Navigation Links
Tel Aviv University scientists honored for proposals in melanoma research
Date:2/18/2014

Tel Aviv University researchers won two out of three prestigious melanoma research awards granted this year by The Melanoma Research Alliance (MRA) and The Saban Family Foundation. The Team Science Awards are the centerpiece of the MRA research fund, which seeks to promote transformational melanoma research for swift clinical implementation.

Melanoma is the deadliest form of skin cancer. For their cross-disciplinary melanoma research proposals, two teams of TAU scientists and doctors received a total of $1.35 million. Leading the teams are Prof. Ronit Satchi-Fainaro of TAU's Sackler Faculty of Medicine's Department of Physiology and Pharmacology and head of TAU's Cancer Angiogenesis and Nanomedicine Laboratory; and Dr. Gal Markel, of TAU's Sackler Faculty of Medicine's Department of Microbiology and Clinical Immunology and head of the research laboratory at TAU's Ella Institute for the Treatment and Research of Melanoma and Skin Cancer at Sheba Medical Center.

How cancer cells move to the brain

Prof. Satchi-Fainaro and her colleagues Dr. Neta Erez of the Sackler Faculty's Department of Pathology, and Prof. Zvi Ram, head of the Department of Neurosurgery at Tel Aviv Medical Center received $900,000 for a proposal that explores how melanoma cells form metastases in distant organs, especially the brain. Prof. Satchi-Fainaro and her multidisciplinary team are working to identify the precise pro-metastatic factors secreted from astrocytes, special brain cells, which may constitute "druggable targets" for future nanotherapies.

"The whole field of nanomedicines for cancer is based on the fact that nanometric-size drugs (around 10-200 nanometers) are too large to leak out from normal blood vessels and harm healthy organs," said Prof. Satchi-Fainaro. "On the other hand, tumor blood vessels are incredibly leaky, so the nanomedicines can selectively exit from those blood vessels and accumulate at the tumor mass. Once at the tumor site, the new nanomedicines can inhibit the cross-talk between the melanoma cells and the brain microenvironment. We hope that our novel approach for co-targeting melanoma cells and astrocytes will pave the road for new clinical interventions."

A disarmament proposal for tumor cells

The MRA granted its second Team Science Award of $450,000 to Dr. Gal Markel and his team Dr. Tamar Geiger of TAU's Sackler Faculty of Medicine's Department of Human Molecular Genetics and Biochemistry, and Dr. Noam Shomron, director of TAU's Sackler Faculty of Medicine's Functional Genomics Laboratory. The focus of their study is to discover the mechanisms that allow tumors to evade the immune system, then to disarm those mechanisms, making the tumor susceptible to the patient's own immune response.

"Immunotherapy, which has existed for decades, has had slim success rates in melanoma treatment. But now, after new insights and developments over the last 10 years, it has become a hot topic everyone is discussing," said Dr. Markel. "We are focused on the immunology of melanoma how the immune system reacts to melanoma cells, how melanoma evades the immune system, and defining key processes."

Dr. Markel's team is working directly with melanoma patients who are treated with immunotherapy. "We are taking advantage of our years of unique clinical work, bringing it to the bench for a cutting-edge multi-faceted discovery process," Dr. Markel says.

To date, the MRA, which is the largest private funder of melanoma research, has awarded more than $51 million worldwide to advance prevention, diagnosis, and treatment. Based in Washington, DC, the alliance's ultimate goal is to find a cure by funding the most promising melanoma research worldwide that will accelerate progress and improve outcomes for patients and all who are at risk.


'/>"/>
Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Related medicine news :

1. University of Cincinnati researchers win $3.7M grant from US Department of Defense
2. Leading experts on congenital muscular dystrophy convene at University of Nevada, Reno
3. Rice University student engineers automate limb lengthening for kids
4. Louisiana Tech University professor earns NSF Early Career Development grant
5. Neuropsychologist receives University of Houstons highest faculty honor
6. University of Houston Graduate College of Social Work announces partnership with MD Anderson
7. Columbia University Medical Center and NY-Presbyterian experts at APA meeting
8. University of Minnesota startup to treat challenging bacterial infection
9. University studies and career expectations of medical students
10. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
11. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... , ... December 07, 2016 , ... One of two ... of the securement tape is painful for her. "This is why the co-inventor and ... heads," she said. , They then created a prototype of the patent-pending AV-AIR, a ...
(Date:12/7/2016)... ... ... Sharon Kleyne, host of the nationally syndicated radio program, The Sharon Kleyne ... declared on her radio program in November 2016 the need to educate people about ... leaders in corporate America, they are trying to take advantage of successful algorithms and ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... is condemning "scam operations" carried out by unethical locksmith companies and is urging ... to a halt. According to Texas Premier Locksmith, these fraudulent locksmith services take ...
(Date:12/7/2016)... ... December 07, 2016 , ... Gensuite ... Brilliance Awards under the Best New Product Launch category. Gensuite’s entry on their ... experience. , BOC Global Events & Training Group is a professional event and ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... “Tomorrow Trump ... Donald Trump bringing greatness back to the presidency and to America. “Tomorrow Trump Goes ... to do as much as she can for this country. , Nancy attributes her ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7,2016  Based on its ... industry, Frost & Sullivan recognizes Nemaura Pharma ... Sullivan Award for Enabling Technology Leadership. Nemaura ... loopholes in traditional drug delivery technologies, especially ... microneedle-based drug delivery technologies, Memspatch and Micropatch ...
(Date:12/7/2016)... , Dec. 7, 2016  Lannett Company, Inc. (NYSE: ... BMO Capital Markets 2016 Prescription for Success Healthcare Conference on December ... in New York City . In ... at the Guggenheim Securities 4 th Annual Boston Healthcare Conference ... ...
(Date:12/6/2016)... -- Radioisotopes are radioactive isotopes having an unstable balance ... nuclear research reactor or by using cyclotron. These isotopes ... gamma when changed to a stable nature. The gamma ... in medical diagnostics. In this field, the radiation is ... functioning. Radiotherapy is also used to treat some life-threatening ...
Breaking Medicine Technology: