Navigation Links
Team pinpoints amino acid variation in immune response gene linked with ulcerative colitis
Date:12/15/2011

PITTSBURGH, Dec. 15 The association between the inflammatory bowel disease ulcerative colitis and a gene that makes certain cell surface proteins has been pinpointed to a variant amino acid in a crucial binding site that profoundly influences immune response to antigens, including gut bacteria, reports a team of researchers at the University of Pittsburgh, Cleveland Clinic, Carnegie Mellon University and Harvard Medical School. They published the findings today in the online version of Genes & Immunity.

Variations in genes that regulate immune responses in a region of chromosome 6 have long been linked with susceptibility for many infectious and chronic inflammatory conditions, including ulcerative colitis, said Richard H. Duerr, M.D., professor of medicine, Pitt School of Medicine, co-director and scientific director, UPMC Inflammatory Bowel Disease Center, and the corresponding author of the study. Ulcerative colitis is characterized by recurrent inflammation of the large intestine that results in diarrhea mixed with blood and abdominal pain.

"We tested more than 10,000 points, called single nucleotide polymorphisms, or SNPs, in the gene sequence in this chromosomal region, and we also tested amino acid variations in human leukocyte antigen (HLA) proteins that were deduced from the SNPs to identify those most important for ulcerative colitis," Dr. Duerr said. "Refining the gene association signals in this region enabled us to better understand the underlying mechanisms of the disease."

Using sophisticated association techniques, the authors confirmed that an HLA gene called DRB1, which codes for a protein that is involved in the immune response and routinely tested in tissue matching for organ transplantation, was uniquely related to ulcerative colitis. Variation, or polymorphism, in that gene altered which amino acid was selected for the 11th position in the DRB1 protein a key location because it is in a pocket of the so
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Expert Panel Pinpoints Environmental Culprits in Breast Cancer
2. Study of golf swings pinpoints biomechanical differences between pros and amateurs
3. Project Achilles pinpoints vulnerabilities in ovarian cancer
4. York U study pinpoints part of brain that suppresses instinct
5. Ultrasensitive detector pinpoints big problem in tiny fetal heart
6. Too Much Acetaminophen Over Time May Damage Liver
7. Maypros Japanese partner, Amino Up Chemical, opens new production facility
8. Study links acetaminophen to lower prostate cancer risk
9. Drugmakers to End Infant Formulas of Products With Acetaminophen
10. FDA Lowers Amount of Acetaminophen Allowed in Prescription Painkillers
11. Acetaminophen use in adolescents linked to doubled risk of asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... " Bubbly Walrus ” was featured on ... look at the latest and coolest applications on the market ... AppWatch and technology expert, conducted the app review and shared ... , The best games to play on smartphones are the ... killing brain cells with a video game that just absorbs ...
(Date:5/3/2015)... 03, 2015 NuevaCare announced today that ... upcoming area seminars. The first event will take place ... Stroke Conference to be held at The Magnolia of ... May 13 during the Dementia Conference to be held ... seminars offer an excellent opportunity to learn about the ...
(Date:5/2/2015)... May 03, 2015 As one of ... the prestigious Safety and Health Achievement and Recognition Program ... to be chosen by the Illinois Department of Labor ... achieved and maintained SHARP certification by the Occupational Safety ... as Essentra has continued to meet or exceed all ...
(Date:5/2/2015)... May 02, 2015 ProText Kinetic 2 is ... in Final Cut Pro X. ProText Kinetic 2 features ... Final Cut Pro X . Easily create interactive ... Pixel Film Studios' ProText Kinetic 2. , Using ProText Kinetic ... staggering two ProText Kinetic presets in the FCPX timeline. ...
(Date:5/2/2015)... 2015 On Tuesday April 7th, the ... gathered to celebrate improvements in patient care. In 2014 ... (RVHP), had zero acquired ventilator associated infections, zero central ... ELCH was also recently named a Top Performer by ... ELCH credited the teamwork of staff from all departments ...
Breaking Medicine News(10 mins):Health News:An Application to Have Fun with Mathematics Was Featured on NewsWatch Television 2Health News:NuevaCare Introduces MnemeTherapy® Approach to Care for Elderly Patients with Alzheimer’s, Stroke and Other Types of Neurodegenerative Conditions 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... same period in Fiscal 2008 -, ... otherwise noted),BELLEVILLE, ON, May 6 /PRNewswire-FirstCall/ - Bioniche ... Canadian biopharmaceutical company, today announced financial results for ... ending March 31, 2009. , "The year-to-date revenue ...
... (NYSE: GSK ) today announced that it has ... Wellbutrin XL (R) in the United States ... (NYSE, TSX: BVF), for $510 million (euro 340 million). ... United States.Generic competition to Wellbutrin XL began at ...
... Outside of Houston PHOENIX, May 6 Today ... D. Anderson Cancer Center announced they will create the M. ... leading provider of health care and the nation,s leading cancer ... level of cancer care in Arizona.Located at US 60 and ...
... for generous contribution to New York University College of Dentistry ... ... D.D.S. and his wife, Ellen Linhart, have established the New York ... Linhart’s alma mater. In honor of this act of philanthropy, New ...
... Max Muscle Sports Nutrition,s newest product innovation is L-Tox, for advanced ... along with protective and regenerative factors. , ... Anaheim, ... Administration (FDA) www.fda.gov issued a stop product use directive ...
... to the transition from in-patient to outpatient care for diabetes patients ... discussion on the Diabetes Best Practices Website provide up-to-date information and ... ... 6, 2009 -- "Diabetes Discharge planning is a national priority," says ...
Cached Medicine News:Health News:Bioniche Reports Fiscal 2009 Third Quarter 2Health News:Bioniche Reports Fiscal 2009 Third Quarter 3Health News:Bioniche Reports Fiscal 2009 Third Quarter 4Health News:Bioniche Reports Fiscal 2009 Third Quarter 5Health News:Bioniche Reports Fiscal 2009 Third Quarter 6Health News:Bioniche Reports Fiscal 2009 Third Quarter 7Health News:Bioniche Reports Fiscal 2009 Third Quarter 8Health News:Bioniche Reports Fiscal 2009 Third Quarter 9Health News:Bioniche Reports Fiscal 2009 Third Quarter 10Health News:GlaxoSmithKline to Divest US Rights for Wellbutrin XL(R) to Biovail for $510 Million 2Health News:Banner Health, M. D. Anderson Announce Cancer Care Facility for Arizona 2Health News:Banner Health, M. D. Anderson Announce Cancer Care Facility for Arizona 3Health News:Manhattan Dentist Inducted Into The Sir Harold Acton Society 2Health News:Max Muscle Sports Nutrition Offers Support for Hydroxycut Recall 2Health News:Max Muscle Sports Nutrition Offers Support for Hydroxycut Recall 3Health News:Diabetes Discharge Planning is this the latest Topic in Focus at the Diabetes Best Practices Website 2
(Date:5/1/2015)... 2015 Braeburn Pharmaceuticals announced today ... focus beyond addiction and pain to include ... has acquired an implantable, six-month formulation of ... treatment of schizophrenia from Endo Pharmaceuticals. With ... to other potential applications of the implant ...
(Date:5/1/2015)... May 1, 2015 Pharmacyclics, Inc. (the "Company") ... the quarter ended March 31, 2015, as well as ... Inc., no conference call will be held. ... ended March 31, 2015 increased to $206 million from ... , Worldwide IMBRUVICA ® (ibrutinib) net product ...
(Date:5/1/2015)... May 1, 2015  Misonix, Inc. (NASDAQ: ... designs, manufactures and markets innovative therapeutic ultrasonic products ... cosmetic surgery, laparoscopic surgery and other surgical applications, ... for the third quarter fiscal year 2015 on ... a conference call that same day, Thursday, May ...
Breaking Medicine Technology:Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 2Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 3Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 4Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 5Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 6Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 7Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 8Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 9Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 10Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 11Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 12Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 13Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 14Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 15Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 16Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 17Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 18Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 19Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 20Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 21Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 22Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 23Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 24Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 25Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 26Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 27Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 28Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 29Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 30Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 31Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 32Pharmacyclics Reports First Quarter 2015 Financial Results and Provides Business Updates 33
... Oct. 16 Solos Endoscopy, Inc. (Pink Sheets: SNDY) ... received multiple purchase orders for its MammoView(TM) line ... Wheaton Franciscan Healthcare is one of the largest ... Endoscopy,s MammoView(TM) system employs advanced micro endoscopes and ...
... each state is responsible for its Women Infant Children program ... supplies. A state bid notification for breastpumps and supplies was ... needs further attention. The bid,s breastpump requirement was that the ... The state felt that it was acceptable for the pumps ...
Cached Medicine Technology:Solos Endoscopy, Inc. Receives Multiple Purchase Orders for its MammoView(TM) Product Line 2Do Women Have a Right to a Breastpump That Works? Asks Hygeia 2
Liquichek™ Homocysteine Control is a liquid control for monitoring homocysteine test procedures. This product can be used or methods such as HPLC and automated immunoassay procedures....
Bio-Rad's Liquichek™ D-dimer Control provides the laboratory with a liquid, trilevel, human plasma based control for the monitoring of D-dimer testing on most automated coagulation, chemistry a...
Lyphochek Diabetes Control is a human whole blood based product used to monitor hemoglobin fractions associated with diabetes, including Hemoglobins A1, A1C, F and Total Glycated Hemoglobin....
Lyphochek Hemoglobin A2 Control is a human whole blood based product designed to monitor the performance of automated and manual procedures for the measurement of hemoglobin variants, including Hemog...
Medicine Products: