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Temperature-sensing protein linked to skin cancer, hirsutism
Date:4/15/2010

ANN ARBOR, Mich.---New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers.

The common denominator that unites these seemingly unrelated processes is a versatile protein called TRPV3. The new research shows that in addition to serving as a temperature sensor, the protein is important for proper hair growth and skin health. The work, by University of Michigan cell biologist Haoxing Xu and colleagues, is described in a paper published in the April 16 issue of the journal Cell.

Found mainly in cells called keratinocytes in the outer layer of skin, TRPV3 functions as a calcium channel---a gateway that, when activated, allows calcium to pass through and deliver signals that stimulate processes such as muscle contraction, release of hormones or firing of neurons.

Some years ago, Xu identified TRPV3 and found that it is activated by warm temperatures and certain spices such as oregano. "Those are its sensory functions, but I wanted to know if it also plays a role in the basic biology of keratinocytes," said Xu. To get at that question, Xu's team created "knockout" mice, which lacked TRPV3.

The TRPV3-deficient mice had peculiar, wavy hair, and the outermost layer of their skin, which normally forms a barrier against germs and poisonous substances, was thinner than it should be. This was interesting, because the same two abnormalities, wavy hair and a thin epidermal barrier, are known to occur in mice with particular mutations. One such mutation affects a growth factor called TGF-alpha; the other affects a cell-surface receptor called EGFR, which is activated by TGF-alpha. Conversely, when TGF-alpha and EGFR are overactive, hairlessness and skin disorders, including skin cancer, may result.

The fact that the loss of TRPV3 produced the same effects as abnormalities in TGF-alpha and EGFR made Xu and colleagues curious about relatio
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Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

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