Navigation Links
Team led by Scripps Scientists increases understanding of two types of blindness
Date:2/6/2009

Though based on mouse studies, the research bolsters the idea that humans suffering from these and other eye conditions may be able to help preserve function by adding antioxidants to their diet, and explains why this would work. The team also devised a new cell-based gene therapy technique that could eventually offer another option for arresting vision loss from these diseases.

The work, led by Scripps Research Professor Martin Friedlander, M.D., Ph.D., was reported in an advance, online edition of the Journal of Clinical Investigation on February 2, 2009. The research is also likely to apply to a range of other neurodegenerative conditions, including vision loss from Huntington's and Alzheimer's diseases and inherited retinal degenerations, such as retinitis pigmentosa.

Many forms of blinding degenerative eye conditions are tied to the abnormal proliferation of new blood vessels in the eyes, or neovascularization. Treatment of these conditions has generally focused on blocking continued neovascularization, but this typically only slows disease progression because new growth eventually wins out, leading to continued damage and vision loss.

For many of these conditions, vision loss has been definitively attributed to the blinding effect of fluid leakage and hemorrhage from newly grown blood vessels. But the cause of vision loss in certain diseases such as MacTel has been more elusive.

To better understand these eye diseases, and to develop new and better treatments, the research team examined a mouse model of these human diseases. The particular "knockout" mouse the team focused on has been used by other researchers for studying fat metabolism. The mouse model, however, also has a genetic alteration that leads to increased blood vessel growth in the eyesa fact that Friedlander and colleagues had pointed out in a previous publication. In this model, neovascularization occurs in the back of the eyes in an area of the
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
9. Scripps research team wins $4M grant to study effects of chronic marijuana use
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scripps Memorial Hospital Nurses Throw Out CNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Steven Reinberg HealthDay ... The number of U.S. teens using sunscreen dropped nearly 12 ... During that same time period, the number of teens using ... to use sunscreen increase the risk of skin cancers, including ... decrease in the overall percentage of teens who reported wearing ...
(Date:8/21/2014)... St. Louis, MO (PRWEB) August 21, 2014 ... work in family and product liability law, announces the ... The website provides comprehensive information on morcellator surgery ... the April 2014 FDA morcellator cancer warning and the ... news release* accompanying the April 17, 2014 FDA warning ...
(Date:8/21/2014)... announces the immediate release of Care of the ... CHEST Consensus Statement today in the Online First ... the global health-care community cares for patients with ... guide ethical decision-making, coordination of care, resource conservation, ... by over 100 clinicians and experts representing a ...
(Date:8/21/2014)... international scientific collaboration led by Baylor College of Medicine ... to a rare form of kidney cancer, providing new ... types as well. , The collaboration, a project of ... initiative , completed the sequence of chromophobe renal cell ... Cancer Cell . , "The Cancer Genome ...
(Date:8/21/2014)... have developed a genetically engineered line of mice that ... on epilepsy, Alzheimer,s and other diseases. , The ... of fluorescence in response to different calcium levels. This ... and microglia, to be studied in a new way. ... how the brain works," said Petr Tvrdik, Ph.D., ...
Breaking Medicine News(10 mins):Health News:Fewer U.S. Teens Using Sunscreen, Study Finds 2Health News:The Onder Law Firm Launches National Morcellator Cancer Lawsuit Center Website for Morcellator Surgery Lawsuits at MorcellatorCancerLawsuitCenter.com 2Health News:The Onder Law Firm Launches National Morcellator Cancer Lawsuit Center Website for Morcellator Surgery Lawsuits at MorcellatorCancerLawsuitCenter.com 3Health News:CHEST releases new expert guidance in care of the critically ill and injured 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 2Health News:Sequence of rare kidney cancer reveals unique alterations involving telomerase 3Health News:Mouse model for epilepsy, Alzheimer's gives window into the working brain 2
... found that radiotherapy given in large dosage but in small ... UK and US said that 13 larger doses were found ... to the conventional regime of 25 small doses. The findings ... funded by the Cancer Research UK. They analysed 1,410 women ...
... driving skills of motorist has resulted in over 4,000 people ... the last three years// , said a senior Delhi Police ... around 1,500 sq km and it is difficult to control ... not up to the mark," Qamar Ahmed, joint commissioner, traffic, ...
... here who have been protesting the central government decision ... have sought// President A.P.J. Abdul Kalam's permission for self-immolation. ... seeking his "permission to immolate themselves", informed Ashutosh Dixit, ... of the junior doctors sitting on a relay hunger ...
... of alcohol may reduce the risk of heart disease than ... that it is applicable only for men and women are ... drinking patterns and heart health among men and women, but ... caution and should not be used to justify potentially harmful ...
... statistics regarding the use of tobacco amongst teenagers, which has ... tobacco and its products. , ,These figures were made ... World No Tobacco Day; on May 31st. This years theme ... or disguise,'' conveying cigarette smoking in any form is extremely ...
... major factor causing health concerns among both the pregnant woman ... that pregnant working// mothers who undergo a lot of stress ... these children were five ounces lighter than the average birth ... case pregnant smokers. These pregnant mothers put themselves through 32 ...
Cached Medicine News:Health News:Road Traffic Accidents Kill 4,000 people in Delhi 2Health News:Daily Intake Of Alcohol Reduces Heart Disease In Men Than Women 2
(Date:8/21/2014)... , Aug. 21, 2014 /CNW/ - Bedrocan Cannabis Corp., ... independent members to its Board of Directors, enhancing ... of the company, a leading licensed producer of ... Internationally, Bedrocan has 13 years, experience in producing ... seven countries, including Canada. As ...
(Date:8/21/2014)... CYBX ) today announced results for the quarter ended ... Operating results for the first quarter of fiscal ... other achievements, include: , Worldwide net product sales of ... net sales of $13.2 million, an increase of 14.5% on ... reached a new high of $58.8 million, an increase of ...
(Date:8/21/2014)... MENLO PARK, Calif. , Aug. 21, 2014 /PRNewswire/ ... company in the emerging field of regenerative medicine, announced ... ("Nat") Ricciardi to the Company,s newly expanded Board of ... now comprises eight directors, three of whom are independent. ... years of experience working with emerging growth companies. He ...
Breaking Medicine Technology:Senior Life Sciences Executives Join Bedrocan as Independent Directors 2Senior Life Sciences Executives Join Bedrocan as Independent Directors 3Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4
... 28, 2011 Tengion, Inc. (Nasdaq: TNGN ) ... to its Board of Directors. Mr. Flora brings to Tengion ... wound healing and surgical device businesses.  He most recently served ... Tengion also announced today that Gary Kurtzman, ...
... SOUTH SAN FRANCISCO, Calif., Sept. 28, 2011 Onyx ... that it has completed the New Drug Application (NDA) ... under the accelerated approval process for carfilzomib, a next ... with relapsed and refractory multiple myeloma. In addition, Onyx ...
Cached Medicine Technology:Tengion Appoints Scott Flora to Board of Directors 2Tengion Appoints Scott Flora to Board of Directors 3Tengion Appoints Scott Flora to Board of Directors 4Onyx Pharmaceuticals Submits New Drug Application for Carfilzomib in Relapsed and Refractory Multiple Myeloma 2Onyx Pharmaceuticals Submits New Drug Application for Carfilzomib in Relapsed and Refractory Multiple Myeloma 3Onyx Pharmaceuticals Submits New Drug Application for Carfilzomib in Relapsed and Refractory Multiple Myeloma 4
...
...
Bimanual I&A Cannulas. Curved 45 with a .51mm open-end irrigation port. Facilitates removal of cortical debris between 10-2 o'clock. .80mm x 17.0mm...
...
Medicine Products: