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Tel Aviv University scientists honored for proposals in melanoma research
Date:2/18/2014

e at the tumor site, the new nanomedicines can inhibit the cross-talk between the melanoma cells and the brain microenvironment. We hope that our novel approach for co-targeting melanoma cells and astrocytes will pave the road for new clinical interventions."

A disarmament proposal for tumor cells

The MRA granted its second Team Science Award of $450,000 to Dr. Gal Markel and his team Dr. Tamar Geiger of TAU's Sackler Faculty of Medicine's Department of Human Molecular Genetics and Biochemistry, and Dr. Noam Shomron, director of TAU's Sackler Faculty of Medicine's Functional Genomics Laboratory. The focus of their study is to discover the mechanisms that allow tumors to evade the immune system, then to disarm those mechanisms, making the tumor susceptible to the patient's own immune response.

"Immunotherapy, which has existed for decades, has had slim success rates in melanoma treatment. But now, after new insights and developments over the last 10 years, it has become a hot topic everyone is discussing," said Dr. Markel. "We are focused on the immunology of melanoma how the immune system reacts to melanoma cells, how melanoma evades the immune system, and defining key processes."

Dr. Markel's team is working directly with melanoma patients who are treated with immunotherapy. "We are taking advantage of our years of unique clinical work, bringing it to the bench for a cutting-edge multi-faceted discovery process," Dr. Markel says.

To date, the MRA, which is the largest private funder of melanoma research, has awarded more than $51 million worldwide to advance prevention, diagnosis, and treatment. Based in Washington, DC, the alliance's ultimate goal is to find a cure by funding the most promising melanoma research worldwide that will accelerate progress and improve outcomes for patients and all who are at risk.


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

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