Navigation Links
Team solves mystery associated with DNA repair
Date:12/13/2012

CHAMPAIGN, lll. Every time a human or bacterial cell divides it first must copy its DNA. Specialized proteins unzip the intertwined DNA strands while others follow and build new strands, using the originals as templates. Whenever these proteins encounter a break and there are many they stop and retreat, allowing a new cast of molecular players to enter the scene.

Scientists have long sought to understand how one of these players, a repair protein known as RecA in bacterial cells, helps broken DNA find a way to bridge the gap. They knew that RecA guided a broken DNA strand to a matching sequence on an adjoining bit of double-stranded DNA, but they didn't know how. In a new study, researchers report they have identified how the RecA protein does its job.

"The puzzle for scientists has been: How does the damaged DNA look for and find its partner, the matching DNA, so that it can repair itself?" said University of Illinois physics professor Taekjip Ha, who led the study. "Because the genomic DNA is millions of bases long, this task is much like finding a needle in a haystack. We found the answer to how the cell does this so quickly."

The research is described in a paper in eLife, a new open-access journal supported by the Howard Hughes Medical Institute (HHMI), the Max Planck Society and the Wellcome Trust. Ha is an HHMI investigator. The National Science Foundation provided primary funding for this work.

DNA repair is vital to health, vitality and longevity. Disruptions of the process can lead to the early onset of diseases associated with aging or cancer in animals. The breast cancer mutation known as BRCA2, for example, disrupts a gene involved in loading Rad51 (the human equivalent of RecA) onto a broken DNA strand to begin the process of repair.

Previous studies h
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Solving a biological mystery
2. Cell death mystery yields new suspect for cancer drug development
3. Danish scientists solve old blood mystery
4. Solving the Medical Mystery of Cold Feet
5. Solving the mystery of how cigarette smoking weakens bones
6. 50-year cholera mystery solved
7. Mystery of the missing breast cancer genes
8. Scientists solving the mystery of human consciousness
9. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
10. Study suggests vision insurance associated with eye-care visits, better reported vision
11. Pitt research sheds new light on virus associated with developmental delays and deafness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team solves mystery associated with DNA repair
(Date:3/26/2015)... CA (PRWEB) March 26, 2015 Dr. ... are proud to announce expanded offerings for Bay Area ... Francisco Dental Implant Center has long been a top-rated ... expanded its offerings to meet the strong demand by ... our reputation as a top-rated dental implant facility in ...
(Date:3/26/2015)... Springs, FL (PRWEB) March 26, 2015 ... of the nation’s leading innovative specialty pharmacies, announces ... created position of Vice President of Pharmaceutical Relations. ... fostering beneficial connections with our pharmaceuticals partners and ... relationships in support of BioPlus’ expansion. , ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 In the key ... as of 2013 and is set to decrease through 2020 ... 2020; the growth is expected up to 2017 at a ... expected to be owing to the surging penetration of fixed-dose ... Twynsta, Micardis Plus, Valturna, Benicar HCT, and Tekamlo), a hike ...
(Date:3/26/2015)... Sunrise, FL (PRWEB) March 26, 2015 ... unveiled its brand-new, state-of-the-art company website: http://www.metabolicnutrition.com ... of the revamped website creates a user-friendly experience ... supplement company. , The new, enhanced Metabolic ... Comprehensive information about the company’s diverse line of ...
(Date:3/26/2015)... Zane Benefits, the leader in individual ... eBook, “The Comprehensive Guide To Interviewing For Your Small ... most important aspect of the hiring process. Many small ... right way, possibly resulting in thousands of dollars lost. ... yet it’s essential to the success of your small ...
Breaking Medicine News(10 mins):Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 3Health News:BioPlus Specialty Pharmacy Expands Executive Team with New Position, Naming Sharon Ferrer as Vice President of Pharmaceutical Relations 2Health News:Top 8 Developed Anti-Hypertensive Therapeutics Markets Discussed in New GBI Research Report Published at MarketPublishers.com 2Health News:Top 8 Developed Anti-Hypertensive Therapeutics Markets Discussed in New GBI Research Report Published at MarketPublishers.com 3Health News:Metabolic Nutrition Launches Sleek New Website with New Features and Enhanced Consumer Information 2Health News:Zane Benefits Announces: New eBook: The Comprehensive Guide To Interviewing For Your Small Business 2
... ... ... of complex government regulation some of the stand-out questions include:, , ,   ... How are these standards impacted by the convergence of media and conflation of traditional media ...
... , ... ... ... ...
... ... ... ... ...
... study has confirmed earlier study results that 400 ... efficacy and tolerability for patients with uncontrolled partial-onset ... additional benefit for some patients. Researchers from the ... Center, Thomas Jefferson University Medical School, Arkansas Epilepsy ...
... The maximal standardized uptake value (called SUVmax) measured ... tumor in head and neck squamous cell carcinoma ... disease-specific survival, overall survival and disease-free survival, while ... distant metastasis, according to a study presented at ...
... Natural defense against the disease could be more common than ... The seemingly miraculous recovery from rabies of a 17-year-old Texas ... is leaving doctors scratching their heads and wondering if such ... case "suggests the rare possibility that abortive rabies can occur ...
Cached Medicine News:Health News:Alan Chapell, President of Chapell & Associates to Deliver Keynote at the Next AdMonsters US Leadership Forum 2Health News:Alan Chapell, President of Chapell & Associates to Deliver Keynote at the Next AdMonsters US Leadership Forum 3Health News:Highmark Inc. Prepares Now for the Diversity Boom Ahead 2Health News:Highmark Inc. Prepares Now for the Diversity Boom Ahead 3Health News:Highmark Inc. Prepares Now for the Diversity Boom Ahead 4Health News:Providence Service Corporation to Present at the RBC Capital Markets Healthcare Conference on Tuesday, March 2nd 2Health News:Providence Service Corporation to Present at the RBC Capital Markets Healthcare Conference on Tuesday, March 2nd 3Health News:Providence Service Corporation to Present at the RBC Capital Markets Healthcare Conference on Tuesday, March 2nd 4Health News:Lacosamide validated as promising therapy for uncontrolled partial-onset seizures 2Health News:Lacosamide validated as promising therapy for uncontrolled partial-onset seizures 3Health News:Pretreatment SUV associated with head and neck cancer treatment outcomes, may help decide treatment plans 2Health News:Texas Girl Recovers From Rabies Without Intensive Care 2
(Date:3/26/2015)... Columbia, March 26, 2015  OncoGenex Pharmaceuticals, Inc. ... of clinical developments and announced fourth quarter and ... Clinical Developments and Anticipated Near-term MilestonesCustirsen ... agreed to negotiate the termination of their collaboration ... the final termination agreement are ongoing. , ...
(Date:3/26/2015)... , March 26, 2015  CCS Medical ... home medical supplies for patients with chronic conditions, ... and Chief Executive Officer, effective March 23.  Mr. ... telehealth company, where he was President of Operations. ... was President and Executive Vice President of Operations ...
(Date:3/26/2015)... , March 26, 2015 Zimmer Holdings, Inc. ... new mobile app designed to serve as a feature-rich resource ... product. For those experiencing knee pain, the ... about the causes of knee pain and helps them understand ... a safe and simple non-surgical treatment option. For those who ...
Breaking Medicine Technology:OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 2OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 3OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 4OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 5OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 6OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 7OncoGenex Pharmaceuticals, Inc. Reports Financial Results for Fourth Quarter and Year End 2014 8CCS Medical Team Hires Industry Operator Rodney Carson as CEO 2Zimmer Launches New Patient Education And Engagement Mobile App For Gel-One Hyaluronate 2
... VSCP ), a provider of quantitative imaging for clinical ... 30, 2010 exceeded $3.5 million, representing a greater than 25% ... than 9% growth over the preceding quarter ended June 30, ... September 30, 2010 compared to the same period in 2009. ...
... Amex: PTN ) announced that it will be ... October 6, 2010 at 8:00 AM PT.  Hosted by the ... will take place October 5-6 at the Palace Hotel in ... and Chief Executive Officer of Palatin Technologies, will provide an ...
Cached Medicine Technology:VirtualScopics Revenues Hit Another Quarterly Record 2VirtualScopics Revenues Hit Another Quarterly Record 3
... Cochrane Reviews enable all those involved with ... with the very latest evidence in their ... becomes harder each year as the volume ... problem by delivering the best single source ...
Muscles Anatomy Flash Cards uses the time tested content and images from BryanEdwards.com....
Pocket Sports Medicine is the result of a collaboration between outstanding Editors and Contributors. The program covers the field so that both specialists and general orthopedists will find expert g...
... Cochrane Reviews enable all those involved with ... with the very latest evidence in their ... becomes harder each year as the volume ... problem by delivering the best single source ...
Medicine Products: