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Temple scientists receive $11.5 million grant for heart failure research
Date:5/22/2014

so initiate repair mechanisms based on G protein and GRK regulation. As a result, the activity of AVP receptors, as well as GRK5 and TRP channels, which are turned on by G proteins, could be influenced therapeutically to favor cellular repair in the failing heart.

The new round of PPG funding comes at a key time. The number of Americans who suffer from heart failure is expected to increase from five million to ten million by 2031. That increase will be accompanied by a significant rise in deaths from the condition, if new therapies are not developed soon.

Temple is a key site for the origination of those much-needed treatments. When the first PPG was awarded, Drs. Feldman and Koch were based at Thomas Jefferson University, located a few miles from Dr. Houser's laboratory at Temple. Now, all three scientists are in the same building, Drs. Feldman and Koch having relocated to Temple. The proximity of the research teams allows for an unprecedented level of interaction in heart failure research at Temple's Center for Translational Medicine and Cardiovascular Research Center.

"The PPG is of great importance to Temple," explained Dr. Feldman. "It provides not only funding for specific projects but also supports state-of-the-art core facilities and a platform for team science, both of which are critical to success in this era of translational science."


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Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
215-707-7882
Temple University Health System
Source:Eurekalert

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