Navigation Links
Temperature-sensing protein linked to skin cancer, hirsutism
Date:4/15/2010

ANN ARBOR, Mich.---New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers.

The common denominator that unites these seemingly unrelated processes is a versatile protein called TRPV3. The new research shows that in addition to serving as a temperature sensor, the protein is important for proper hair growth and skin health. The work, by University of Michigan cell biologist Haoxing Xu and colleagues, is described in a paper published in the April 16 issue of the journal Cell.

Found mainly in cells called keratinocytes in the outer layer of skin, TRPV3 functions as a calcium channel---a gateway that, when activated, allows calcium to pass through and deliver signals that stimulate processes such as muscle contraction, release of hormones or firing of neurons.

Some years ago, Xu identified TRPV3 and found that it is activated by warm temperatures and certain spices such as oregano. "Those are its sensory functions, but I wanted to know if it also plays a role in the basic biology of keratinocytes," said Xu. To get at that question, Xu's team created "knockout" mice, which lacked TRPV3.

The TRPV3-deficient mice had peculiar, wavy hair, and the outermost layer of their skin, which normally forms a barrier against germs and poisonous substances, was thinner than it should be. This was interesting, because the same two abnormalities, wavy hair and a thin epidermal barrier, are known to occur in mice with particular mutations. One such mutation affects a growth factor called TGF-alpha; the other affects a cell-surface receptor called EGFR, which is activated by TGF-alpha. Conversely, when TGF-alpha and EGFR are overactive, hairlessness and skin disorders, including skin cancer, may result.

The fact that the loss of TRPV3 produced the same effects as abnormalities in TGF-alpha and EGFR made Xu and colleagues curious about relationships among the three proteins. Their experiments revealed a chain of steps in which activation of TRPV3 leads to release of TGF-alpha, which activates EGFR. Activation of EGFR then feeds back to increase TRPV3 channel activity, forming a positive signaling loop.

Finding that the three proteins all work in concert is important, given the roles that TGF-alpha and EGFR play in skin diseases and abnormal hair growth, said Xu. "Many current anti-cancer drugs target EGFR, and our identification of TRPV3 as an essential regulator of EGFR places TRPV3 as a new drug target for cancer and other skin disorders. The additional connection to hair growth could also make TRPV3 useful in controlling that process."


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Related medicine news :

1. Protein May Help Control Weight
2. The assembly of protein strands into fibrils
3. Leukemia-related protein 16 and colorectal carcinoma
4. Caltech scientists uncover structure of key protein in common HIV subgroup
5. UD team develops new method for producing proteins critical to medical research
6. Proteins in unroasted coffee beans may become next-generation insecticides
7. Protein in Breast Tumors May Predict Chemo Response
8. Tumors Use a Protein to Hide From Immune System
9. Newly identified proteins critical to FA pathway DNA repair function
10. Proteins may point to alcohol use test
11. Blocking Protein May Stem COPD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
Breaking Medicine Technology: