Navigation Links
Team reveals molecular mechanism underlying a form of diabetes
Date:9/8/2009

By investigating a rare and severe form of diabetes in children, University of Iowa researchers have discovered a new molecular mechanism that regulates specialized pancreatic cells and insulin secretion. The mechanism involves a protein called ankyrin, which UI researchers previously linked to potentially fatal human heart arrhythmias.

The findings, which appear this week in the Early Edition of the Proceedings of the National Academy of Sciences, may help identify new molecular targets for treating both rare and common forms of diabetes and hyperinsulinemia.

The Centers for Disease Control and Prevention estimates that 23.6 million people have diabetes in the United States. The condition doubles the risk of death and includes complications such as heart disease, stroke, eye and kidney problems, and peripheral vascular disease.

The University of Iowa team, working with researchers at Washington University in St. Louis, used animal and cellular models to focus on a gene mutation linked with permanent neonatal diabetes mellitus. Children with this genetic form of diabetes have symptoms by age 6 months and require lifelong dependence on insulin to maintain proper glucose levels.

The team discovered that the specific human gene mutation disrupts the ability of the protein ankyrin to regulate a key protein complex known as the KATP channel.

"We have known for some time that human mutations in the KATP channel complex may cause diabetes or hyperinsulinemia," said Faith Kline, Ph.D., the study's lead author and postdoctoral fellow in internal medicine in the University of Iowa Carver College of Medicine. "Now we know something about how this specific KATP channel mutation results in disease.

"The KATP channel essentially functions as a gatekeeper for insulin secretion by pancreatic beta cells. Without proper regulation by this gatekeeper, the pancreatic beta cells are unable to efficiently regulate
'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-356-7127
University of Iowa
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. Survey reveals disparities in skin cancer knowledge, protection among high school students
3. Large intensive care study reveals vital recommendations for treatment of brain injury patients
4. Inc. Magazine Reveals Its 26th Annual List of Americas 500 Fastest-Growing Private Companies
5. Survey From The Partnership and MetLife Foundation Reveals Important Role Todays Grandparents Play in Teens Lives
6. New Survey Reveals Kidney Patients Concern About Medicare Policies
7. UCSD study reveals the regulatory mechanism of key enzyme
8. UCSD study reveals the regulatory mechanism of key enzyme
9. Poll reveals public awareness of nanotech stuck at low level
10. Survey reveals ignorance and confusion about cancer amongst the elderly
11. Story Reveals How Isabel and Her Family Learn About Bone Health and Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... new pain relief targets that could be used ... at King,s College London made the discovery when ... periphery of the body. , Dr Marzia Malcangio ... underlying pain generation and our findings could help ... , One potential side effect of some chemotherapy ...
(Date:4/17/2014)... In the April issue of Experimental Biology ... by Drs. Rex Gaskins and Paul Kenis in ... campus of the University of Illinois Urbana-Champaign describe ... reduction-oxidation reactions underlie a variety of cell functions ... to these crucial roles in regulating normal cellular ...
(Date:4/17/2014)... NY In a review published in the April ... president of The Feinstein Institute for Medical Research, says ... medical community,s approach to treating sepsis, which ... Americans. , Sepsis occurs when molecules released into the ... throughout the body. Inflammation is necessary for maintaining good ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
(Date:4/17/2014)... The cause of neuronal death in Parkinson,s disease is ... may be mistaken for foreign invaders and killed by ... autoimmune diseases like type I diabetes, celiac disease, and ... published April 16, 2014, in Nature Communications . ... in Parkinson,s disease; but if true, it could lead ...
Breaking Medicine News(10 mins):Health News:New pain relief targets discovered 2Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Is Parkinson's an autoimmune disease? 2
... One of the largest individual studies of the effects of ... it makes no difference whether a woman drinks wine, beer ... alcohol) and the quantity consumed that is likely to trigger ... drinking three or more alcoholic drinks a day is similar ...
... today that Sanofi-Aventis has renewed its licenses ... Analysis Pipeline., The pipeline provides a fully ... of expression and tiling microarray experiments, including ... software module ChipInspector seamlessly integrates with additional ...
... liquor present same risk, OAKLAND, Calif., Sept. 27 ... of alcohol on the risk of breast cancer shows ... beer or spirits,(liquor). It is the alcohol itself (ethyl ... In fact, the increased breast,cancer risk from drinking three ...
... Acquisition to Expand Thomson Scientific,s Market-leading Portfolio of ... Chemistry and Drug Discovery Information Solutions, STAMFORD, Conn., ... TSX: TOC), a leading provider of information,solutions to business ... Prous Science, a global leader in the provision of,life ...
... Albemarle,Corporation (NYSE: ALB ), a global ... the price of its Ibuprofen 40 micron,and Ibuprofen ... Ibuprofen 20 micron,product by 20 percent, worldwide, effective ... http://www.newscom.com/cgi-bin/prnh/20050801/ALBEMARLELOGO ) "Albemarle proudly stands ...
... In a letter,sent today to California Assembly Speaker ... Consumer Rights (FTCR) urged their,opposition to any health care ... Gov. Arnold Schwarzenegger and Assembly Speaker Fabian Nunez ... care reform that will require every,Californian to prove they ...
Cached Medicine News:Health News:Wine, women and... spirits, beer and breast cancer risk 2Health News:Wine, women and... spirits, beer and breast cancer risk 3Health News:Kaiser Permanente Study Shows Alcohol Consumption - No Matter Beverage Type - Linked to Breast Cancer Risk 2Health News:Kaiser Permanente Study Shows Alcohol Consumption - No Matter Beverage Type - Linked to Breast Cancer Risk 3Health News:Kaiser Permanente Study Shows Alcohol Consumption - No Matter Beverage Type - Linked to Breast Cancer Risk 4Health News:Thomson Acquires Prous Science 2Health News:Thomson Acquires Prous Science 3Health News:Thomson Acquires Prous Science 4Health News:Albemarle to Increase Price of Ibuprofen 2Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 2Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 3Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 4Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 5Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 6Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 7Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 8Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 9Health News:Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance 10
(Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... Oct. 27 According to Millennium Research Group ... intelligence, the European arthroscope market generated over $30 ... over 2009 due to decreasing scope prices and ... Due to unfavorable economic conditions, manufacturers are ...
... today announced that it has received approval from the ... (US 7,815,929) regarding a method for the preparation, storage ... very nature, the process of compounding suppositories is cumbersome, ... Indu Muni, founder, chairman, and CEO of CutisPharma, Inc. ...
Cached Medicine Technology:Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 2Despite Rising Procedure Volumes, the $30 Million European Arthroscope Market Experienced Nominal Growth in 2010 3CutisPharma Announces Issuance of an Additional Patent for Suppository Compounding 2
The CT100 mounts conveniently on your slit lamp and can be positioned in front of your patient as required. The prism is viewed through the left microscope objective. The tonometer can be removed fro...
... networked solutions are delivered with a Managed ... purchase software upgrades again; utilize our non-proprietary ... of your healthcare facility. ,COMBINING RESOURCES - ... old and new equipment; we use the ...
... Cardiology is the first digital solution designed ... both within and outside cardiology. From the ... archival solutions, Agfas combined expertise in both ... their customers to work the way they ...
Full Digital Ultrasound System...
Medicine Products: