Navigation Links
Technique May Let More Women Use Tamoxifen
Date:2/23/2009

30% of breast cancers currently don't respond to this type of estrogen-linked drug

MONDAY, Feb. 23 (HealthDay News) -- Researchers have found a way to "switch on" estrogen sensitivity in breast tumor cells, thereby making them vulnerable to the breast cancer drug tamoxifen.

If successful, the technique might someday allow breast cancer patients who don't respond to tamoxifen to benefit from the drug.

"We're excited by the results," said study author Caroline Ford, a member of the department of cell and experimental pathology at Lund University in Malmo, Sweden. "This has implications for the 30 percent of breast cancer patients who are estrogen-receptor negative who currently have a poor prognosis."

Not only might these tumors become amenable to tamoxifen, but they may also respond to other "endocrine" treatments such as aromatase inhibitors, which also interfere with estrogen production in the body.

"We are currently investigating this," Ford said.

The findings may also provide alternatives for the group of women who start out estrogen receptor-positive but later become negative and for whom treatments stop working.

The findings are published in this week's issue of the Proceedings of the National Academy of Sciences.

As Ford noted, a large minority of patients have breast cancer tumors that do not express estrogen receptors. Not only does this make them unresponsive to a variety of treatments now available for estrogen receptor-positive malignancies, but it indicates a more aggressive cancer in general.

Tamoxifen, which has been a gold standard of breast cancer treatment for decades, works by binding to the estrogen receptor. If there is no receptor, however, tamoxifen becomes useless.

Any means of allowing the three out of 10 women whose cancers don't respond to tamoxifen and other endrocrine therapies would be a big advance, experts say.

"[Research] groups have been looking to restore positivity, to open the door to treatment with tamoxifen and aromatase inhibitors," said Dr. Minetta Liu, a translational researcher and breast oncologist at Georgetown University's Lombardi Comprehensive Cancer Center in Washington, D.C. The Swedish team now "have a molecule suggested that may, in fact, succeed. The findings are very exciting," he said.

So far, however, these promising results have only been seen in the lab and would need to be confirmed in animal models. If those experiments are successful, human trials would come next.

So how does the new technique work? In prior trials, researchers had noticed an association between cells that didn't express the estrogen receptor and a loss of expression of Wnt-5a, a key signaling protein.

This led to a theory that Wnt-5a might regulate estrogen receptor levels and, in fact, this seemed to be the case. Re-establishing Wnt-5a signaling resulted in higher estrogen receptor levels in estrogen receptor-negative cells.

But, the authors pointed out, Wnt-5a is probably too large a molecule to be administered directly to patients.

But Foxy-5, a smaller molecule and a Wnt-5a analog (look-alike) developed in the laboratory, did the same job as effectively, the team said.

Ford, along with a co-author of the paper, has filed a patent for the effects of the Foxy-5 peptide on estrogen receptors.

In related research, another study in the same issue of PNAS found that a protein called lipocalin 2 can indicate how invasive a breast cancer is likely to be. Better yet, levels of the protein can be measured in urine.

Apparently, lipocalin 2 decreases estrogen receptor levels, which indicates the presence of more aggressive cancer, according to researchers at Children's Hospital Boston.

Testing for the protein could help doctors and patients decide when more aggressive treatments might be appropriate.

More information

There's more on estrogen receptors at the U.S. National Cancer Institute.



SOURCES: Caroline Ford, Ph.D., department of cell and experimental pathology, Lund University, Malmo, Sweden; Minetta Liu, M.D., translational researcher/breast oncologist, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; Feb. 23-27, 2009, Proceedings of the National Academy of Sciences


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Eye-staining technique offers early detection for dry eye syndrome
2. New technique detects specific chromosomal damage, may indicate lung cancer risk
3. The Pharma & Life Sciences Best Practice Database: an Industry Resource for Successful Techniques and Performance Benchmarks for Reaching the Top
4. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
5. Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery
6. Radiation therapy technique reduces length of prostate cancer treatment
7. Radiation therapy technique reduces length of prostate cancer treatment
8. IVF technique enables pregnancy without multiple births, Stanford researchers find
9. UT Southwestern investigating hypothermic technique in treating pediatric head injuries
10. UCLA doctor develops new technique to treat varicose veins
11. New technique improves purity of medicines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Technique May Let More Women Use Tamoxifen
(Date:1/23/2017)... Switzerland (PRWEB) , ... January 23, 2017 , ... ... lab and production applications. However, choosing the right method is paramount to success. ... occur more often in situations where multiple persons use the same equipment. Rare ...
(Date:1/23/2017)... ... 2017 , ... Old School Labs™, makers of the wildly popular all-natural sports ... Ansley to its growing team of brand ambassadors. The Olympia top finisher and former ... than a year was able to turn professional, participating in the 2013 NPC USA ...
(Date:1/23/2017)... ... ... at the Mill”: a story of love and redemption, hope and uncertainty as a ... , “The Inn at the Mill” is the creation of published author, Lois Kulp, ... now living in Berks County on Crow Hill. The inn, the mill and ...
(Date:1/23/2017)... ... ... “Life Under Blankets”: an entrancing story about one woman's travels through the wilderness ... of published author, Kimberly Mitchell, who earned her bachelor’s degree in English education at ... master’s degree in education in the field of curriculum and instruction. Kimberly’s passion for ...
(Date:1/22/2017)... FRANCE (PRWEB) , ... January 22, 2017 , ... Phytocéane ... Ocean, isolated from the rest of the world with ZANZIBAR MILKY CREAM. Inspired by ... used key ingredients like Virgin Coconut Oil and moisturizing vegetal coral to create this ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... PALMA, Spain , January 23, ... a clinical-stage biopharmaceutical company focused on treatments for ... has been enrolled in the Phase IIb "CaLIPSO ... the treatment of cardiovascular calcification (CVC) in end-stage-renal-disease ... ESRD patients, in the last stage of chronic ...
(Date:1/21/2017)... , Jan 20, 2017 Research ... Clinical Laboratory Testing Market By Type of Test (Tumor, Clinical ... & By Type of Diseases (Tuberculosis, Influenza, Cancer, HIV/AIDS etc.), ... ... attractive destination for healthcare services, market segments, especially clinical lab ...
(Date:1/21/2017)... -- Research and Markets has announced the addition of ... Route Of Administration, End User - Forecast to 2025" report ... ... a CAGR of around 7.8% over the next decade to reach ... analyzes the global markets for Advanced Drug Delivery across all the ...
Breaking Medicine Technology: