Navigation Links
Technique Tracks Cancer-Killing Cells
Date:11/19/2008

Innovative approach could aid research, treatment, experts say

WEDNESDAY, Nov. 19 (HealthDay News) -- U.S. researchers say they've developed a new long-term method of monitoring the location and survival of cancer-killing cells within the body.

Modifying a patient's own immune cells to find and attack infected or diseased cells is a promising treatment approach for many disorders, a team from Stanford University School of Medicine reports. However, efforts to track these cells after they've been reintroduced into the body have relied on short-term monitoring techniques that don't provide complete information about the cells' status.

According to the Stanford group, this new method can provide information about the status of these cells for months and possibly years, enabling researchers, doctors and patients to assess the cells' disease-fighting performance over time.

"This has never before been done in a human. Until now, we've been shooting blind, never knowing why failed therapies didn't work. Did the cells die? Did they not get where we wanted them to go? Now we can repeatedly monitor them throughout their lifetime," study senior author Dr. Sanjiv Gambhir, director of Stanford's molecular imaging program, explained in a university news release.

The new method involves two steps. First, the therapeutic cells are modified to express a reporter gene shared by no other cells in the body. Second, patients are injected with an imaging agent that's trapped only in cells expressing the reporter gene. The cells can then be tracked using a PET-CT scanner.

The technique was tested in a middle-aged man with an aggressive glioblastoma brain tumor. The researchers removed immune system killer T-cells from the man, and inserted genes that gave the T-cells the ability to find and destroy cancer. The modified T-cells were returned to the site of the man's brain tumor over a period of five weeks. The new imaging method showed the T-cells had moved into the tumor and also had traveled to a second, previously unidentified tumor site.

The study wasn't designed to assess the modified T-cells' ability to kill tumor cells, but the imaging results showed they did reach their targets.

The study was published Nov. 18 in the journal Nature Clinical Practice Oncology.

More information

The U.S. National Cancer Institute has more about biological therapies.



-- Robert Preidt



SOURCE: Stanford University, news release, Nov. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Novel imaging technique reveals brain abnormalities that may play key role in ADHD
2. Stress Spikes as Economy Tanks - Psychologist Identifies Why Traditional Stress Management Techniques Dont Work, and Offers Radical New Approach
3. New technique to study the genetics of breast cancer
4. Technique Preserves Future Fertility in Girls With Cancer
5. A biomagnetic diagnostic technique to evaluate esophageal transit time
6. Many Breast Cancer Patients Are Not Receiving Most Advanced Breast Conserving Surgical Techniques, New Study Finds
7. New Tummy Tuck Technique Increases Sensuality
8. New Technique Activates Brain Neurons to Move Paralyzed Limb
9. Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques
10. 3 Michigan Counties Participating in NIH Study of Cardiac Arrest Resuscitation Techniques
11. Bio-imaging mass spectrometry techniques reveal molecular details about complex systems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Technique Tracks Cancer-Killing Cells
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health ... Miles by Moonlight to raise money for the American Heart Association Heart Walk. Teams ... Teams will work together to keep their treadmills moving for 5 hours. Treadmills will ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017  PMD ... OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... strategic hub service that expedites and streamlines patient and ... Spiro PD 2.0, and wellness management services.  ... medical device used to measure lung function for a ...
Breaking Medicine Technology: