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Temperature-sensing protein linked to skin cancer, hirsutism
Date:4/15/2010

nships among the three proteins. Their experiments revealed a chain of steps in which activation of TRPV3 leads to release of TGF-alpha, which activates EGFR. Activation of EGFR then feeds back to increase TRPV3 channel activity, forming a positive signaling loop.

Finding that the three proteins all work in concert is important, given the roles that TGF-alpha and EGFR play in skin diseases and abnormal hair growth, said Xu. "Many current anti-cancer drugs target EGFR, and our identification of TRPV3 as an essential regulator of EGFR places TRPV3 as a new drug target for cancer and other skin disorders. The additional connection to hair growth could also make TRPV3 useful in controlling that process."


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Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

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