Navigation Links
'Tell-tail' MRI image diagnosis for Parkinson's disease

An image similar in shape to a Swallow's tail has been identified as a new and accurate test for Parkinson's disease. The image, which depicts the healthy state of a group of cells in the sub-region of the human brain, was singled out using 3T MRI scanning technology standard equipment in clinical settings today.

The research was led by Dr Stefan Schwarz and Professor Dorothee Auer, experts in neuroradiology in the School of Medicine at The University of Nottingham and was carried out at the Queen's Medical Centre in collaboration with Dr Nin Bajaj, an expert in Movement Disorder Diseases at the Nottingham University Hospitals NHS Trust.

The findings have been published in the open access academic journal PLOS one.

The work builds on a successful collaboration with Professor Penny Gowland at the Sir Peter Mansfield Magnetic Resonance Centre at The University of Nottingham.

'The 'Swallow Tail' Appearance of the Healthy Nigrosome A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T' describes how the absence of this imaging sign can help to diagnose Parkinson's disease using standard clinical Magnetic Resonance Scanners.

Parkinson's disease is a progressive neurodegenerative disorder which destroys brain cells that control movement. Around 127,000 people in the UK have the disease. Currently there is no cure but drugs and treatments can be taken to manage the symptoms.

The challenges of diagnosing Parkinson's

Until now diagnosing Parkinson's in clinically uncertain cases has been limited to expensive nuclear medical techniques. The diagnosis can be challenging early in the course of the condition and in tremor dominant cases. Other non-licensed diagnostic techniques offer a varying range of accuracy, repeatability and reliability but none of them have demonstrated the required accuracy and ease of use to allow translation into standard clinical practice.

Using high resolution, ultra high filed 7T magnetic resonance imaging the Nottingham research team has already pinpointed the characteristic pathology of Parkinson's with structural change in a small area of the mid brain known as the substantia nigra. The latest study has shown that these changes can also be detected using 3T MRI technology which is accessible in hospitals across the country. They subsequently coined the phrase the 'swallow tail appearance' as an easy recognizable sign of the healthy appearing substantia nigra which is lost in Parkinson's disease. A total of 114 high-resolution scans were reviewed and in 94 per cent of cases the diagnosis was accurately made using this technique.

New findings give new hope

Dr Schwarz said: "This is a breakthrough finding as currently Parkinson's disease is mostly diagnosed by identifying symptoms like stiffness and tremor. Imaging tests to confirm the diagnosis are limited to expensive nuclear medical techniques which are not widely available and associated with potentially harmful ionizing radiation.

"Using Magnetic Resonance Imaging (no ionizing radiation involved and much cheaper than nuclear medical techniques) we identified a specific imaging feature which has great similarity to a tail of a swallow and therefore decided to call it the 'swallow tail sign'. This sign is absent in Parkinson's disease."


Contact: Lindsay Brooke
University of Nottingham

Related medicine news :

1. Computing the best high-resolution 3-D tissue images
2. Image share project gives patients and physicians anytime, anywhere access to medical images
3. Electronic medical record improves physician compliance of reviewing portal images, study suggests
4. Device converting images into music helps individuals without vision reach for objects in space
5. Research links sexual imagery and consumer impatience
6. U.S. Appeals Court Backs Ruling Against Graphic Images on Cigarette Packs
7. An open platform revolutionizes biomedical-image processing
8. Repeated exposure to traumatic images may be harmful to health
9. Gruesome Cigarette Pack Images Sway Smokers, Study Finds
10. New MRI technology to provide even better images of the inside of the human body
11. The image of mental fatigue
Post Your Comments:
Related Image:
'Tell-tail' MRI image diagnosis for Parkinson's disease
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has released a ... Mesothelioma has just posted the findings on the website. Click here to read ... of 136 mesothelioma patients who were treated with chemotherapy followed by EPP surgery. Among ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... 27th edition of USA Today in Atlanta, Dallas, New York, Minneapolis, South Florida, ... The digital component is distributed nationally, through a vast social media strategy and ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced ... User Group (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics ... software users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ...
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College ... Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD ... colleges, as only one of twelve colleges and universities in the state of California ...
(Date:11/27/2015)... ... 27, 2015 , ... Indosoft Inc., developer and distributor of ... 11 LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making ... with a version of Asterisk that will receive not only security fixes, but ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... A new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... has found that immunotherapy can be efficiently ...
(Date:11/26/2015)... 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in the ... Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new 247-page ... therapeutic drug monitoring market, including emerging tests, technologies, ...
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 Research ... of the "Advanced Wound Care Market by Type ... Ulcers), End User (In-Patient Facility, Out-Patient Facility), and Geography ... offering. --> --> ... the description, definition and forecast of the global advanced ...
Breaking Medicine Technology: