Navigation Links
Team of researchers finds possible new genetic risk for Alzheimer's disease
Date:9/23/2010

Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease, the most common form of the disease. The gene, abbreviated as MTHFD1L, is on chromosome six, and was identified in a genome-wide association study. Details are published September 23 in the journal PLoS Genetics.

The collaborative team of researchers was led by Margaret A. Pericak-Vance, PhD, Director of the John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine; Joseph D. Buxbaum, PhD, Department of Psychiatry, Mount Sinai School of Medicine; and Jonathan L. Haines, PhD, Vanderbilt Center for Human Genetics Research, Vanderbilt University. The researchers were able to identify small differences in the genetic sequences of the MTHFD1L gene in people with and without Alzheimer's disease. The team found that individuals with the variation may be nearly twice as likely to develop Alzheimer's disease as people without the variation. The researchers observed the gene variation throughout the human genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 without the disease.

"Identifying this gene is important because the gene is known to be involved in influencing the body's levels of homocysteine, and high levels of homocysteine are a strong risk factor for late-onset Alzheimer disease," said Dr. Pericak-Vance. "In addition, variations of the MTHFD1L gene have been reported to possibly increase the risk of coronary artery disease. Since the function of blood vessels in the brain may affect Alzheimer's disease, this finding may help us understand how homocysteine levels and blood vessel function in the brain affect Alzheimer's disease."

"This finding gives us unique insight into possible interactions between genetic and environmental risk factors that contribute to AD," said Dr. Buxbaum. "We know of environmental and lifestyle factors that can impact homo
'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
2. European Researchers Find Genes Tied to Asthma
3. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
4. Queens University researchers locate impulse control center in brain
5. Researchers investigate differences in quality of care delivered by US resident and staff physicians
6. UNC researchers identify genetic patterns that may predict osteoarthritis
7. Mayo-led researchers discover genetic variants modifying breast cancer risk
8. Rutgers researchers discover how HIV resists AZT
9. Researchers at SUNY Downstate find drug combination may treat traumatic brain injury
10. Do the math, say UCLA researchers
11. MIT researchers discover an unexpected twist in cancer metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... ... may extend and improve the lives of patients, according to a newly published ... here to read the full article. , The authors of the new ...
(Date:8/29/2015)... ... ... ProDrop Particles includes over 40 particle backdrops designed for use in ... users can shrink and stretch in the Final Cut Pro X timeline. Choose from ... scale, speed, range, and flare attributes with intuitive controls found in the top-right inspector ...
(Date:8/29/2015)... Houston, TX (PRWEB) , ... August 29, 2015 ... ... settlement allows the company to freely market and sell Arterosil and Arterosil HP, ... Daniels Health Sciences, LLC (DHS) sued Vascular Health Sciences, LLC (VHS) in the ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... No Malaria Day at the Zoo to celebrate children helping children, a thank ... their congregations throughout West Ohio have contributed to the United Methodist initiative to ...
(Date:8/28/2015)... ... 28, 2015 , ... For Dallas, the time is nearing for the annual ... Tenet Health. , The American Heart Association hosts their well-known Heart Walk to raise ... together, a difference can be made. Walkers can participate in the cause and someone ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2
... The American Lung Association in Iowa is happy to report ... Family Smoking Prevention and Tobacco Control Act (HR 1256) today. ... applauds Senators Tom Harkin and Chuck Grassley for playing instrumental roles ... the Family Smoking Prevention and Tobacco Control Act. This important legislation ...
... June 11 The Campaign for Tobacco-Free Kids applauds ... today to approve historic legislation that gives the U.S. ... products, including the authority to crack down on tobacco ... the bipartisan bill 79 to 17. The House has ...
... Kids applauds U.S. Senators Judd Gregg and Jeanne Shaheen for ... Food and Drug Administration (FDA) authority to regulate tobacco products, ... sales to kids. The U.S. Senate approved the bipartisan ... legislation, and Congress is expected to quickly send a final ...
... The Campaign for Tobacco-Free Kids applauds U.S. Senator Sherrod Brown ... historic legislation that gives the U.S. Food and Drug Administration ... crack down on tobacco marketing and sales to kids. ... 17. The House has approved similar legislation, and Congress ...
... , WASHINGTON, June 11 The Campaign for ... for voting today to approve historic legislation that gives the ... products, including the authority to crack down on tobacco marketing ... bipartisan bill 79 to 17. The House has approved ...
... June 11 Oclaro, Inc. (Nasdaq: OCLR ... has entered the eye-safe wavelength market with laser diode ... micrometer (um). The new long-wavelength devices target eye-safe applications ... , Eye-safe standards are important in environments where there ...
Cached Medicine News:Health News:Senators Harkin and Grassley Vote to Protect America's Kids from Tobacco 2Health News:Senators Harkin and Grassley Vote to Protect America's Kids from Tobacco 3Health News:Senators Gregg and Shaheen Vote to Protect America's Kids From Tobacco 2Health News:Senator Brown Leads Fight to Protect America's Kids from Tobacco 2Health News:Senators Murkowski and Begich Vote to Protect America's Kids from Tobacco 2Health News:Oclaro Launches Eye-Safe High Power Laser Diodes at LASER 2009 2Health News:Oclaro Launches Eye-Safe High Power Laser Diodes at LASER 2009 3
(Date:8/28/2015)... N.J. , Aug. 28, 2015  IP Shakti, LLC, ... LLC. ... "Our new corporate identity signifies our transformation ... world,s first predictive analytics platform for patent claim validity." ... the launch of the proprietary AIA Shield™ platform, the Company ...
(Date:8/28/2015)... Denmark and ATLANTA , ... 2015 the US Food and Drug Administration (FDA) cleared the ... Disorder in adult patients who have failed to receive satisfactory ... is a non-invasive technique for stimulating neural tissue in the ... Depressive Disorder. The procedure has been proven safe and effective ...
(Date:8/28/2015)... August 28, 2015 The report "Eubiotics Market by ... Poultry, Ruminant, and Aquaculture), & by Region ( North ... Asia-Pacific , and Rest of the World) - Global ... market for Eubiotics was valued at USD 4.62 Billion in ... 2020, at a CAGR of 7.4% from 2015 to 2020. ...
Breaking Medicine Technology:IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 2Therapy System for Treating Major Depressive Disorder Receives FDA Clearance 3Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5
... BARCELONA, Spain , June 1 Clinicians at Institut Catala ... in Spain using RapidArc® radiotherapy from Varian Medical Systems (NYSE: ... the first patient in the country to receive the fast and efficient ... "The treatment went ...
... BEIJING , June 1 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... it has received,the confirmation from the China International Tendering Company that Sinovac,was ... supply the Company,s hepatitis A vaccine, Healive, to the,Beijing Expanded Program of ... ...
Cached Medicine Technology:Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 2Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 3Prostate Cancer Patient First in Spain to Receive Fast and Precise RapidArc(R) Radiotherapy Treatment from Varian 4Sinovac Selected by Beijing CDC to Supply Hepatitis A Vaccine Healive(R) 2Sinovac Selected by Beijing CDC to Supply Hepatitis A Vaccine Healive(R) 3
... a FAM-labeled probe that is designed to detect ... In addition, this ASR contains primers, a Texas ... sequence. This ASR requires an instrument that can ... as the Cepheid SmartCycler System. The Cepheid Analyte ...
... SpideRX Embolic Protection Device features the ability ... cross the lesion and a pre-loaded nitinol ... and recovery. Offering a fully rapid exchange ... use in the indicated applications:, Carotid Indication ...
Pefakit PiCT DxS Diluent for Determination of Total Heparin...
Controls for APC Resistance / Factor V Leiden Functional Assay...
Medicine Products: