Navigation Links
Telomere length influences cancer cell differentiation
Date:6/27/2013

Researchers from the Japanese Foundation for Cancer Research in Tokyo have discovered that forced elongation of telomeres (extensions on the end of chromosomes) promotes the differentiation of cancer cells, probably reducing malignancy, which is strongly associated with a loss of cell differentiation. They report their findings in a manuscript published online ahead of print, in the journal Molecular and Cellular Biology.

"Cancer cells may maintain short telomeres to maintain their undifferentiated state," says Hiroyuki Seimiya, a researcher on the study.

Telomeres are protective extensions on the ends of chromosomes, which shorten as cells age, like an hourglass running down. They protect the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Without telomeres chromosomes would progressively lose genetic information as cells divide and replicate.

Cancer cells have shorter telomeres compared to healthy cells, but they guard their immortality by maintaining these telomeres' length.

In the study, the forced elongation of cancer cells' telomeres suppressed a number of genes and proteins that appear to be involved in tumor malignancy, according to the report. For example, one of these factors, N-cadherin, is involved in prostate cancer metastasis.

Based on their results, the investigators now propose that telomeres also modulate the behavior of cells by controlling gene expression, by as yet unknown mechanisms, says Seimiya. His research, he says, may ultimately lead to new types of treatments for cancer.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. DNA Telomere Length Tied to Aging, Death Risk
2. Lengthy Seizures May Delay Mental Development, Study Suggests
3. Jacksonville Periodontist, Dr. Richard E. Aguila, Now Fixes High Gum Lines with Crown Lengthening Procedures for His Florida Patients with Excessive Gums Showing
4. Marriage Might Lengthen Life
5. Oxytocin keeps flirting folks at arms length
6. 24-hour ICU in-house staff intensivist improves mortality and decreases length of stay
7. Low-Cal Diets Kept Monkeys Healthier, But Didnt Lengthen Lives
8. Acai counteracts oxidative stress, lengthens lifespan in fruit flies
9. Study: Vaccine targets malignant brain cancer antigens, significantly lengthens survival
10. Is arm length the reason women need reading glasses sooner than men?
11. Former Athlete Credits Sports for Surviving Horrible Car Accident and Lengthy Coma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... PA (PRWEB) October 22, 2014 Richard ... as an industry leader with over 25 years experience. ... team leader in the areas related to EDI, B2B ... Carlson is an Editorial Advisory Board member for Pharmaceutical ... Educator. Blue Fin Group is a management and ...
(Date:10/22/2014)... News) -- Two sisters in high school have developed ... and Medha Krishen use electronic stethoscopes, which electronically amplify ... breathing patterns or heartbeats. Ilina, a senior at ... find a way to detect early lung damage in ... stethoscope, Ilina recorded one breath cycle each from 16 ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, ... tightened guidelines for health workers treating Ebola patients, now requiring ... a respirator at all times. The U.S. Centers for ... after two Dallas nurses contracted Ebola while caring for the ... Thomas Eric Duncan. Nina Pham is currently being treated for ...
(Date:10/20/2014)... October 20, 2014 Allegheny General Hospital’s ... that enables physicians to repair a damaged mitral valve ... MitraClip system, developed by Abbott Vascular , ... progressive and life-threatening condition in which the heart’s mitral ... flow backward from the heart’s left ventricle into the ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 T.E.N., ... relationship-marketing firm, announced today that William H. Murray, ... the 2014 ISE® Luminary Leadership Award winner. Presented ... achievements of an outstanding leader and industry practitioner ... contributions in advancing the information security industry. , ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4
... (TSX: RBM, OTCBB: RPBIF) reported that it recorded ... $13,901,041 or ($0.12) per share,for the year ended ... of December 31, 2007 it had approximately $8.2 ... the Company,s financial results for,the year ended December ...
... China,Shenghuo Pharmaceutical Holdings, Inc. (Amex: KUN ) ... the research, development, manufacture,and marketing of pharmaceutical, nutritional ... China ("PRC"), today announced it will,conduct a conference ... 2, 2008, to,discuss the Company,s financial results for ...
... NMHC,s Stockholders Accept ... SXC,s ... -,SXC Health Solutions Corp. ("SXC") (Nasdaq: SXCI ; TSX: SXC) ... jointly announced,today that, pursuant to their previously announced merger agreement, SXC ...
... finds uncertainty about risks and benefits of mastectomies or ... half the women diagnosed with early-stage breast cancer clearly ... a breast-conserving lumpectomy plus radiation, even after they have ... , If the woman is black or Hispanic, the ...
... CNS Response,Inc. (OTC Bulletin Board: CNSO) ... roll out referenced-EEG(R) (rEEG(R)) availability with an,undisclosed, ... enables psychiatrists under the management of the ... to treat their most,therapy-challenged patients suffering any ...
... 31 LCA-Vision Inc. (Nasdaq:,LCAV), a leading provider ... announced the opening of its 76th LasikPlus(R) vision,center ... fourth,LasikPlus(R) vision center opened this year, and the ... opened a LasikPlus(R) vision,center in Paramus in April ...
Cached Medicine News:Health News:Response Biomedical Corporation Reports 2007 Financial Results 2Health News:Response Biomedical Corporation Reports 2007 Financial Results 3Health News:Response Biomedical Corporation Reports 2007 Financial Results 4Health News:Response Biomedical Corporation Reports 2007 Financial Results 5Health News:China Shenghuo Pharmaceutical Holdings, Inc. Schedules Conference Call to Discuss FY 2007 Results 2Health News:China Shenghuo Pharmaceutical Holdings, Inc. Schedules Conference Call to Discuss FY 2007 Results 3Health News:SXC Health Solutions Corp. Commences Exchange Offer For Shares Of National Medical Health Card Systems, Inc. 2Health News:SXC Health Solutions Corp. Commences Exchange Offer For Shares Of National Medical Health Card Systems, Inc. 3Health News:SXC Health Solutions Corp. Commences Exchange Offer For Shares Of National Medical Health Card Systems, Inc. 4Health News:SXC Health Solutions Corp. Commences Exchange Offer For Shares Of National Medical Health Card Systems, Inc. 5Health News:Many Women Unclear About Breast Cancer Treatments 2Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 2Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 3Health News:CNS Response, Inc. Enters Agreement to Introduce rEEG(R) Platform to Managed Behavioral Health Organization 4Health News:LCA-Vision Announces the Opening of its 76th LasikPlus(R) Vision Center in Woodbridge, New Jersey 2
(Date:10/22/2014)... NORWALK, Conn. , Oct. 22, 2014  Recently ... (GERD) have bolstered the already substantial database of evidence. ... and adoption of Stretta therapy for sufferers ... of clinical evidence supporting Stretta therapy as ... coverage policies that make Stretta therapy available to nearly ...
(Date:10/20/2014)... VIEW, California , 20 de octubre de ... líder en el campo de la pulmonología intervencional, ... su Estudio RENEW, casi 3 meses antes de ... fundamental de exención de dispositivo de investigación (IDE) ... Medicamentos) para el sistema de espiral de reducción ...
(Date:10/20/2014)... Valeritas, Inc., a leader in simple, disposable ... 2 diabetes, announced today that it has received a ... was presented October 16 th at Cardinal,s annual ... . The Cardinal Health Supply Chain ... metrics specifically targeted at the importance of developing collaborative ...
Breaking Medicine Technology:Recent Clinical Study Data Confirms Efficacy of Stretta Therapy - Spurs Additional Insurance Coverage and Financing Round 2PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 2Valeritas Receives 2014 Cardinal Health Supply Chain Excellence Award 3
... , MAPLE GROVE, Minn., Dec. 3 Upsher-Smith ... plan for central nervous system (CNS) diseases with USL255 (extended ... epilepsy. USL255 is being developed with Upsher-Smith,s proprietary formulation technology ... 2010 for the adjunctive treatment of epilepsy patients with partial ...
... , HARRISBURG, Pa., Dec. 3 ... processing company build a new cold storage facility and ... at least 20 jobs, Governor Edward G. Rendell announced ... more than $2.9 million for three projects. The investments, ...
Cached Medicine Technology:Upsher-Smith Announces Milestone in Development of CNS Strategy 2Governor Rendell: New State Investments Bear Fruit in Adams County; Help Pharmaceutical Company Expand in Philadelphia 2
... E-Gel® 96 and E-Gel® 48 ... E-Base™ electrophoresis bases, which combine the ... device. , The mother E-Base™ power ... can be connected directly to an ...
... Turn routine agarose gel electrophoresis into ... 96 system. This bufferless, pre-cast system is ... preparations, restriction digests, and more. Fully automated, ... the E-Gel 96 system makes your high-throughput ...
... System provides a compact format to rapidly ... PCR products and synthetic oligonucleotides, while using ... Horizontal Unit has gel bed dimensions of ... bed is UV transparent. Adjustable height Combs ...
... for very fast and clear separation of DNA restriction ... to cast, run, and perform Southern or Northern blotting ... electrophoresis tank and cover, 1 x Gel Maker Stand ... x MT-T02 (50 x 60 mm tray), 1 x ...
Medicine Products: