Navigation Links
Telomerase enzyme structure provides significant new target for anti-cancer therapies
Date:11/13/2007

(PHILADELPHIA) Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Since the mid-1990s, when telomerase was first identified in human tumors, scientists have eyed the enzyme as an ideal target for developing broadly effective anti-cancer drugs.

Now, researchers working at The Wistar Institute have brought this goal closer by deciphering the three-dimensional structure of a domain, or region, of the telomerase molecule essential for the activity of the enzyme. The findings, published November 13 in the journal Structure, may help scientists develop strategies to design the first direct inhibitors of telomerase.

Telomerase also has been shown to play a central role in normal aging, and the new study may shed light on that vital life process as well. The potential for creating new cancer treatments, however, is the most important immediate implication of the study.

Knowing the physical structure of this complex will give pharmaceutical companies a direct target for designing drugs that disrupt a mechanism that telomerase uses to assemble itself, says Emmanuel Skordalakes, Ph.D., an assistant professor in the Gene Expression and Regulation Program at Wistar and senior author on the study. Such drugs could well have significant anti-cancer activity.

Telomerase is essential for normal cell division and survival, and has been associated with aging and cancer. In humans, the usual role of telomerase is to add multiple repeats of a short length of DNA to the ends of chromosomes, known as telomeres, thus preventing damage and the loss of genetic information during DNA replication. It performs this critical service in developing embryos and in a few specialized cell lines, including stem cells.

In normal adult cells, however, telomerase is switched off almost entirely to prevent the dangers of runaway cell
'/>"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Elliott Extremely Dissatisfied With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company
3. Scientists reveal DNA-enzyme interaction with first ever real time footage
4. UCSD study reveals the regulatory mechanism of key enzyme
5. UCSD study reveals the regulatory mechanism of key enzyme
6. Enzymes second messenger contributes to cell overgrowth
7. Delaware Court Approves Bioenvision, Genzyme Joint Petition
8. Genzyme and Bayer Schering Pharma AG, Germany to Present New Data on Alemtuzumab in Multiple Sclerosis at ECTRIMS
9. Genzyme Statement Regarding Results of FDA Advisory Committee Meeting on the Use of Phosphate Binders in Chronic Kidney Disease
10. Bioenvision Shareholders Approve Acquisition by Genzyme Corporation
11. Role of a key enzyme in reducing heart disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... of bird flu had been discovered in a Farm in ... cull thousands more, South Korea’s Farm// Ministry officials said on ... Kim Chang-sub, a top official at the Ministry’s Quarantine department ... avian influenza.' Kim also added that the final results of ...
... a new vaccine that promises protection against a wide range ... using a cell-based technology in 11 weeks time.The vaccine is ... H5N1 virus. ,It is still in the early phase of ... been detected in many countries. It has caused maximum damage ...
... Group (World Against Toys Causing Harm), for the 34th time, ... title 'Most Dangerous Toys of 2006' to watch out for. ... James Swartz, an attorney and director of Boston-based WATCH, which ... toy shelves are potentially stocked with dangerous toys which may ...
... in childhood could face an increased risk of developing ... ,The traditional view has been that psychosis such ... most psychiatrists have believed that social factors cannot have ... new study by the Institute of Psychiatry here examined ...
... McKeith has been reprimanded by the Medicines and Healthcare Regulatory ... a license. The authority said there was a lack of ... the star of Channel 4’s You Are What You Eat, ... Formula Wild Pink for women and Fast Formula Horny for ...
... incident 2 years ago, four persons had to be hospitalized ... with an cosmetic product that was unlicensed. The injection contained ... the lethal dose for humans, reported by The Journal of ... toxin, botox, is used to smoothen out facial wrinkles by ...
Cached Medicine News:Health News:WATCH's 2006 List Of Ten Potentially - Dangerous Toys 2
(Date:12/15/2014)... 15, 2014   DaVita HealthCare Partners Inc. ... nation,s largest and most innovative health care communities, ... DaVita Clinical Research  (DCR) and  HealthCare Partners Clinical ... its extensive clinical research and data analytics services, ... and end-stage renal disease (ESRD), as well as ...
(Date:12/15/2014)... and BOSTON , December 15, ... GPCR structure-guided drug discovery and development company, is pleased ... the United States relating to ... patents in the US significantly strengthens the global patent ... pharmaceutical markets. The suite of patents recently ...
(Date:12/13/2014)... Research and Markets ( http://www.researchandmarkets.com/research/2r6bmg/drug_injection ... "Drug Injection Devices to 2020" report to ... As new drugs become available ... health conditions, drug developers have increasingly pursued packaging ... and increase the efficiency and reliability with which ...
Breaking Medicine Technology:DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4
... treating the diabetes patient, doctors discussed how a ... not enough to reveal an individual,s risk for ... Clinical Endocrinologists (AACE) 18th Annual Meeting & Clinical ... "We need to be more aggressive in treating ...
... Corporation (Nasdaq: BPUR ) announced ... U.S. Naval Medical Research Center (NMRC) by letter that it ... Hemopure(R) [hemoglobin glutamer -- 250 (bovine)] under a proposed protocol ... announced, the study, "Restore Effective Survival in Shock" (RESUS) was ...
Cached Medicine Technology:Taking a Hard-Line Approach to Cardiovascular Risks in the Diabetes Patient 2U.S. Naval Medical Research Center Proposed 'RESUS' Clinical Trial in Trauma Patients Remains on FDA Hold 2U.S. Naval Medical Research Center Proposed 'RESUS' Clinical Trial in Trauma Patients Remains on FDA Hold 3
... An external computer-enhanced microplate reader ... provides automated flexible and rapid ... for accurate and reliable photometric ... or without shaking before reading) ...
... a number of assay steps for ... simple to use benchtop device. The ... stand-alone device but also provides easy ... and standard add-on modules provide maximum ...
... AP-22 Micro Plate Processor is ... Automated Microplate Analyzer. It has been ... assigned area can be customised according ... Micro Plate Processor is able to ...
Grab one and go, One of the smallest handheld oximeters available, Datex-Ohmeda s TuffSat is the ideal spot-check solution for hospital, home care, transport, and EMS. TuffSat comes fully loaded wi...
Medicine Products: