Navigation Links
Teens of epileptic moms display poor school performance
Date:11/3/2010

A large population-based study revealed that multiple antiepileptic drugs (AEDs) used by pregnant women to control seizures may cause poor school performance in their teenagers. The research team from Karolinska University Hospital and the University of Lund in Sweden confirmed that exposure to AEDs in utero may have a negative effect on neurodevelopment. Their findings now appear online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy.

Prior studies suggest that exposure to AEDs in utero may cause permanent damage to exposed children. Cognitive and behavioral issues, malformations, psychomotor delay, and lower intelligence quotient (IQ) have all been reported in research of standard therapies for epilepsy. Medical evidence also points out that polytherapywhen multiple AEDs are usedis more harmful than monotherapy (single AED therapy).

The Swedish research team used the Medical Birth Register, Patient Register, and a local study to identify women with epilepsy who gave birth between 1973 and 1986, and their anticonvulsant use during pregnancy. Children's performance in school was obtained from the School Mark Registry, which provides grades for all students leaving compulsory school (age 16 in Sweden). Researchers then linked the data from all registers and identified 1,235 children born to epileptic mothers using AEDs, comparing their school performance to all other children born in Sweden (1,307,083) during the stated time period.

Results showed 641 children were exposed to monotherapy, 429 to polytherapy, and 165 to no known AED treatments in the womb. Those children exposed to two or more AEDs had an increased risk of not receiving a final grade upon completion of schooling, while those exposed to a single anticonvulsant, mainly carbamazepine (CBZ) or phenytoin, did not.

In finding that children exposed to a single AED had no increased risk of completing school without a final grade, the authors confirmed previous medical evidence that failed to show negative effects on nervous system development after exposure to monotherapy. However, the current study did show these children had a reduced chance of earning a "pass with excellence" grade, indicating that single AED use may impair higher cognitive function.

"Our results suggest exposure to several AEDs in the womb may have a negative effect on the child's neurodevelopment," said lead study author Lisa Forsberg, M.D. The findings support current recommendations based upon a study by Harden et al., that if adequate seizure control can be obtained, polytherapy should be replaced by monotherapy during pregnancy to reduce the risk of poor cognitive outcomes. "If possible pregnant women should avoid using multiple anticonvulsants to treat their seizures," concluded Dr. Forsberg.


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. For Many Teens, Oral Sex Leads to Riskier Activity
2. Study Finds Teens Late Night Media Use Comes at a Price
3. Half of Teens Treated for Depression Will Relapse: Study
4. Teens Should Get Meningitis Booster Shot: CDC Panel
5. Teens, Parents Often Lie About Illicit Drug Use
6. Binge Drinking, Pot Could Put Teens Intellect at Risk: Study
7. Weight-Loss Surgery for Teens May Be Gaining Advocates
8. 1 in 4 U.S. Teens and Young Adults Binge Drink: CDC
9. Anorexic Teens May Gain From Whole-Family Treatment
10. Study Finds Teens Think Sports Drinks Are Healthy
11. Use of sunless tanning products common in teens, may encourage sun safety in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... Phycologia ... A (UV-A) for photosynthesis, researchers Juntian Xu and Kunshan Gao tested the magnitude ... pair observed that when photosynthetically active radiation (i.e. the white light in our ...
(Date:5/5/2016)... ... 05, 2016 , ... Derrin Doty Group has unveiled the latest charity campaign ... communities west of Seattle. The insurance provider’s caring team has been so moved by ... due to complications from the flu, that they have decided to extend their original ...
(Date:5/5/2016)... ... May 05, 2016 , ... The University of ... to host the 2016 National SACA Leadership Conference on the Portland campus September ... chapter officers to come together and develop skills to be future leaders in ...
(Date:5/5/2016)... , ... May 05, 2016 , ... Vitenas Cosmetic Surgery ... Design Awards, presented by the American Institute of Architects and the Academy of Architecture ... the renowned Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... , ... Dr. Benjamin Stong of Kalos Facial Plastic Surgery, LLC in Atlanta, ... double board certified and the only facial plastic surgeon in Atlanta to offer ... such as stem cells can be used to provide stabilization to hair transplant results ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... According to market research "Global ... and Demand Forecast to 2022 - Industry Insights by ... Very High Field, Low to Mid Field, and Ultra ... Musculoskeletal, Vascular, Breast, Pelvic and Abdomen, Cardiac, and Other)" ... market was valued at $5,351.7 million in 2015, and ...
(Date:5/3/2016)... , May 3, 2016 Intec ... a clinical-stage biopharmaceutical company, today announced the appointment of ... Regulatory Affairs. "Ms. Strauss-Levy has 15 years ... has established an outstanding track record, having supported the ... regulatory approval processes in the United States ...
(Date:5/3/2016)... Global and Chinese Surgical ... overview of the industry that covers definition, applications ... report explores into the international and Chinese players ... Surgical Mesh market spread across 150 pages providing ... is available at http://www.reportsnreports.com/reports/470569-global-and-chinese-surgical-mesh-industry-2016-market-research-report.html . ...
Breaking Medicine Technology: