Navigation Links
Teens of epileptic moms display poor school performance
Date:11/3/2010

A large population-based study revealed that multiple antiepileptic drugs (AEDs) used by pregnant women to control seizures may cause poor school performance in their teenagers. The research team from Karolinska University Hospital and the University of Lund in Sweden confirmed that exposure to AEDs in utero may have a negative effect on neurodevelopment. Their findings now appear online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy.

Prior studies suggest that exposure to AEDs in utero may cause permanent damage to exposed children. Cognitive and behavioral issues, malformations, psychomotor delay, and lower intelligence quotient (IQ) have all been reported in research of standard therapies for epilepsy. Medical evidence also points out that polytherapywhen multiple AEDs are usedis more harmful than monotherapy (single AED therapy).

The Swedish research team used the Medical Birth Register, Patient Register, and a local study to identify women with epilepsy who gave birth between 1973 and 1986, and their anticonvulsant use during pregnancy. Children's performance in school was obtained from the School Mark Registry, which provides grades for all students leaving compulsory school (age 16 in Sweden). Researchers then linked the data from all registers and identified 1,235 children born to epileptic mothers using AEDs, comparing their school performance to all other children born in Sweden (1,307,083) during the stated time period.

Results showed 641 children were exposed to monotherapy, 429 to polytherapy, and 165 to no known AED treatments in the womb. Those children exposed to two or more AEDs had an increased risk of not receiving a final grade upon completion of schooling, while those exposed to a single anticonvulsant, mainly carbamazepine (CBZ) or phenytoin, did not.

In finding that children exposed to a single AED had no increased risk of completing school without a final grade, the authors confirmed previous medical evidence that failed to show negative effects on nervous system development after exposure to monotherapy. However, the current study did show these children had a reduced chance of earning a "pass with excellence" grade, indicating that single AED use may impair higher cognitive function.

"Our results suggest exposure to several AEDs in the womb may have a negative effect on the child's neurodevelopment," said lead study author Lisa Forsberg, M.D. The findings support current recommendations based upon a study by Harden et al., that if adequate seizure control can be obtained, polytherapy should be replaced by monotherapy during pregnancy to reduce the risk of poor cognitive outcomes. "If possible pregnant women should avoid using multiple anticonvulsants to treat their seizures," concluded Dr. Forsberg.


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. For Many Teens, Oral Sex Leads to Riskier Activity
2. Study Finds Teens Late Night Media Use Comes at a Price
3. Half of Teens Treated for Depression Will Relapse: Study
4. Teens Should Get Meningitis Booster Shot: CDC Panel
5. Teens, Parents Often Lie About Illicit Drug Use
6. Binge Drinking, Pot Could Put Teens Intellect at Risk: Study
7. Weight-Loss Surgery for Teens May Be Gaining Advocates
8. 1 in 4 U.S. Teens and Young Adults Binge Drink: CDC
9. Anorexic Teens May Gain From Whole-Family Treatment
10. Study Finds Teens Think Sports Drinks Are Healthy
11. Use of sunless tanning products common in teens, may encourage sun safety in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
(Date:6/24/2016)... City, FL (PRWEB) , ... June 24, 2016 , ... ... inflammation common after venous procedures, dermaka cream can be incorporated into the post-surgical treatment ... and minor surgical procedures. , dermaka cream is very effective for bruising and ...
(Date:6/24/2016)... ... June 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located ... famous vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat ... Sedona as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
Breaking Medicine Technology: