professor of obstetrics and gynecology at Case School of Medicine and University Hospitals in Cleveland. "The test doesn't exist. It's in a research lab only. It's not clinically available."

Babies born prematurely often suffer significant medical problems, including breathing difficulties as a result of incompletely developed lungs. In the United States and other countries, the incidence of preterm delivery is increasing and now stands at about 12.5 percent, although the upward trend may be skewed by a higher number of multiple births, said Dr. Michael Cabbad, chairman of obstetrics and gynecology and chief of maternal/fetal medicine at the Brooklyn Hospital Center in New York City.

Doctors now use imperfect clinical measures, such as cervix length, to predict when a birth will occur.

For the study, the researchers took samples of amniotic and cervical fluids from 89 women in preterm labor. They then analyzed 37 p
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