Navigation Links
Team to study health effects of botanical estrogens
Date:9/8/2010

CHAMPAIGN, Ill. An ongoing research initiative into the health effects of botanical estrogens will get an $8 million boost from the National Institutes of Health.

The Botanical Research Center, based at the University of Illinois, will address the many unknowns associated with use of botanical estrogens. These plants and plant-based compounds are often marketed as aids to prevent cancer, promote healthy aging or relieve menopausal symptoms. Researchers from Illinois, the University of Mississippi, Oregon State University and the FDA's National Center for Toxicological Research will contribute to the five-year effort.

This is the second $8 million grant from the NIH to Illinois to conduct research into the health effects of botanical estrogens. The first five-year initiative focused on soy isoflavones, compounds found in soybean that previous studies indicated had potential as anti-cancer and cholesterol-lowering agents. That grant yielded studies that showed that the positive or negative health consequences of exposure to soy isoflavones depend on the timing of the exposure (whether it occurs in early, mid, or late life), tissue type (breast or brain, for example), and dose.

Many women take plant-based estrogens (also called phytoestrogens) that are advertised as natural and, they presume, safer alternatives to hormone-replacement therapy.

Foods, supplements and extracts made from soy, licorice root, wild yam and dong quai, for example, are believed to reduce the occurrence of hot flashes, improve sex drive, lower the incidence or prevent the recurrence of breast cancer, enhance mental function or treat other health problems.

Today, phytoestrogens are added to teas and energy drinks, used as food additives and marketed as nutritional supplements. The estrogenic components of the plants such as the isoflavone genistein in soy are often extracted and used in highly concentrated form.

Research into their efficacy and safety has yielded mixed results. Consumption of some plants or extracts appears to reduce the risk of some cancers or minimize some of the unpleasant symptoms associated with menopause, while others have no effect. Still other studies, some of them conducted at Illinois, have found that certain phytoestrogens may actually induce cognitive problems, increase the recurrence of breast cancer and interfere with breast cancer treatment.

"The types of botanical estrogens that are being marketed are getting more and more potent," said William Helferich, a professor of food science and human nutrition at Illinois and the director of the new center. "We want to see if they really are effective or detrimental."

The new grant supports three projects led by Illinois faculty. The projects will explore whether and how phytoestrogens from soy, licorice root, dong quai and wild yam affect various tissues, influence gene expression or other cellular processes, increase or decrease the growth and metastasis of breast cancer tumors, influence bone loss or alter the rate of cognitive decline in aging. Two core areas will provide support to the three projects by authenticating and standardizing the botanical samples used in the studies and analyzing how the various compounds are utilized in the body.

Benita Katzenellenbogen, a professor of molecular and integrative physiology and of cell and developmental biology at Illinois, will lead a project to study the effects of botanical estrogens on gene activation and their interaction with estrogen receptors and regulatory proteins.

Helferich will lead a project to investigate the effects of botanical estrogens on bone, uterus and mammary glands, and their effects on the growth and progression of breast cancer and its metastasis to bone, lung or other tissues.

Illinois comparative biosciences professor Susan Schantz will serve as the associate director of the center and together with Illinois psychology professor Donna Korol and Oregon State University professors Russ Turner and Urszula T. Iwaniec will lead a project to study the effects of botanical estrogens on cognitive function and bone health.

Ikhlas Khan, of the University of Mississippi, will authenticate and standardize botanical samples used in the research.

Daniel Doerge, of the FDA's National Center for Toxicological Research, will identify and quantify the samples used in the study and determine appropriate dosing.


'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert

Related medicine news :

1. Institute for Aging Research study finds indoor and outdoor fall are different for the elderly
2. Study finds more Americans bypassing their personal physician when immediate treatment required
3. Autistic Toddlers Prefer to Gaze at Geometric Patterns: Study
4. Many hospital emergency department visits could be treated elsewhere, study finds
5. Study examines association between urban living and psychotic disorders
6. Mouse Study May Help Explain Fish Oils Benefits
7. Infants May Display Subtle Autism Signs at 6 Months: Study
8. Queens study exposes cognitive effects of Parkinsons disease
9. Study challenges value of oxygen therapy in end-of-life care
10. Study finds that cancer-causing gene crucial in stem cell development
11. Safety cultures in EMS agencies vary widely, Pitt study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... Gowrie, IA (PRWEB) , ... February 28, 2017 , ... Webster-Calhoun Cooperative Telephone Association ... cooperative to be held on Tuesday, March 14th at 7:00 pm at the Southeast Valley ... is "Set Your Sights For Great Service" What do you look for in ...
(Date:2/28/2017)... , ... February 28, 2017 , ... In 2014, Harvard ... In studying approximately 800 deaths from prostate cancer, the researchers found that men who ... more likely to get fatal prostate cancer. Although the increased risks are small, they ...
(Date:2/28/2017)... (PRWEB) , ... February 28, 2017 , ... BrightStar Care ... of Choice Awards from Home Care Pulse. This award is granted only to top-ranking ... BrightStar Care Marietta is now ranked among home care providers from across the ...
(Date:2/27/2017)... ... February 27, 2017 , ... It’s ... strength, which often leads to a host of health issues, including urinary incontinence. ... Geriatrics Society discovered that good overall muscle strength in older women, particularly ...
(Date:2/27/2017)... ... February 27, 2017 , ... Much attention has been paid to the ... dependent on opioid painkillers has fallen short. From 1999 until 2010, fatal overdoses from ... in fatal overdoses in male populations.(1) , The proportion of women using illicit drugs ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... 2017 The global  pulse oximeters market  is expected to ... View Research, Inc. The pulse oximeters market is anticipated to witness significant growth ... target diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea, cardiac arrhythmia, ... ... Grand View Research Logo ...
(Date:2/28/2017)... 2017  Summary This report provides all ... its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since 2010 report ... one of the world,s leading life sciences companies. ... to ensure inclusion of the most up to date ...
(Date:2/28/2017)... 28, 2017 Research and Markets has ... Forecasts 2014-2025" report to their offering. ... The global digestive ... by 2025. Growing consumer awareness regarding the severity of digestive ... to stimulate industry growth over the forecast period. The increasing ...
Breaking Medicine Technology: