Navigation Links
Technique Tracks Cancer-Killing Cells
Date:11/19/2008

Innovative approach could aid research, treatment, experts say

WEDNESDAY, Nov. 19 (HealthDay News) -- U.S. researchers say they've developed a new long-term method of monitoring the location and survival of cancer-killing cells within the body.

Modifying a patient's own immune cells to find and attack infected or diseased cells is a promising treatment approach for many disorders, a team from Stanford University School of Medicine reports. However, efforts to track these cells after they've been reintroduced into the body have relied on short-term monitoring techniques that don't provide complete information about the cells' status.

According to the Stanford group, this new method can provide information about the status of these cells for months and possibly years, enabling researchers, doctors and patients to assess the cells' disease-fighting performance over time.

"This has never before been done in a human. Until now, we've been shooting blind, never knowing why failed therapies didn't work. Did the cells die? Did they not get where we wanted them to go? Now we can repeatedly monitor them throughout their lifetime," study senior author Dr. Sanjiv Gambhir, director of Stanford's molecular imaging program, explained in a university news release.

The new method involves two steps. First, the therapeutic cells are modified to express a reporter gene shared by no other cells in the body. Second, patients are injected with an imaging agent that's trapped only in cells expressing the reporter gene. The cells can then be tracked using a PET-CT scanner.

The technique was tested in a middle-aged man with an aggressive glioblastoma brain tumor. The researchers removed immune system killer T-cells from the man, and inserted genes that gave the T-cells the ability to find and destroy cancer. The modified T-cells were returned to the site of the man's brain tumor over a period of five weeks. The new imaging method showed the T-cells had moved into the tumor and also had traveled to a second, previously unidentified tumor site.

The study wasn't designed to assess the modified T-cells' ability to kill tumor cells, but the imaging results showed they did reach their targets.

The study was published Nov. 18 in the journal Nature Clinical Practice Oncology.

More information

The U.S. National Cancer Institute has more about biological therapies.



-- Robert Preidt



SOURCE: Stanford University, news release, Nov. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel imaging technique reveals brain abnormalities that may play key role in ADHD
2. Stress Spikes as Economy Tanks - Psychologist Identifies Why Traditional Stress Management Techniques Dont Work, and Offers Radical New Approach
3. New technique to study the genetics of breast cancer
4. Technique Preserves Future Fertility in Girls With Cancer
5. A biomagnetic diagnostic technique to evaluate esophageal transit time
6. Many Breast Cancer Patients Are Not Receiving Most Advanced Breast Conserving Surgical Techniques, New Study Finds
7. New Tummy Tuck Technique Increases Sensuality
8. New Technique Activates Brain Neurons to Move Paralyzed Limb
9. Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques
10. 3 Michigan Counties Participating in NIH Study of Cardiac Arrest Resuscitation Techniques
11. Bio-imaging mass spectrometry techniques reveal molecular details about complex systems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Technique Tracks Cancer-Killing Cells
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... 12, 2017 , ... Leading pediatric oncology experts at Children’s National Health ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired ... Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first interactive health literacy software tool, and the Cancer Patient Education Network (CPEN), ... patient education, today announce a new strategic alliance. , As CPEN’s strategic ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the University of California Berkeley, and other leading institutions in announcing the launch ... of institutions to change the way animals are raised for food. , Founding ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
Breaking Medicine Technology: