Navigation Links
Team solves mystery associated with DNA repair
Date:12/13/2012

CHAMPAIGN, lll. Every time a human or bacterial cell divides it first must copy its DNA. Specialized proteins unzip the intertwined DNA strands while others follow and build new strands, using the originals as templates. Whenever these proteins encounter a break and there are many they stop and retreat, allowing a new cast of molecular players to enter the scene.

Scientists have long sought to understand how one of these players, a repair protein known as RecA in bacterial cells, helps broken DNA find a way to bridge the gap. They knew that RecA guided a broken DNA strand to a matching sequence on an adjoining bit of double-stranded DNA, but they didn't know how. In a new study, researchers report they have identified how the RecA protein does its job.

"The puzzle for scientists has been: How does the damaged DNA look for and find its partner, the matching DNA, so that it can repair itself?" said University of Illinois physics professor Taekjip Ha, who led the study. "Because the genomic DNA is millions of bases long, this task is much like finding a needle in a haystack. We found the answer to how the cell does this so quickly."

The research is described in a paper in eLife, a new open-access journal supported by the Howard Hughes Medical Institute (HHMI), the Max Planck Society and the Wellcome Trust. Ha is an HHMI investigator. The National Science Foundation provided primary funding for this work.

DNA repair is vital to health, vitality and longevity. Disruptions of the process can lead to the early onset of diseases associated with aging or cancer in animals. The breast cancer mutation known as BRCA2, for example, disrupts a gene involved in loading Rad51 (the human equivalent of RecA) onto a broken DNA strand to begin the process of repair.

Previous studies h
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Solving a biological mystery
2. Cell death mystery yields new suspect for cancer drug development
3. Danish scientists solve old blood mystery
4. Solving the Medical Mystery of Cold Feet
5. Solving the mystery of how cigarette smoking weakens bones
6. 50-year cholera mystery solved
7. Mystery of the missing breast cancer genes
8. Scientists solving the mystery of human consciousness
9. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
10. Study suggests vision insurance associated with eye-care visits, better reported vision
11. Pitt research sheds new light on virus associated with developmental delays and deafness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Team solves mystery associated with DNA repair
(Date:5/22/2013)... (PRWEB) May 22, 2013 Jury deliberations are ... trial involving a da Vinci lawsuit, Bernstein Liebhard ... family of a man who allegedly died of da Vinci ... $8 million in damages from Intuitive Surgical, Inc. Among ... training program for the da Vinci Surgical System in its ...
(Date:5/22/2013)... Reporter , , WEDNESDAY, May 22 (HealthDay News) -- Anyone ... is something about feet that fungi seem to like. ... the fungal groups that live on your skin -- ... It,s no secret that the human body is ... fungi, both outside and inside. And it,s mainly a ...
(Date:5/22/2013)... 2013 DePuy Pinnacle lawsuit ... Hip Replacement System continue to move forward in the ... LLP reports. According to an Order dated May ... monitoring reports associated with a 2007 criminal investigation by ... practices. Plaintiffs maintained in their December 2012 ...
(Date:5/22/2013)... UT (PRWEB) May 22, 2013 Today, ... Alabama Health Insurance Exchange . Zane Benefits, which ... health benefits, is the leader in defined contribution ... According to Zane Benefits’ website, beginning in 2014 as ... coverage for individuals and small businesses will become available ...
(Date:5/22/2013)... may be reaping enormous income for patients whose ... contracted in their intensive care units. , In ... American Journal of Medical Quality , the ... an avoidable central line-associated bloodstream infection (CLABSI) costs ... a similar infection-free patient. Moreover, hospitals earn nearly ...
Breaking Medicine News(10 mins):Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 2Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 3Health News:Da Vinci Robot Lawsuits: Bernstein Liebhard LLP Notes Beginning of Jury Deliberations in Nation’s First Trial Involving Alleged Da Vinci Surgery Complications 4Health News:Scientists Map the Fungi on Your Feet 2Health News:Scientists Map the Fungi on Your Feet 3Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Notes New Order in Federal Pinnacle Litigation Requiring Production of Monitoring Reports from Federal Investigation 3Health News:Zane Benefits Publishes New Information on Alabama Health Insurance Exchange 2Health News:Zane Benefits Publishes New Information on Alabama Health Insurance Exchange 3Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4
... study done by business advisory organization Grant Thornton International said ... Western counterparts. This is due to fewer holidays, business travel ... increase in the adrenalin rush among people in Taiwan, China ... owners in 30 countries, all of ,whom reported some rise ...
... dioxide emissions have rendered the oceans acidic, threatening the ... occurrence, akin to what happened to the dinosaurs, some ... the face of the earth. Ken Caldeira of the ... research at the AGU/ASLO Ocean Sciences meeting in Honolulu. ...
... that babies breastfed for six months have reduced respiratory ... was conducted by investigators at UC Davis Children's Hospital, ... Pediatrics, Center for Child Health Research. ,In ... Davis Children's Hospital, lead author, "We found that babies ...
... Chicago is doing a good job to facilitate paired donor ... after they registered with this organization.// ,A case of ... from their wives because of blood group mismatch, met at ... each other’s husbands. This has indeed given the husband’s a ...
... Melanoma, a form of skin cancer is the most common tumor ... early, say researchers from University Hospital of Navarra. // Sadly, the ... is the number one killer of women aged between 19 and ... risen from 6000 to 9000 in just 10 years. ...
... of a child, to determine the location and number of hemorrhages ... discussed in the American Academy of Forensic Sciences annual meeting held ... located behind the eye. Any rupture in the retinal surface can ... retinal hemorrhage. , A wide variety of conditions such ...
Cached Medicine News:Health News:New Technique Could Revolutionize Melanoma Diagnosis and Treatment 2Health News:Retinal Hemorrhage: No More a Sure Sign of Child Abuse 2
(Date:5/22/2013)... May 22, 2013 Attorney Advertising -- Bronstein, ... on behalf of purchasers of the securities of ... AMAG -News).  The investigation focuses on whether the ... On May 22, 2013, Shares of ... after the company announced in regulatory filing that ...
(Date:5/22/2013)... 22, 2013   Accuray Incorporated (Nasdaq: ... scheduled to present at the 2013 Jefferies Global Healthcare ... Thursday, June 6, 2013 at 1:30 p.m. EDT/10:30 a.m. ... will be available online from the Investor Relations page ... The webcast replay of the presentation will begin approximately ...
(Date:5/22/2013)... , May 22, 2013 JenaValve Technology, Inc., a ... implantation (TAVI) systems for the treatment of aortic valve disease, ... enaValve Eval U ation of Long Term P erformance ... E vere Ao R tic Stenosis (JUPITER) Registry at EuroPCR ... registry to evaluate five-year long term safety and effectiveness of ...
Breaking Medicine Technology:Bronstein, Gewirtz & Grossman, LLC Announces Investigation of AMAG Pharmaceuticals, Inc. 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 2First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 3First Results Of The JUPITER Registry On Long Term Performance And Safety Of The Transapical JenaValve TAVI System 4
... 5, 2011 Oncimmune ® LLC, maker of EarlyCDT™-Lung ... assessment and early detection of lung cancer , today announces ... test: audit of 1,000 patients in clinical practice" supports ... with sensitivity for non-small cell lung cancer (NSCLC) at least as ...
... D. Smith, the fourth largest national pharmaceutical wholesaler, announced ... Bruin as corporate vice president managed care.  De Bruin ... and managed care experience, his senior and strategic-level pharmacy ... new position at H. D. Smith, de Bruin will ...
Cached Medicine Technology:First Reportable Data of EarlyCDT™-Lung Use in Clinical Practice Presented at IASLC World Conference on Lung Cancer 2First Reportable Data of EarlyCDT™-Lung Use in Clinical Practice Presented at IASLC World Conference on Lung Cancer 3First Reportable Data of EarlyCDT™-Lung Use in Clinical Practice Presented at IASLC World Conference on Lung Cancer 4First Reportable Data of EarlyCDT™-Lung Use in Clinical Practice Presented at IASLC World Conference on Lung Cancer 5H. D. Smith Appoints Mark de Bruin Corporate Vice President Managed Care 2
... multiple core biopsies of soft tissue. Lightweight ... facilitates one-handed control. Precise, rapid firing mechanism ... stylet permits easy penetration into the specimen ... cutting edge of cannula helps assure an ...
... the iQ®200 Automated Urine Microscopy Analyzer ... Automated Urine Chemistry Analyzer (AX-4280) to ... microscopic analysis. The iQ200 uses Auto-Particle ... network, to classify and quantitate twelve ...
... The Iris Diagnostics iQ®200 Automated ... imaging and Auto-Particle Recognition (APR®) software ... categories and quantitatively report results. The ... to prepare and interpret particle images ...
... Alpha has been designed as a compact, ... hospitals, offices, private clinics or as a ... and the most commonly required investigations such ... included. Add-on options are available for ...
Medicine Products: