Navigation Links
Temperature-sensing protein linked to skin cancer, hirsutism
Date:4/15/2010

ANN ARBOR, Mich.---New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers.

The common denominator that unites these seemingly unrelated processes is a versatile protein called TRPV3. The new research shows that in addition to serving as a temperature sensor, the protein is important for proper hair growth and skin health. The work, by University of Michigan cell biologist Haoxing Xu and colleagues, is described in a paper published in the April 16 issue of the journal Cell.

Found mainly in cells called keratinocytes in the outer layer of skin, TRPV3 functions as a calcium channel---a gateway that, when activated, allows calcium to pass through and deliver signals that stimulate processes such as muscle contraction, release of hormones or firing of neurons.

Some years ago, Xu identified TRPV3 and found that it is activated by warm temperatures and certain spices such as oregano. "Those are its sensory functions, but I wanted to know if it also plays a role in the basic biology of keratinocytes," said Xu. To get at that question, Xu's team created "knockout" mice, which lacked TRPV3.

The TRPV3-deficient mice had peculiar, wavy hair, and the outermost layer of their skin, which normally forms a barrier against germs and poisonous substances, was thinner than it should be. This was interesting, because the same two abnormalities, wavy hair and a thin epidermal barrier, are known to occur in mice with particular mutations. One such mutation affects a growth factor called TGF-alpha; the other affects a cell-surface receptor called EGFR, which is activated by TGF-alpha. Conversely, when TGF-alpha and EGFR are overactive, hairlessness and skin disorders, including skin cancer, may result.

The fact that the loss of TRPV3 produced the same effects as abnormalities in TGF-alpha and EGFR made Xu and colleagues curious about relationships among the three proteins. Their experiments revealed a chain of steps in which activation of TRPV3 leads to release of TGF-alpha, which activates EGFR. Activation of EGFR then feeds back to increase TRPV3 channel activity, forming a positive signaling loop.

Finding that the three proteins all work in concert is important, given the roles that TGF-alpha and EGFR play in skin diseases and abnormal hair growth, said Xu. "Many current anti-cancer drugs target EGFR, and our identification of TRPV3 as an essential regulator of EGFR places TRPV3 as a new drug target for cancer and other skin disorders. The additional connection to hair growth could also make TRPV3 useful in controlling that process."


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Related medicine news :

1. Protein May Help Control Weight
2. The assembly of protein strands into fibrils
3. Leukemia-related protein 16 and colorectal carcinoma
4. Caltech scientists uncover structure of key protein in common HIV subgroup
5. UD team develops new method for producing proteins critical to medical research
6. Proteins in unroasted coffee beans may become next-generation insecticides
7. Protein in Breast Tumors May Predict Chemo Response
8. Tumors Use a Protein to Hide From Immune System
9. Newly identified proteins critical to FA pathway DNA repair function
10. Proteins may point to alcohol use test
11. Blocking Protein May Stem COPD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2017)... ... ... Can't Win Them All”: the story of an entrepreneur and a family man whose ... lives of young athletes. “You Can't Win Them All” is the creation of ... small town in Northern Ontario, Canada. He is an entrepreneur who manages to ...
(Date:9/22/2017)... ... 22, 2017 , ... PITTSBURGH...Defibrillators are used to treat a ... one isn’t accessible in certain locations, the risk of death can be very ... this idea," said an inventor from Ridgecrest, Calif. , The MOBILE AUTOMATED EXTERNAL ...
(Date:9/22/2017)... ... ... After a long health ordeal that involved a number ... with assistance from CreditAssociates. CreditAssociates provides debt relief and debt settlement programs that ... is one of the satisfied clients who expressed their appreciation for the excellent ...
(Date:9/22/2017)... California (PRWEB) , ... September 22, 2017 , ... Happy ... at a time - carries it into the entertaining and delicious worlds of ... Matt Gersper (founder of Happy Living) convinced him to turn his play into a ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... a nutritional supplement produced by Native Remedies that helps promote pancreatic health and ... for many individuals. However, some prescription-based approaches can have negative side effects, and ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
(Date:9/9/2017)... ... to Washington DC ... September 12 th – Monday, September 18 th .The Brain Tumor ... brain scans to the public.Where:  BTF,s Mobile MRI ... K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road to ...
Breaking Medicine Technology: