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Temple researchers show targeted cancer drug may stunt heart's ability to repair itself
Date:11/6/2012

subsequently treated bone marrow stem cells, heart stem cells, and heart muscle cells (myocytes) with sorafenib in the laboratory dish. The drug blocked both types of stem cells from growing, but had no effect on normal heart muscle cells. This meant that the drug likely doesn't affect normal heart cells that were not damaged and under repair, Dr. Houser pointed out. "Injury activates the proliferation of the stem cells," he said. "We think it's something about the repair process that the drug affects."

He and his team would like to find drugs that could be taken alongside cancer drugs such as sorafenib that would reduce adverse effects on heart stem cells. At this time, they are developing a program to screen candidate agents. "Ideally, we could help physicians predict which patients are at higher risk for these effects, and find better ways to screen patients," Dr. Houser said.

The investigators next plan to test therapies to stimulate repair and protect hearts from potential damage from such cancer drugs.


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Contact: Steven Benowitz
steven.benowitz@tuhs.temple.edu
215-707-4784
Temple University Health System
Source:Eurekalert

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